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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye +11 more
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Genetic aspects of multidrug resistance
Medical Oncology and Tumor Pharmacotherapy, 1992Gene amplification is responsible both for dihydrofolate reductase induced methotrexate resistance, and for the P-glycoprotein encoding multigene family induced multidrug resistance. The 6 pairs of hydrophobic regions of the P-glycoprotein fold up in a snake-like structure through the lipidic layers of the cell membrane. Other detoxification mechanisms
M, Pauly, F, Ries, M, Dicato
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Genetics of metabolic resistance
Mathematical Biosciences, 2016Herbicide resistance has become a major issue for many weeds. Metabolic resistance refers to the biochemical processes within organisms that degrade herbicides to less toxic compounds, resulting in a shift of the dose response curve. This type of resistance involves polygenic inheritance.
Richter, Otto +2 more
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Genetics of insulin resistance
Current Diabetes Reports, 2002Insulin resistance, defined as the decreased ability of insulin to perform its biological functions, is likely to represent the primary physiologic defect underlying the insulin resistance syndrome (IRS), which includes insulin resistance/hyperinsulinemia, glucose intolerance and/or type 2 diabetes mellitus, visceral obesity, hypertension, and ...
Maria M, Mercado +3 more
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Genetic resistance to flaviviruses
2003Resistance to flavivirus-induced disease in mice was first discovered in the 1920s and was subsequently shown to be controlled by the resistant allele of a single dominant autosomal gene. While the majority of current laboratory mouse stains have a homozygous-susceptible phenotype, the resistant allele has been found to segregate in wild mouse ...
Margo A, Brinton, Andrey A, Perelygin
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1994
Drug resistance is an ever present, dark shadow of cancer chemotherapy. Resistance developing as a consequence of treatment with cancer chemotherapeutic agents was a phenomenon recognized at the outset. In the days when the genome was generally considered to be static or fixed, tumor-cell drug resistance occurring in the patient, in animal models, and ...
J L, Biedler, B A, Spengler
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Drug resistance is an ever present, dark shadow of cancer chemotherapy. Resistance developing as a consequence of treatment with cancer chemotherapeutic agents was a phenomenon recognized at the outset. In the days when the genome was generally considered to be static or fixed, tumor-cell drug resistance occurring in the patient, in animal models, and ...
J L, Biedler, B A, Spengler
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Genetics of antiepileptic drug resistance
Current Opinion in Neurology, 2009Drug resistance is an important clinical problem in epilepsy, affecting a substantial number of patients globally. Mechanisms underlying drug resistance need to be understood to develop rational therapies. Genetics offers one route to better understanding, and thus potentially treating, drug resistance.Several important advances in epilepsy genomics ...
Sanjay M, Sisodiya, Carla, Marini
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Genetics of insulin resistance
Experimental and Clinical Endocrinology & Diabetes, 2009Even among young, healthy individuals, there is more than a 10-fold variation in insulin sensitivity; however, taken in combination, all the known modifiers of insulin sensitivity - including obesity and a variety of environmental factors - explain less than one third of this variation.
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Aspirin Resistance and Genetic Polymorphisms
Journal of Thrombosis and Thrombolysis, 2002Differences in genetic makeup or polymorphisms can affect individual drug response. Detecting genetic variation may help predict how a patient will respond to a drug and could be used as a tool to select optimal therapy, tailor dosage regimens, and improve clinical outcomes. The data are replete relative to the therapeutic efficacy of aspirin (ASA) for
Josie A, Cambria-Kiely +1 more
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Genetic Selection for Mastitis Resistance
Veterinary Clinics of North America: Food Animal Practice, 2018Mastitis is a prevalent and costly disease on dairy farms. Improved management and hygiene can reduce the risk of infection by contagious or environmental pathogens, and genetic selection can confer permanent improvement in mastitis resistance. National veterinary recording systems in the Nordic countries have allowed direct selection for sire families
Kent A, Weigel, George E, Shook
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