Understanding the Use of Genetic Predisposition in Canadian Legal Decisions [PDF]
, 2013 Since the advent of the Human Genome Project in 1989, the ethical. legal, and social implications inherent in future genetic science and its applications have worried researchers and scholars in law and ethics. Concern that the results of genetic testing
Finkler, Lilith +3 more
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Genetic cause of pulmonary veno-occlusive disease
Lung India, 2022 Pulmonary veno-occlusive disease (PVOD) is an important cause of pulmonary arterial hypertension (PAH) and is classified under idiopathic cause of PAH. Over a period of time, PVOD has been studied in detail in the western countries and various diagnostic
Kaustubh Mohite, Anil Kumar Sapare
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Moderate- to low-risk variant alleles of cutaneous malignancies and nevi: lessons from genome-wide association studies [PDF]
, 2009 Cutaneous malignancies, especially malignant melanoma, exhibit great genetic heterogeneity. As a result, some individuals and families have particularly increased risk due to genetic predisposition to the disease.
Tsao, Hensin, Udayakumar, Durga
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Exome Chip Analysis of 14,026 Koreans Reveals Known and Newly Discovered Genetic Loci Associated with Type 2 Diabetes Mellitus [PDF]
Diabetes & Metabolism Journal, 2021 Background Most loci associated with type 2 diabetes mellitus (T2DM) discovered to date are within noncoding regions of unknown functional significance. By contrast, exonic regions have advantages for biological interpretation.
Seong Beom Cho +3 more
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Erythrocytes in multiple sclerosis: forgotten contributors to the pathophysiology? [PDF]
, 2016 Multiple sclerosis (MS) is an autoimmune disease characterised by lymphocytic infiltration of the central nervous system and subsequent destruction of myelin and axons. On the background of a genetic predisposition to autoimmunity, environmental triggers
Groen, Kira +5 more
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Biology, 2023 We addressed the question of the influence of the molecular polymorphism of cytokines from different T helper subsets on the susceptibility to SARS-CoV-2 infection. From a cohort of 527 samples (collected from 26 May 2020 to 31 March 2022), we focused on
Marius Saal +4 more
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Prospective study of the link between overweight/obesity and diabetes incidence among Mexican older adults: 2001-2012 [PDF]
, 2015 OBJECTIVE: To prospectively assess the relationship between overweight/obesity and incidence of type 2 diabetes mellitus (T2DM) among Mexicans aged 50+, assessing effects of age, genetic predisposition,education,physical activity,and place of residence ...
Beltrán-Sánchez, Hiram, Pinto, Guido
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Gene Polymorphisms in FAS (Rs3740286 and Rs4064) Are Involved in Endometriosis Development in Brazilian Women, but not those in CASP8 (rs13416436 and rs2037815) [PDF]
Revista Brasileira de Ginecologia e Obstetrícia, 2018 Objective The present study aims to investigate the association between caspase-8 (CASP8) (rs13416436 and rs2037815) and Fas cell surface death receptor (FAS) (rs3740286 and rs4064) polymorphisms with endometriosis in Brazilian women.
Cristina Wide Pissetti +3 more
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Lessons From Pediatric MDS: Approaches to Germline Predisposition to Hematologic Malignancies
Frontiers in Oncology, 2022 Pediatric myelodysplastic syndromes (MDS) often raise concern for an underlying germline predisposition to hematologic malignancies, referred to as germline predisposition herein.
Serine Avagyan, Akiko Shimamura
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Genetic predisposition to smoking in relation to 14 cardiovascular diseases
European Heart Journal, 2020 Abstract Aims The aim of this study was to use Mendelian randomization (MR) to determine the causality of the association between smoking and 14 different cardiovascular diseases (CVDs). Methods and results Our primary genetic ...
Scott M. Damrauer +10 more
openaire +4 more sources