Results 41 to 50 of about 185,084 (189)

CLINICAL AND GENETIC PARALLELS ALONG CELIAC DISEASE AMONG TOMSK CHILDREN

open access: yesПедиатрическая фармакология, 2007
The article is devoted to the analysis of the genetic predisposition to celiac disease. The authors studied the associations of the HLA genes and modifier genes of the immune response (interleukine 1, inter leukine 1 receptor antagonist, inter leukine 4,
E.I. Kondrat’eva   +5 more
doaj   +2 more sources

Pilot GWAS of caries in African-Americans shows genetic heterogeneity

open access: yesBMC Oral Health, 2019
Background Dental caries is the most common chronic disease in the US and disproportionately affects racial/ethnic minorities. Caries is heritable, and though genetic heterogeneity exists between ancestries for a substantial portion of loci associated ...
E. Orlova   +8 more
doaj   +1 more source

Network location and clustering of genetic mutations determine chronicity in a stylized model of genetic diseases

open access: yesScientific Reports, 2022
In a highly simplified view, a disease can be seen as the phenotype emerging from the interplay of genetic predisposition and fluctuating environmental stimuli.
Piotr Nyczka   +2 more
doaj   +1 more source

Investigating the role of mitochondrial haplogroups in genetic predisposition to meningococcal disease.

open access: yesPLoS ONE, 2009
Background and aimsMeningococcal disease remains one of the most important infectious causes of death in industrialized countries. The highly diverse clinical presentation and prognosis of Neisseria meningitidis infections are the result of complex host ...
Antonio Salas   +5 more
doaj   +1 more source

Genetic predisposition to smoking in relation to 14 cardiovascular diseases

open access: yesEuropean Heart Journal, 2020
Abstract Aims The aim of this study was to use Mendelian randomization (MR) to determine the causality of the association between smoking and 14 different cardiovascular diseases (CVDs). Methods and results Our primary genetic ...
Larsson, Susanna C   +7 more
openaire   +3 more sources

A Comprehensive Analysis of HLA-A and HLA-DR Allele Frequencies and Haplotype Associations in a Korean Population of 790 Individuals

open access: yesKorean Journal of Clinical Laboratory Science
The human leukocyte antigen (HLA) system, which is part of the major histocompatibility complex (MHC) plays a vital role in immune responses by differentiating between itself and foreign cells and antigens.
Hee-Kyung HAN   +19 more
doaj   +1 more source

Association Between IL-4 and IL-6 Expression Variants and Gastric Cancer Among Portuguese Population

open access: yesGE: Portuguese Journal of Gastroenterology, 2015
Introduction: Multiple studies have reported strong associations between Helicobacter pylori (Hp) inflammation and gastric cancer (GC) development. Altered expressions of pro/anti-inflammatory cytokines have a crucial role in Hp and GC proliferation ...
Ana Maria Sampaio   +6 more
doaj   +1 more source

Exogenous exposures shape genetic predisposition to lipids, Alzheimer’s, and coronary heart disease in the MLXIPL gene locus [PDF]

open access: hybrid, 2023
Yury Loika   +9 more
openalex   +1 more source

A tagging polymorphism in fat mass and obesity-associated (FTO) gene is associated with sepsis status in children

open access: yesRomanian Journal of Internal Medicine
Sepsis is one of the most common causes of death in patients admitted to intensive care units (ICUs). The development of sepsis is significantly influenced by genetic predisposition.
Jabandziev Petr   +15 more
doaj   +1 more source

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