War without weapons:constitution of healthy and pathological phenotypes associated with polymorphisms in genes involved in the maintenance of genome integrity [PDF]
, 2012 Capacity to repair DNA damage may vary significantly between individuals coming out as healthy on routine physical and laboratory examinations. This variance does not generally cause distress or disease unless in case that specific triggers are present ...
Khalil, Hilal S. +1 more
core +3 more sources
Association between insertion/deletion polymorphism of the ace gene with risk of hypertension
Genetics & Applications, 2023 This study conducted an initial investigation into the association between ACE gene insertion/deletion (I/D) polymorphisms (rs1799752) and hypertension in the Republic of Srpska, Bosnia and Herzegovina.
Jovan Kulić +6 more
doaj +1 more source
Anti-Müllerian Hormone Gene Polymorphisms: Global Perspectives and Arab Population Insights
Dubai Medical JournalIntroduction: Anti-Müllerian Hormone (AMH) gene polymorphisms significantly impact ovarian function, follicular development, and fertility outcomes.
Huda Omran
doaj +1 more source
Polymorphism of human haptoglobin and its clinical importance
Genetics and Molecular Biology, 2008 Haptoglobin (Hp) is a plasma glycoprotein, the main biological function of which is to bind free hemoglobin (Hb) and prevent the loss of iron and subsequent kidney damage following intravascular hemolysis.
Vânia Peretti de Albuquerque Wobeto +2 more
doaj +1 more source
Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts. [PDF]
, 2018 OBJECTIVES: To develop and validate a genetic tool to predict age of onset of aggressive prostate cancer (PCa) and to guide decisions of who to screen and at what age.
core +2 more sources
Gene polymorphisms as markers of disease susceptibility [PDF]
Journal of Medical Biochemistry, 2010 The most widespread diseases of modern man have a polygenic basis, including genetic predisposition and factors in the external environment. Such is the case with cardiovascular disease, malignancy, diabetes and so on.
Novaković Ivana +3 more
doaj
The quantitative genetics of phenotypic robustness. [PDF]
PLoS ONE, 2010 Phenotypic robustness, or canalization, has been extensively investigated both experimentally and theoretically. However, it remains unknown to what extent robustness varies between individuals, and whether factors buffering environmental variation also ...
Hunter B Fraser, Eric E Schadt
doaj +1 more source
Genetic polymorphism of cytochrome p450 (2C19) enzyme in Iranian Turkman ethnic group [PDF]
, 2013 Objective: Different findings indicate that CYP2C plays a clinical role in determining interindividual and interethnic differences in drug effectiveness. The ethnic differences in the frequency of CYP2C19 mutant alleles continue to be a significant study
Ataby, O.A. +4 more
core +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Treatment‐associated hepatotoxicity (TAH) is a common complication of pediatric acute lymphoblastic leukemia (ALL) treatment, but genetic risk factors remain poorly understood. We evaluated the SOD2 rs4880 variant in 544 children with ALL at Texas Children's Hospital. After adjusting for demographic and clinical covariates, the rs4880 C allele
Emily J. Mason +14 more
wiley +1 more source
Emotional dimension associated with the migratory experience of adult refugees and asylum seekers
Scientific ReportsThis study explores the impact of the migratory process on the mental health of refugees and asylum seekers arriving in Spain. It examines the feelings and emotions associated with emigration, alongside its underlying causes. A mixed-methods approach was
María José Cáceres-Titos +2 more
doaj +1 more source