Results 21 to 30 of about 2,522,601 (297)

Genetic polymorphisms in lung disease: bandwagon or breakthrough?

Respiratory Research, 2002
The study of genetic polymorphisms has touched every aspect of pulmonary and critical care medicine. We review recent progress made using genetic polymorphisms to define pathophysiology, to identify persons at risk for pulmonary disease and to predict ...
Rybicki Benjamin, Maliarik Mary, Iannuzzi Michael C   +2 more
doaj   +1 more source

Genetic modifiers of chromatin acetylation antagonize the reprogramming of epi-polymorphisms.

PLoS Genetics, 2012
Natural populations are known to differ not only in DNA but also in their chromatin-associated epigenetic marks. When such inter-individual epigenomic differences (or "epi-polymorphisms") are observed, their stability is usually not known: they may or ...
Anne-Laure Abraham, Muniyandi Nagarajan, Jean-Baptiste Veyrieras, Hélène Bottin, Lars M Steinmetz, Gaël Yvert   +5 more
doaj   +1 more source

Genetic polymorphisms in sepsis

Pediatric Critical Care Medicine, 2005
Wide variability exists in the susceptibility to and outcome from sepsis even within similar intensive care unit populations. Some of this variability in the host may be due to genetic variation in genes coding for components of the innate immune response.To review the evidence for a genetic influence on the susceptibility to and outcome from sepsis ...
Mary K, Dahmer, Adrienne, Randolph, Sally, Vitali, Michael W, Quasney   +3 more
openaire   +3 more sources

Candidate polymorphisms and severe malaria in a Malian population. [PDF]

, 2012
Malaria is a major health burden in sub-Saharan African countries, including Mali. The disease is complex, with multiple genetic determinants influencing the observed variation in response to infection, progression, and severity.
Belco Poudiougou, Toure, Ousmane, Sall, Abdourahmane H, Kirk A Rockett, Ogobara Doumbo, Sissoko Sibiri, Diarra Elisabeth, Amadou Niangaly, Konate Salimata, Barry, Abdoulaye, Taane G Clark, Taane G. Clark (106263), Sibiri Sissoko, Poudiougou Belco, Sall Abdourahmane H., Thera, Mahamadou A, Ousmane Toure (22538), Collaboration with The MalariaGEN Consortium, Mahamadou A Thera, Abdourahmane H Sall, Nuno Sepulveda, Poudiougou, Belco, Clark, Taane G, Sibiri Sissoko (138104), Thera Mahamadou A., Elisabeth Diarra (138119), Salimata Konate (138100), Campino Susana, Doumbo Ogobara, Diarra, Elisabeth, Nuno Sepulveda (124822), Ousmane Toure, Susana Campino, Kirk A. Rockett (138127), Rockett, Kirk A, Abdourahmane H. Sall (138114), Toure Ousmane, Amadou Niangaly (83858), Ogobara Doumbo (35290), Barry Abdoulaye, Campino, Susana, Susana Campino (56411), Rockett Kirk A., Abdoulaye Barry (138109), Clark Taane G., Sepulveda, Nuno, Elisabeth Diarra, Konate, Salimata, Abdoulaye Barry, Belco Poudiougou (22535), Mahamadou A. Thera (35284), Sepulveda Nuno, Niangaly, Amadou, Salimata Konate, Niangaly Amadou, Sissoko, Sibiri, Doumbo, Ogobara   +56 more
core   +2 more sources

Genetic polymorphism and the link to stress-induced metabolic dysfunction

Babcock University Medical Journal, 2023
Background: The impact of stress on health is well-established and it continues to influence modern life. While some individuals may manage stress well, others may experience detrimental impacts on their physical and emotional health. As stress has been
Adekunle Mofolorunso, Funmileyi Awobajo, Patrick Okwute   +2 more
doaj   +1 more source

Effects of interacting networks of cardiovascular risk genes on the risk of type 2 diabetes mellitus (the CODAM study) [PDF]

