Results 51 to 60 of about 2,522,601 (297)

Genetic variability of the prion protein gene (PRNP) in wild ruminants from Italy and Scotland [PDF]

, 2009
The genetics of the prion protein gene (PRNP) play a crucial role in determining the relative susceptibility to transmissible spongiform encephalopathies (TSEs) in several mammalian species.
Acutis, Pier Luigi, Pier Luigi Acutis, Ezio Ferroglio, Simone Peletto, Hugh W. Reid, Perucchini, Matteo, Serena Robetto, Acin, Cristina, Bozzetta, Elena, Reid, Hugh W., Dalgleish, Mark P., Orusa, Riccardo, Elena Bozzetta, Ferroglio, Ezio, Sacchi, Paola, Paula Stewart, Daniela Meloni, Wilfred Goldmann, Meloni, Daniela, Gennero, Silvia, Riccardo Orusa, Roberto Rasero, Rasero, Roberto, Cristina Acín, Matteo Perucchini, Mark P. Dalgleish, Goldmann, Wilfred, Stewart, Paula, Maria Caramelli, Silvia Gennero, Caramelli, Maria, Robetto, Serena, Peletto, Simone, Paola Sacchi, Ferroglio, E., Peletto, S., Gennero, S., Sacchi, P., Perucchini, M., Acin, C., Robetto, S., Caramelli, M., Dagleish, M.P., Stewart, P., Rasero, R., Acutis, P.L., Bozzetta, E., Goldmann, W., Meloni, D., Reid, H.W., Orusa, R.   +50 more
core   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Genetic polymorphisms of αS1-, αS2- and k-casein in Maltese goat breed

Italian Journal of Animal Science, 2011
The casein genes are organized as a tight cluster including αS1- (CSN1S1), β- (CSN2), αS2- (CSN1S2) and k-casein (CSN3). Investigation at casein haplotype level is therefore necessary to detect effects which could be used for the genetic
A. Caroli, G. Erhardt, C. Dario, G. Ceriotti, S. Chessa   +4 more
doaj   +1 more source

Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations

iScience, 2022
Summary: Neuronal oscillations, their inter-areal synchronization, and scale-free dynamics constitute fundamental mechanisms for cognition by regulating communication in neuronal networks.
Jaana Simola, Felix Siebenhühner, Vladislav Myrov, Katri Kantojärvi, Tiina Paunio, J. Matias Palva, Elvira Brattico, Satu Palva   +7 more
doaj   +1 more source

Polymorphisms in bovine immune genes and their associations with somatic cell count and milk production in dairy cattle [PDF]

, 2010
peer-reviewedBackground: Mastitis, an inflammation of the mammary gland, is a major source of economic loss on dairy farms. The aim of this study was to quantify the associations between two previously identified polymorphisms in the bovine toll-like ...
Magee, David A, Daly Mairead, Christine Beecher, McCarthy Tommie V, Tommie V McCarthy, Linda Giblin, David A Magee, Giblin Linda, Berry Donagh P, Magee David A, Donagh P Berry, Beecher Christine, Stuart Childs, McCarthy, Tommie V, Giblin, Linda, Mairead Daly, Beecher, Christine, Daly, Mairead, Childs, Stuart, Childs Stuart, Berry, Donagh   +20 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

ASPIRIN RESISTANCE CANDIDATE GENES AND THEIR ASSOCIATION WITH THE RISK OF CARDIOVASCULAR EVENTS

Кардиоваскулярная терапия и профилактика, 2013
The review presents the current literature evidence on the most likely genetic polymorphisms of aspirin resistance, such as polymorphisms of cyclooxygenase, glycoproteins GP Ib/IIIa, GP Ibα, GP VI, and adenosine diphosphate receptors P2Y1 and P2Y12.
Yu. I. Grinshtein, A. A. Kosinova, I. Yu. Grinshtein   +2 more
doaj   +1 more source

The incidence of liver injury in Uyghur patients treated for TB in Xinjiang Uyghur autonomous region, China, and its association with hepatic enzyme polymorphisms nat2, cyp2e1, gstm1 and gstt1. [PDF]

, 2014
BACKGROUND AND OBJECTIVE: Of three first-line anti-tuberculosis (anti-TB) drugs, isoniazid is most commonly associated with hepatotoxicity. Differences in INH-induced toxicity have been attributed to genetic variability at several loci, NAT2, CYP2E1 ...
Ma, Jinfeng, Xuemei Yao, Mingqin Cao, Merle Corinne, Xia Zhu, Liu Wei, Weidong Wu, Yongguang Li, Jiayi Gu, Ma Jinfeng, Qian Wang, Milligan Paul, Zhu, Xia, Ying Mao, Liu, Wei, Ma Long, Jinfeng Ma, Xiang, Yang, Cao, Mingqin, Ma, Long, Merle, Corinne, Long Ma, Yang Lei, Xiang Yang, Yao Xuemei, Wubuli, Atikaimu, Wu, Weidong, Xin Xiumei, Li, Yongguang, Yang Xiang, Paul Milligan, Xiumei Xin, Lei Yang, Corinne Merle, Zhu Xia, Li Yongguang, Mao Ying, Milligan, Paul, Mao, Ying, Gu, Jiayi, Atikaimu Wubuli, Gu Jiayi, Yao, Xuemei, Wu Weidong, Wang Qian, Yang, Lei, Xin, Xiumei, Wang, Qian, Cao Mingqin, Wubuli Atikaimu, Wei Liu   +50 more
core   +1 more source

SORL1 polymorphisms in Mexican patients with Alzheimer\u27s disease [PDF]

, 2022
The present study evaluated the risk effect of 12 Single Nucleotide Polymorphisms in the SORL1 gene in the Mexican population using Late-Onset Alzheimer\u27s Disease (LOAD) and control subjects.
Becerril-Pérez, Fernando, Sánchez-Torres, Carmen, Campos-Peña, Victoria, Rosas-Carrasco, Óscar, Delgado-Namorado, Yair, Nancy Lucero Martínez Rodríguez, Carmen Sánchez-Torres, Toral-Rios, Danira, Mena-Barranco, Francisco, Rosa Carvajal-García, Rodríguez, Nancy Lucero Martínez, Elizabeth Ruiz-Sánchez, Ruiz-Sánchez, Elizabeth, Yair Delgado-Namorado, Fernando Becerril-Pérez, Danira Toral-Rios, Marlene Maury-Rosillo, Silva-Adaya, Daniela, Gerardo Ramos-Palacios, Daniela Silva-Adaya, Carvajal-García, Rosa, Francisco Mena-Barranco, Victoria Campos-Peña, Ramos-Palacios, Gerardo, Óscar Rosas-Carrasco, Maury-Rosillo, Marlene   +25 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source