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Genetics of Drug Resistance [PDF]

open access: yesEpilepsia, 2005
Summary:  Drug resistance in epilepsy affects about a third of patients and is an important clinical problem, associated with increased morbidity and mortality. It is important to consider carefully the definition of drug resistance. Recent interest in the field has focused on the potential molecular mechanisms underlying drug resistance. Environmental
openaire   +2 more sources

Dynamic expression of miRNAs across immature and adult stages of the malaria mosquito Anopheles stephensi

open access: yesParasites & Vectors, 2015
Background MicroRNAs are small non-coding RNAs that are involved in various biological processes including insect development. Anopheles stephensi serves as primary vector of malaria parasite in Asia and exhibits holometabolous life cycle that involves ...
Shanu Jain   +4 more
doaj   +1 more source

Genetics of Antimicrobial Resistance

open access: yesAnimal Biotechnology, 2006
Antimicrobial resistant strains of bacteria are an increasing threat to animal and human health. Resistance mechanisms to circumvent the toxic action of antimicrobials have been identified and described for all known antimicrobials currently available for clinical use in human and veterinary medicine. Acquired bacterial antibiotic resistance can result
H, Harbottle   +3 more
openaire   +2 more sources

Anopheles gambiae Genome Conservation as a Resource for Rational Gene Drive Target Site Selection

open access: yesInsects, 2021
The increase in molecular tools for the genetic engineering of insect pests and disease vectors, such as Anopheles mosquitoes that transmit malaria, has led to an unprecedented investigation of the genomic landscape of these organisms.
Nace Kranjc   +3 more
doaj   +1 more source

Dual Host and Pathogen RNA-Seq Analysis Unravels Chicken Genes Potentially Involved in Resistance to Highly Pathogenic Avian Influenza Virus Infection

open access: yesFrontiers in Immunology, 2021
Highly pathogenic avian influenza viruses (HPAIVs) cause severe systemic disease and high mortality rates in chickens, leading to a huge economic impact in the poultry sector. However, some chickens are resistant to the disease.
Albert Perlas   +12 more
doaj   +1 more source

Exploring Mechanisms of Quantitative Resistance to Leptosphaeria maculans (Blackleg) in the Cotyledons of Canola (Brassica napus) Based on Transcriptomic and Microscopic Analyses

open access: yesPlants, 2020
Using resistant cultivars is a common approach to managing blackleg of canola/rapeseed caused by Leptosphaeria maculans (Lm). Quantitative resistance (QR), as opposed to major-gene resistance, is of interest because it is generally more durable, due to ...
Michelle Hubbard, Chun Zhai, Gary Peng
doaj   +1 more source

Genetics of Resistance to Tetraethyllead [PDF]

open access: yesAustralian Journal of Biological Sciences, 1979
A Drosophila melanogaster population was exposed for 25 generations to 60 pg tetraethyllead per gram of medium. Selection over this period resulted in an increase in fecundity, hatchability and larva-to-adult viability. Chromosome assay showed that response in these traits was generally under additive genetic control in conformity with existing results
openaire   +2 more sources

Creating genetic resistance to HIV [PDF]

open access: yesCurrent Opinion in Immunology, 2012
HIV/AIDS remains a chronic and incurable disease, in spite of the notable successes of combination antiretroviral therapy. Gene therapy offers the prospect of creating genetic resistance to HIV that supplants the need for antiviral drugs. In sight of this goal, a variety of anti-HIV genes have reached clinical testing, including gene-editing enzymes ...
John C, Burnett   +2 more
openaire   +2 more sources

Augmenting the Sustainability of Vegetable Cropping Systems by Configuring Rootstock-Dependent Rhizomicrobiomes that Support Plant Protection

open access: yesAgronomy, 2020
Herbaceous grafting is a propagation method largely used in solanaceous and cucurbit crops for enhancing their agronomic performances especially under (a)biotic stress conditions.
Mariateresa Cardarelli   +4 more
doaj   +1 more source

Integrated omics-based exploration for temperature stress resilience: An approach to smart grape breeding strategies

open access: yesPlant Stress
Crop resilience measures must be strengthened in response to the global climate impact. Temperature stress exacerbates the impact on crop growth and grain yield, threatening the sustainability of grapevine production and dependent wine industries. Grape (
Vivek Yadav   +9 more
doaj   +1 more source

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