Results 91 to 100 of about 191,359 (264)

Genetic predisposition to coronavirus-induced retinal disease.

Investigative ophthalmology & visual science, 1996
Retinal inflammatory and degenerative processes in humans and animals frequently are associated with genetic factors. The murine coronavirus, mouse hepatitis virus (MHV), JHM strain, induces a biphasic retinal disease in adult BALB/c mice. The genetic constitution of the host and the virus serotype can be critical factors in determining the outcome of ...
Y, Wang, M, Burnier, B, Detrick, J J, Hooks   +3 more
openaire   +1 more source

Time‐Resolved SAXS Reveals Distinct Millisecond Metal‐Induced Conformational Dynamics of Monomeric α‐Synuclein

Advanced Science, EarlyView.
Time‐resolved SAXS reveals how physiologically relevant metal ions shape the earliest conformational responses of monomeric α‐synuclein. Fe3+ induces rapid compaction, Cu2+ generates heterogeneous and partially folded ensembles, while Mn2+ and Zn2+ cause only modest changes.
Rebecca Sternke‐Hoffmann, Miriam Dos Santos Pinto, Xue Wang, Jinghui Luo   +3 more
wiley   +1 more source

Serum cystatin C as a biomarker for diabetic retinopathy and its role in diabetic retinopathy-diabetic kidney disease comorbidity

Journal of Translational Medicine
Background To investigate whether serum cystatin C (CysC) can serve as a biomarker for diabetic retinopathy (DR), and explore the comorbidity between DR and diabetic kidney disease (DKD).
Xiaosi Chen, Weichen Yuan, Yiyun Zeng, Hanyu Wu, Linghui Pi, Yang Yang, Xinming Gu, Xinyuan Zhang   +7 more
doaj   +1 more source

Deciphering and Targeting the Schwannoma‐Neuron‐Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain

Advanced Science, EarlyView.
We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin, Limeng Wu, Yanling Zhang, Yao Sun, Grace Y. Lee, Simeng Lu, Xing Gao, John W. Chen, Sonu Subudhi, William Ho, Chao Zhu, Jun Ren, Gino B. Ferraro, Alona Muzikansky, Anat Stemmer‐Rachamimov, Jianren Mao, Scott R. Plotkin, Lei Xu   +17 more
wiley   +1 more source

SR‐B1‐Mediated Transplacental Transfer of Hydrophobic Toxicants Disrupts Fetal Development During Barriergenesis

Advanced Science, EarlyView.
This study maps the spatiotemporal distribution of hydrophobic toxicants and endogenous metabolites in the developing placenta and fetus. By integrating mass spectrometry imaging with snRNA‐seq, we identify SR‐B1 as a key transporter driving early‐gestation xenobiotic transfer and reveal a critical exposure window associated with persistent fetal ...
Yixuan Huang, Hailin Shang, Ling Jiao, Ce Chen, Zehua Liu, Yi Yang, Qiannan Zhang, Song Tang, Xudong Jia, Hui Yang, Yi Wan   +10 more
wiley   +1 more source

Association of Human Leukocyte Antigen Alleles with COVID-19 Severity and Mortality in a Spanish Population

Medicina
Background and Objectives: The aim of the following cross-sectional study is to determine the association between human leukocyte antigen (HLA) alleles and outcomes in patients presenting to the emergency department (ED) with SARS-CoV-2 infection ...
Ester Lobato-Martinez, Javier Muriel-Serrano, Elena García-Payá, Pilar Gonzalez-de-la-Aleja, Raquel Garcia-Sevila, Mercedes Navarro-de-Miguel, Francisco Marco-de-la-Calle, Jose-Manuel Ramos-Rincon, Rosario Sanchez-Martinez   +8 more
doaj   +1 more source

Genetic Susceptibility to Hidradenitis Suppurativa and Predisposition to Cardiometabolic Disease

JAMA Dermatology
ImportanceHidradenitis suppurativa (HS) is associated with an increased prevalence of cardiovascular diseases compared with the general population. Any association between polygenic risk for HS, risk of incident cardiometabolic outcomes, and the plasma proteome is unclear.ObjectiveTo investigate the genetic correlation between HS and cardiometabolic ...
Nielsen, Valdemar Wendelboe, Vad, Oliver Bundgaard, Holgersen, Nikolaj, Paludan-Müller, Christian, Monfort, Laia Meseguer, Beyer, Astrid Filt, Jemec, Gregor Borut Ernst, Kjærsgaard Andersen, Rune, Egeberg, Alexander, Thyssen, Jacob P., Svendsen, Jesper Hastrup, Rosenø, Nana Aviaaja Lippert, Hansen, Peter Riis, Thomsen, Simon Francis, Salling Olesen, Morten   +14 more
openaire   +3 more sources

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

Promotion of DFU Wound Healing via BRG1–COL16A1 Axis in Fibroblasts

Advanced Science, EarlyView.
In normal wound healing, transcription factor BRG1 is upregulated and binds the COL16A1 promoter to enhance its expression, promoting fibroblast proliferation, migration, contraction, extracellular matrix deposition, and granulation tissue formation, thus accelerating wound closure.
Penghui Wang, Jiaming Sun, Ying Wang, Bichen Ren, Yuxin Liu, Yunhan Liu, Liang Chen, Lu Yu, Tao Dai, Li Yu, Zhihui Dong   +10 more
wiley   +1 more source

Periodontitis Induces B Cell‐Macrophage Crosstalk to Exacerbate Glucose Dysregulation in Obesity

Advanced Science, EarlyView.
In obesity, periodontitis exacerbates hyperglycemia and exhibits a liver‐centric preference for glucose regulation. This occurs through a periodontitis‐driven circuit between pathogenic B cells and hepatic macrophages. Their reciprocal expansion, orchestrated by the NLRP3/IL‐18 signaling pathway, amplifies metabolic inflammation and disrupts glucose ...
Wen‐Zhen Lin, Lu‐Jun Zhou, Hui‐Lin Ye, Ting Liu, Bo‐Yan Chen, Xue‐Bing Bai, Jun Zhang, Lan Bai, Lin‐Juan Du, Yuan Liu, Yong‐Li Wang, Hong Zhu, Yu‐Lin Li, Shuo Xu, Xiao‐Qian Meng, Guo‐Cai Tian, Yan Liu, Wu‐Chang Zhang, Ya‐Qin Zhu, Sheng‐Zhong Duan   +19 more
wiley   +1 more source