Results 51 to 60 of about 7,418,451 (334)

Trends in insulin resistance: insights into mechanisms and therapeutic strategy

Signal Transduction and Targeted Therapy, 2022
The centenary of insulin discovery represents an important opportunity to transform diabetes from a fatal diagnosis into a medically manageable chronic condition.
Mengwei Li, Xiaowei Chi, Ying Wang, Sarra Setrerrahmane, Wenwei Xie, Hanmei Xu   +5 more
semanticscholar   +1 more source

Nutritional and Behavioral Intervention for Long‐Term Childhood Acute Leukemia Survivors With Metabolic Syndrome

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Metabolic syndrome (MetS) is a common complication in survivors of childhood acute lymphoblastic and myeloid leukemia (AL), and a major risk factor for premature cardiovascular disease, type‐2‐diabetes, and metabolic dysfunction‐associated steatotic liver disease (MASLD).
Visentin Sandrine, Béliard Sophie, Renard Cécile, Caussy Cyrielle, Hamidou Zeinab, Romano David, Gacem Mélanie, Petit Arnaud, Saultier Paul, Borentain Patrick, Michel Gérard   +10 more
wiley   +1 more source

Mining candidate genes for grape seed traits based on a genome-wide association study

Horticultural Plant Journal
Seedlessness has always been a valuable quality characteristic of edible grape varieties. Although the production of seedless grapes has been ongoing for decades, the genetic complexity of seedless grapes is not yet fully understood.
Chuan Zhang, Yameng Yang, Songlin Zhang, Vivek Yadav, Haixia Zhong, Fuchun Zhang, Xiaoming Zhou, Xinyu Wu, Xue Cao, Liwen Cui   +9 more
doaj   +1 more source

Combined genetic and genomic approaches to characterize a durable Hevea resistance to South American leaf blight : S01T07 [PDF]

, 2013
The South American Leaf Blight (SALB), due to the Ascomycota Microcyclus ulei, threatens the world production of natural rubber, based on the cultivation of nearly only one species: the tropical tree Hevea brasiliensis.
Berger, Angélique, Doare, Fabien, Déon, Marine, Garcia, Dominique, Koop, Daniela Martins, Le Guen, Vincent, Pujade-Renaud, Valérie, Rippel, L.S., Rivallan, Ronan, Seguin, Marc   +9 more
core  

Targeting substrate-site in Jak2 kinase prevents emergence of genetic resistance

Scientific Reports, 2015
Emergence of genetic resistance against kinase inhibitors poses a great challenge for durable therapeutic response. Here, we report a novel mechanism of JAK2 kinase inhibition by fedratinib (TG101348) that prevents emergence of genetic resistance.
M. Kesarwani, E. Huber, Zachary Kincaid, Chris R. Evelyn, J. Biesiada, M. Rance, M. Thapa, N. Shah, J. Meller, Yi Zheng, M. Azam   +10 more
semanticscholar   +1 more source

Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches

Frontiers in Oncology, 2022
Cancer is one of the leading causes of death worldwide. Several treatments are available for cancer treatment, but many treatment methods are ineffective against multidrug-resistant cancer.
T. Emran, Asif Shahriar, Aar Rafi Mahmud, Tanjilur Rahman, Mehedy Hasan Abir, Mohd. Faijanur - Rob Siddiquee, Hossain Ahmed, Nova Rahman, F. Nainu, Elly Wahyudin, Saikat Mitra, K. Dhama, Mahmoud M. Habiballah, S. Haque, A. Islam, M. Hassan   +15 more
semanticscholar   +1 more source

The MedSupport Multilevel Intervention to Enhance Support for Pediatric Medication Adherence: Development and Feasibility Testing

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction We developed MedSupport, a multilevel medication adherence intervention designed to address root barriers to medication adherence. This study sought to explore the feasibility and acceptability of the MedSupport intervention strategies to support a future full‐scale randomized controlled trial.
Elizabeth G. Bouchard, Hital Patel, Paula C. Vincent, Justine Kahn, Kira Bona, Thai Hoa Tran, Elisa M. Rodriguez, Kristopher Attwood, Kara M. Kelly   +8 more
wiley   +1 more source

A haplotype-resolved genome provides insight into allele-specific expression in wild walnut (Juglans regia L.)

Scientific Data
Wild germplasm resources are crucial for gene mining and molecular breeding because of their special trait performance. Haplotype-resolved genome is an ideal solution for fully understanding the biology of subgenomes in highly heterozygous species. Here,
Liqun Han, Xiang Luo, Yu Zhao, Ning Li, Yuhui Xu, Kai Ma   +5 more
doaj   +1 more source

Sugar transporters: mediators of carbon flow between plants and microbes

Frontiers in Plant Science
Pathogens and symbiotic microorganisms significantly influence plant growth and crop productivity. Enhancing crop disease resistance and maximizing the beneficial role of symbiotic microorganisms in agriculture constitute critical areas of scientific ...
Mengyu Lei, Mengyu Lei, Xiaodi Wang, Kuan Chen, Qianqian Wei, Miaomiao Zhou, Gong Chen, Shuai Su, Yuying Tai, Kexin Zhuang, Dexiao Li, Mengjuan Liu, Senlei Zhang, Youning Wang   +13 more
doaj   +1 more source

Correlation between blast resistance in wheat cultivars and conidia sporulation rate of Pyricularia oryzae Triticum

Ciência Rural, 2023
: The use of resistant wheat cultivars is a fundamental strategy to minimize the damages caused by blast, a disease caused by the fungus Pyricularia oryzae Triticum (PoT).
João Leodato Nunes Maciel, Marcos Kovaleski, Daniela da Silva, Julia Negrão Cavalheiro, Cláudia Cristina Clebsch, Carolina Cardoso Deuner   +5 more
doaj   +1 more source