Glutathione S-transferase T1 and M1 polymorphisms and risk of thyroid neoplasms [PDF]
Archive of Oncology, 2003 Background: In order to test the possibility of association between GSTT1 and M1 (glutathione S-transferase) null allele variant, in which the entire gene is absent, and the risk of TCO (thyroid carcinoma with cell oxyphilia), the case-control study was ...
Stankov Karmen +3 more
doaj +1 more source
Genetic predisposition of cholesterol gallstone disease
Annals of Hepatology, 2006 Gallstone disease (GSD) is the result of the interaction between genetic and environmental factors and it is a major disease cause of surgery with high costs to health systems. Worldwide prevalence varies according to the ethnic population suggesting that high prevalence of GSD in certain ethnic groups is due to the presence of genetic factors ...
Arturo Panduro +4 more
openaire +4 more sources
Genetic Predisposition and Inflammatory Bowel Disease [PDF]
Gastroenterology Research, 2013 Published reports demonstrated finding of different susceptible mutant alleles in association with inflammatory bowel disease (CD/UC) in diseased individuals from different populations. It was then assumed that the existence of different associated mutant alleles in subjects with inflammatory bowel disease from different populations means different ...
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Family-specific, novel, deleterious germline variants provide a rich resource to identify genetic predispositions for BRCAx familial breast cancer [PDF]
, 2014 BACKGROUND: Genetic predisposition is the primary risk factor for familial breast cancer. For the majority of familial breast cancer, however, the genetic predispositions remain unknown.
Bradley Downs +11 more
core +3 more sources
Diagnostic utility of, and influence of tobacco usage and genetic predisposition on, immunoglobulin A, rheumatoid factor and anti-citrullinated peptide auto-antibodies in South African rheumatoid arthritis patients [PDF]
, 2018 Background: The immunoglobulin A isotypes of anti-cyclic citrullinated peptide antibodies (ACPA) and rheumatoid factor (RF) are associated with disease severity and progression in Caucasian rheumatoid arthritis (RA) patients, as well as with genetic ...
Ally, Mahmood +4 more
core +2 more sources
Myeloproliferative Diseases as Possible Risk Factor for Development of Chronic Thromboembolic Pulmonary Hypertension—A Genetic Study [PDF]
, 2020 Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare disease which is often caused by recurrent emboli. These are also frequently found in patients with myeloproliferative diseases.
Benjamin, Nicola +15 more
core +1 more source
Periodontal disease: a genetic perspective
Brazilian Oral Research, 2012 Periodontitis is a multifactorial disease that causes tooth loss. The complex pathogenesis of periodontitis implies the involvement of a susceptible host and a bacterial challenge.
Mario Taba Jr +2 more
doaj +1 more source
Genetic Predisposition to High Blood Pressure Associates With Cardiovascular Complications Among Patients With Type 2 Diabetes: Two Independent Studies [PDF]
, 2014 Hypertension and type 2 diabetes (T2D) commonly coexist, and both conditions are major risk factors for cardiovascular disease (CVD). We aimed to examine the association between genetic predisposition to high blood pressure and risk of CVD in individuals
Curhan, Gary C. +7 more
core +1 more source
Ethnic differences in adiposity and diabetes risk – insights from genetic studies [PDF]
, 2020 Type 2 diabetes is more common in non-Europeans and starts at a younger age and at lower BMI cut-offs. This review discusses the insights from genetic studies about pathophysiological mechanisms which determine risk of disease with a focus on the role of
Bell, J.D. +7 more
core +2 more sources
Exploring the Genetic Predisposition to Epigenetic Changes in Alzheimer’s Disease
International Journal of Molecular Sciences, 2023 Alzheimer’s disease (AD) is a prevalent type of dementia in elderly populations with a significant genetic component. The accumulating evidence suggests that AD involves a reconfiguration of the epigenetic landscape, including DNA methylation, post-translational modification of histone proteins, and chromatin remodeling.
Bryzgalov, Leonid O. +2 more
openaire +2 more sources