Sleep characteristics modify the association between genetic predisposition to obesity and anthropometric measurements in 119,679 UK Biobank participants [PDF]
, 2017 Background - Obesity is a multifactorial condition influenced by genetics, lifestyle and environment. Objective - To investigate whether the association between a validated genetic profile risk score for obesity (GPRS-obesity) with body mass index (BMI)
Bailey, Mark E.S. +10 more
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The Genetic Predisposition and the Interplay of Host Genetics and Gut Microbiome in Crohn Disease [PDF]
Clinics in Laboratory Medicine, 2014 Extensive genetic studies have identified more than 140 loci predisposing to Crohn disease (CD). Several major CD susceptibility genes have been shown to impair biological function with regard to immune response to recognizing and clearance of bacterial infection.
openaire +2 more sources
Genetics and Epigenetics of Arrhythmia and Heart Failure
Frontiers in Genetics, 2013 Heart failure (HF) is the end stage of several pathological cardiac conditions including myocardial infarction, cardiac hypertrophy and hypertension. Various molecular and cellular mechanisms are involved in the development of HF. At the molecular level,
Burcu eDuygu +2 more
doaj +1 more source
Rare germline variants in DNA repair genes and the angiogenesis pathway predispose prostate cancer patients to develop metastatic disease [PDF]
, 2018 Background Prostate cancer (PrCa) demonstrates a heterogeneous clinical presentation ranging from largely indolent to lethal. We sought to identify a signature of rare inherited variants that distinguishes between these two extreme phenotypes ...
A Liberzon +71 more
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Dysregulation of Antiviral Helicase Pathways in Systemic Lupus Erythematosus
Frontiers in Genetics, 2014 In the autoimmune disease systemic lupus erythematosus (SLE), our normal antiviral defenses are inappropriately activated, resulting in over-activity of the type I interferon pathway.
Luciana eOliveira +4 more
doaj +1 more source
Genetic clues for predisposition to severe disease [PDF]
Nature Reviews Immunology, 2021 openaire +3 more sources
Aspectos genéticos do transtorno obsessivo-compulsivo
Brazilian Journal of Psychiatry, 2001 Since the first descriptions of obsessive-compulsive disorder (OCD), genetic factors have been implicated in the etiology of the illness. Twin studies show a high concordance rate for monozygotic twins.
Gonzalez Christina H
doaj
Association between genetic predisposition and disease burden of stroke in China: a genetic epidemiological study. [PDF]
Lancet Reg Health West Pac, 2023 Huang Q +10 more
europepmc +1 more source
HLA class II associations with rheumatic heart disease among clinically homogeneous patients in children in Latvia [PDF]
, 2003 Genetic control of immune reactions has a major role in the development of rheumatic heart disease (RHD) and differs between patients with rheumatic fever (RF).
Eglite, Jelena +5 more
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Clinicopathological characteristics of histiocytic sarcoma affecting the central nervous system in dogs. [PDF]
, 2020 BackgroundHistiocytic sarcoma affecting the central nervous system (CNS HS) in dogs may present as primary or disseminated disease, often characterized by inflammation.
Crowe, Chelsea M +10 more
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