Results 41 to 50 of about 2,522,601 (297)

Novel Polymorphisms and Genetic Characteristics of the Prion Protein Gene in Pheasants

Frontiers in Veterinary Science, 2022
Transmissible spongiform encephalopathies (TSEs) also known as prion diseases, are fatal neurodegenerative diseases. Prion diseases are caused by abnormal prion protein (PrPSc) derived from normal prion protein (PrPC), which is encoded by the prion ...
Kyung Han Kim, Kyung Han Kim, Yong-Chan Kim, Yong-Chan Kim, Byung-Hoon Jeong, Byung-Hoon Jeong   +5 more
doaj   +1 more source

The quantitative genetics of phenotypic robustness. [PDF]

PLoS ONE, 2010
Phenotypic robustness, or canalization, has been extensively investigated both experimentally and theoretically. However, it remains unknown to what extent robustness varies between individuals, and whether factors buffering environmental variation also ...
Hunter B Fraser, Eric E Schadt
doaj   +1 more source

Bladder Cancer and Genetic Polymorphisms: A Review [PDF]

, 2015
The aetiology of bladder cancer (BC) is still not fully understood. Genetic factors and many different pathways could be involved in the formation and progression of the BC.
Yavuz Onur Danacıoglu, Turhan Çaşkurlu, Bulent Erol, Ismail Ulus   +3 more
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Emotional dimension associated with the migratory experience of adult refugees and asylum seekers

Scientific Reports
This study explores the impact of the migratory process on the mental health of refugees and asylum seekers arriving in Spain. It examines the feelings and emotions associated with emigration, alongside its underlying causes. A mixed-methods approach was
María José Cáceres-Titos, Ana María Fernández-Araque, E. Begoña García-Navarro   +2 more
doaj   +1 more source

Genetic polymorphisms as determinants of pesticide toxicity: Recent advances

Toxicology Reports, 2019
Occupational and environmental exposure to pesticides may induce harmful effects on human health by promoting the development of a wide range of disorders.
Michele Teodoro, Giusi Briguglio, Concettina Fenga, Chiara Costa   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Association of IFNL3 rs12979860 and rs8099917 with biochemical predictors of interferon responsiveness in chronic hepatitis C virus infection [PDF]

, 2013
Background & Aims: Genetic variations near the interferon lambda 3 gene (IFNL3, IL28B) are the most powerful predictors for sustained virologic response (SVR) in patients with chronic hepatitis C virus (HCV) infection, compared to other biochemical or ...
Simone Susser (48294), Annika Brodzinski, Thomas Berg (186372), Migaud, Pascal, Jacob George (205614), Brodzinski, Annika, Tobias Müller, Susser, Simone, Stephan Böhm (334611), Sarrazin, Christoph, Christoph Sarrazin (48298), Pascal Migaud, Schott, Eckart, Bömmel, Florian van, Heiko Witt, Florian van Bömmel, Janett Fischer, Christoph Sarrazin, Stewart, Graeme, Graeme Stewart, Witt, Heiko, Thomas Berg, Simone Susser, Balazs Fülöp, Fülöp, Balazs, Stephan Böhm, Annika Brodzinski (477753), Balazs Fülöp (477754), Müller, Tobias, Fischer, Janett, Böhm, Stephan, Berg, Thomas, Tobias Müller (163591), Janett Fischer (477751), Eckart Schott (320945), Graeme Stewart (208243), Jacob George, Heiko Witt (161481), Pascal Migaud (477752), George, Jacob, Eckart Schott, Florian van Bömmel (477755), Witt Heiko, Fischer, J;Bohm, S;Müller, T;Witt, H;Sarrazin, C;Susser, S;Migaud, P;Schott, E;Stewart, G;Brodzinski, A;Fülöp, B;Van Bömmel, F;George, J;Berg, T, Böhm Stephan, Susser Simone, Müller Tobias, Fülöp Balazs, Stewart Graeme, Fischer Janett, George Jacob, Brodzinski Annika, Migaud Pascal, Berg Thomas, Sarrazin Christoph, Schott Eckart, van Bömmel Florian   +56 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Pharmacogenetics of Efavirenz response in Bantu-speaking South African HIV/AIDS patients [PDF]

, 2011
Includes abstract.Includes bibliographical references (leaves 82-96).Efavirenz (EFV) is used in first-line antiretroviral (ARV) therapy of HIV-infected patients, and is principally metabolised by CYP1A2, CYP2A6, CYP2B6, CYP3A4/5 and the drug transporter ...
Swart, Marelize
core   +1 more source