Results 221 to 230 of about 942,879 (267)
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1994
Drug resistance is an ever present, dark shadow of cancer chemotherapy. Resistance developing as a consequence of treatment with cancer chemotherapeutic agents was a phenomenon recognized at the outset. In the days when the genome was generally considered to be static or fixed, tumor-cell drug resistance occurring in the patient, in animal models, and ...
J L, Biedler, B A, Spengler
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Drug resistance is an ever present, dark shadow of cancer chemotherapy. Resistance developing as a consequence of treatment with cancer chemotherapeutic agents was a phenomenon recognized at the outset. In the days when the genome was generally considered to be static or fixed, tumor-cell drug resistance occurring in the patient, in animal models, and ...
J L, Biedler, B A, Spengler
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Genetics of antiepileptic drug resistance
Current Opinion in Neurology, 2009Drug resistance is an important clinical problem in epilepsy, affecting a substantial number of patients globally. Mechanisms underlying drug resistance need to be understood to develop rational therapies. Genetics offers one route to better understanding, and thus potentially treating, drug resistance.Several important advances in epilepsy genomics ...
Sanjay M, Sisodiya, Carla, Marini
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Genetics of insulin resistance
Experimental and Clinical Endocrinology & Diabetes, 2009Even among young, healthy individuals, there is more than a 10-fold variation in insulin sensitivity; however, taken in combination, all the known modifiers of insulin sensitivity - including obesity and a variety of environmental factors - explain less than one third of this variation.
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Aspirin Resistance and Genetic Polymorphisms
Journal of Thrombosis and Thrombolysis, 2002Differences in genetic makeup or polymorphisms can affect individual drug response. Detecting genetic variation may help predict how a patient will respond to a drug and could be used as a tool to select optimal therapy, tailor dosage regimens, and improve clinical outcomes. The data are replete relative to the therapeutic efficacy of aspirin (ASA) for
Josie A, Cambria-Kiely +1 more
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Genetic Selection for Mastitis Resistance
Veterinary Clinics of North America: Food Animal Practice, 2018Mastitis is a prevalent and costly disease on dairy farms. Improved management and hygiene can reduce the risk of infection by contagious or environmental pathogens, and genetic selection can confer permanent improvement in mastitis resistance. National veterinary recording systems in the Nordic countries have allowed direct selection for sire families
Kent A, Weigel, George E, Shook
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Genetics of Plant Virus Resistance
Annual Review of Phytopathology, 2005Genetic resistance to plant viruses has been used for at least 80 years to control agricultural losses to viral diseases. To date, hundreds of naturally occurring genes for resistance to plant viruses have been reported from studies of both monocot and dicot crops, their wild relatives, and the plant model, Arabidopsis.
Byoung-Cheorl, Kang +2 more
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Comparative genetics of warfarin resistance
Hämostaseologie, 2014SummaryWarfarin and other 4-hydroxycoumarinbased oral anticoagulants targeting vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1) are administered to humans, mice and rats with different purposes in mind – to act as pesticides in high-dosage baits for killing rodents, but also to save lives when administered in low dosages as antithrombotic ...
J, Oldenburg +4 more
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Genetic Resistance to Marek’s Disease
2001Marek’s disease (MD) is economically one of the most significant diseases in chickens (Purchase 1985). It is of interest that numerous estimates of heritability of resistance to MD are relatively high compared to the resistance to other diseases in chickens or other diseases in domestic livestock.
L D, Bacon, H D, Hunt, H H, Cheng
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GENETIC RESISTANCE TO MAREK'S DISEASE*
Australian Veterinary Journal, 1976A programme to control MD by genetic selection was tested by selecting breeding sires and dams whose progeny were found to have above average resistance to MD following inoculation at day old with infectious material. Under conditions of natural exposure, Australorp pullets from parents selected for resistance had a lower incidence of MD lesions than ...
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Genetically Controlled Resistance to Viruses
1983Historically, the first demonstrations of the existence of host genes that could control resistance to disease induced by an animal virus were reported independently by Lynch and Hughes (1) and Webster and Clow (2) in 1936. Subsequently, a number of other genes have been identified in various strains of inbred mice, each of which confers resistance to ...
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