, 2008
Background: Genetic dissection of complex diseases requires innovative approaches for identification of disease-predisposing genes. A well-known example of a human complex disease with a strong genetic component is Type 2 Diabetes Mellitus (T2DM ...
Paul MH Schiffers, Carla JH van der Kallen, Zhang, Jian, Kallen Carla JH, Schiffers, Paul M. H., van der Kallen, Carla J. H, Zhang Jian, Schiffers Paul MH, de Bruin Tjerk WA, van Greevenbroek Marleen MJ, Feskens Edith JM, Edith JM Feskens, Tjerk WA de Bruin, Jian Zhang, Marleen MJ van Greevenbroek, de Bruin, Tjerk W. A., Feskens, Edith J. M., van Greevenbroek, Marleen M.J., Greevenboek, M.M., van, Kallen, C.J., Bruin, T.W., Zhang, J., Feskens, E.J.M., Schiffers, P.M.   +23 more
core   +2 more sources

Single nucleotide polymorphisms in asthma candidate genes TBXA2R, ADAM33 FCER1B and ORMDL3 in Pakistani asthmatics a case control study

Asthma Research and Practice, 2018
Background Genetic variations in different loci and genes are important in asthma pathogenesis. There is much importance of various immunological pathways in the IgE secretion regulation.
Nusrat Saba, Osman Yusuf, Sadia Rehman, Saeeda Munir, Amna Noor, Muhammad Saqlain, Atika Mansoor, Ghazala Kaukab Raja   +7 more
doaj   +1 more source

Genetic polymorphisms in Afghanistan

Annals of Human Biology, 1977
The gene frequencies in samples of two language groups from Afghanistan, comprising 104 Pushtu and 179 Dari subjects living in Kabul, have been examined for 24 loci. Some systems suggest greater affinity to the west (e.g. the MS gene combination, the esterase D2 allele), some to the east (e.g.
S S, Papiha, D F, Roberts, A G, Rahimi
openaire   +2 more sources

Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release : an observational study in three cohorts [PDF]

, 2010
Introduction: It has been proposed that individual genetic variation contributes to the course of severe infections and sepsis. Recent studies of single nucleotide polymorphisms (SNPs) within the endotoxin receptor and its signaling system showed an ...
Koch, Alexander, David A Schwartz, van der Meer, Jos W. M., Latz, E., Eicke Latz, Djin-Ye Oh, Schumann, Ralf R, Schumann, R.R., Chryssanthi Skalioti, van der Meer, Jos WM, Jos WM van der Meer, Kumpf, Oliver, Skalioti, C., Eva Lorenz, van der Meer, J.W., Schwartz, David A, Schlag, Peter M., Netea, M.G., Giamarellos-Bourboulis, Evangelos, Bart-Jan Kullberg, Kai Zacharowski, Mouktaroudi, Maria, Mouktaroudi, M., Latz, Eicke, Lorenz, Eva, Netea, Mihai G, Kumpf, O., Schlag, P.M., Kullberg, B.J., Schlag, Peter M, Peter M Schlag, Hamann, L., Lorenz, E., Lutz Hamann, Ferwerda, B., Maria Mouktaroudi, Christina Routsi, Alexander Koch, Zacharowski, Kai, Oliver Kumpf, Schumann, Ralf R., Routsi, C., Evangelos J Giamarellos-Bourboulis, Bart Ferwerda, Mihai G Netea, Routsi, Christina, Koch, A., Schwartz, David A., Skalioti, Chryssanthi, Ralf R Schumann, Giamarellos-Bourboulis, E.J., Meer, J.W.M. van der, Kullberg, Bart-Jan, Hamann, Lutz, Netea, Mihai G., Giamarellos-Bourboulis, Evangelos J., Oh, D.Y., Schwartz, D.A., Oh, Djin-Ye, Zacharowski, K., Ferwerda, Bart, Giamarellos-Bourboulis, Evangelos J   +61 more
core   +1 more source

Interleukin-1 gene polymorphisms and their relation with NFkB expression and histopathological features in psoriasis

Indian Journal of Dermatology, 2015
Background: Psoriasis is a chronic inflammatory disease driven by exaggerated production of pro-inflammatory cytokines and interleukins. Various genetic polymorphisms including IL-1 are implicated in pathogenesis of psoriasis. The exact role of IL-1 gene
Nikhil Moorchung, Biju Vasudevan, Manas Chatterjee, N S Mani, R S Grewal   +4 more
doaj   +1 more source