Results 51 to 60 of about 942,879 (267)

The influence of glutathione metabolism on alkaline adaptation of Amur ide (Leuciscus waleckii) and potential role of gut microbiota

Animal Microbiome
Amur ide (Leuciscus waleckii), which inhabits Lake Dali, a soda lake in Northeast China with extremely high alkalinity (~ 53.57 mmol/L) and pH value (~ 9.6), is considered to be an ideal model for elucidating alkaline adaption mechanisms.
Zou Yuting, Li Chenghao, Huang Jing, Yang Haochen, Luo Liang, Liew Honjung, Chang Yumei   +6 more
doaj   +1 more source

Exploring the Genetic Potential for Multi-Resistance to Rust and Other Coffee Phytopathogens in Breeding Programs

Plants
The application of marker-assisted selection in coffee breeding programs accelerates the identification and concentration of target alleles, being essential for developing cultivars resistant to multiple diseases.
Bruna Lopes Mariz, Eveline Teixeira Caixeta, Marcos Deon Vilela de Resende, Antônio Carlos Baião de Oliveira, Dênia Pires de Almeida, Danúbia Rodrigues Alves   +5 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

A prospective cohort observational study investigating the association between the United Kingdom digital dermatitis genetic index and the disease prevalence in a population of Holstein heifers

Journal of Dairy Science
: The digital dermatitis index (DDI), a genetic index for digital dermatitis (DD) resistance has been previously associated with presence of DD in Holstein cows.
Alkiviadis Anagnostopoulos, Matthew Barden, Lara Robinson, Nektarios Siachos, Ana Sato, Kaixin Bao, Evangelos Lamprou, Amy Gillespie, Androniki Psifidi, Georgios Banos, Georgios Oikonomou   +10 more
doaj   +1 more source

Reaction of corn lines to bacterial leaf streak [PDF]

Pesquisa Agropecuária Brasileira
The objective of this work was to select experimental corn lines genetically resistant to the bacterial leaf streak caused by Xanthomonas vasicola pv. vasculorum, in two growing seasons. The treatments were carried out in an experimental randomized block
Francine Lautenchleger, Marcos Ventura Faria, Cacilda Marcia Duarte Rios Faria, Leandro Alvarenga Santos, Glaici Kelly Pereira, Clara Oliveira Prestes   +5 more
doaj   +1 more source

Genetics of multidrug resistance. [PDF]

Journal of Clinical Investigation, 1988
Despite major advances in the treatment of cancer, resistance to multiple chemotherapeutic agents remains a major cause of treatment failure. Some tumors are initially resistant to many ofthe most active antineoplastic agents. Other tumors that are initially sensitive to cytotoxic agents often recur and frequently develop resistance to a broad range ...
J M, Croop, P, Gros, D E, Housman
openaire   +2 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Histological and transcriptome analysis uncover a robust early PTI and ETI-associated immune response in Musa acuminata subsp. burmannica accession ‘Calcutta 4’ to Fusarium oxysporum f. sp. cubense Subtropical Race 4

Frontiers in Plant Science
IntroductionBanana (Musa spp.) is a globally significant crop and a staple food in the diet of millions of people. However, commercial cultivars are highly susceptible to Fusarium wilt, a devastating disease caused by Fusarium oxysporum f. sp.
Érica de Castro Costa, Lucas Santos Bastos, Andresa Priscila de Souza Ramos, Leandro de Souza Rocha, Edson Perito Amorim, Claudia Fortes Ferreira, Nicola Vergara Lopes Serão, Roberto Coiti Togawa, Priscila Grynberg, Robert Neil Gerard Miller   +9 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source