Investigating the role of mitochondrial haplogroups in genetic predisposition to meningococcal disease. [PDF]
PLoS ONE, 2009 Background and aimsMeningococcal disease remains one of the most important infectious causes of death in industrialized countries. The highly diverse clinical presentation and prognosis of Neisseria meningitidis infections are the result of complex host ...
Antonio Salas +5 more
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Genetic Predisposition to Cardiovascular Diseases [PDF]
International Journal of Human Genetics, 2001 Extensive clinical and statistical studies have identified several factors that increase the risk of heart disease, heart attack and stroke. Major risk factors are those that are associated with a significant increase in the risk of heart and blood vessel disease (CVD).
Dharam P. Agarwal
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Genetic predisposition to thrombophilia in inflammatory bowel disease [PDF]
Journal of Clinical Gastroenterology, 2011 Inflammatory bowel disease (IBD) is linked to a definite risk of thromboembolic events (TE), but data on the role of prothrombotic genetic mutations are conflicting.Fourteen genetic factors involved in TE pathogenesis were investigated in a homogeneous cohort of Sicilian patients with IBD with and without history of TE and in healthy controls.
BRAVATA', Ivana +7 more
core +6 more sources
Network location and clustering of genetic mutations determine chronicity in a stylized model of genetic diseases [PDF]
Scientific Reports, 2022 In a highly simplified view, a disease can be seen as the phenotype emerging from the interplay of genetic predisposition and fluctuating environmental stimuli.
Piotr Nyczka +2 more
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Genetic predisposition, Aβ misfolding in blood plasma, and Alzheimer’s disease [PDF]
Translational Psychiatry, 2021 AbstractAlzheimer’s disease is highly heritable and characterized by amyloid plaques and tau tangles in the brain. The aim of this study was to investigate the association between genetic predisposition, Aβ misfolding in blood plasma, a unique marker of Alzheimer associated neuropathological changes, and Alzheimer’s disease occurrence within 14 years ...
Hannah Stocker +10 more
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Genetic predisposition to metabolic dysfunction-associated fatty liver disease
Zdorovʹe RebenkaThe literature review highlights the issue of genetic risk factors associated with the development of metabolic dysfunction-associated fatty liver disease. Human genetic examinations revealed 132 genes among which 32 loci are strongly associated with the
O.E. Abaturov, A.O. Nikulina
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Genetic Predisposition and Disease Expression of Bipolar Disorder Reflected in Shape Changes of the Anterior Limbic Network. [PDF]
Brain Sci, 2019 Lu CF +7 more
europepmc +3 more sources
Ethical aspects of genetic predisposition to environmentally-related disease
Science of The Total Environment, 1996 Some individuals are highly susceptible to disease caused by chemical exposures and this hypersusceptibility can be genetically determined. Because biomarker technology for the determination of genetic predisposition is at the disposal of researchers, the capability therefore exists to include genetic screening in epidemiologic studies. The application
Philippe Grandjean, Marja Sorsa
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Genetic predisposition to Behcet's disease mediated by a IL10RA enhancer polymorphism [PDF]
HeliyonBackground: Several studies suggested the genetic association between IL10RA variants and susceptibility to Behcet's disease (BD). However, the precise mechanism of the association is still unknown.
Handan Tan +5 more
doaj +2 more sources
Predisposition to Neuropsychiatric Disease: Common Genetic Risk Factors
Focus, 2018 Victor I. Reus
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