Results 71 to 80 of about 656,003 (247)

Use of plant genetic resources in Yemen and suggestions for potential improvement

Genetic Resources
The study aimed to determine the present state of the use of plant genetic resources in Yemen during the period 2007–2023 and to identify potential improvements, relying on historical descriptive information as well as on primary and secondary ...
Maeen Aljarmouzi, Khalil M Alsharjabi, Ahmed Amri   +2 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The German Federal Ex Situ Genebank for Agricultural and Horticultural Crops – Conservation, exploitation and steps towards a bio-digital resource centre

Genetic Resources
Over more than 80 years, the collections of the German Federal Ex Situ Genebank for Agricultural and Horticultural Crops have grown to around 152,000 accessions of 3,000 species preserved at three locations: Gatersleben, Groß Lüsewitz and Malchow/Poel ...
Stephan Weise, Frank R. Blattner, Andreas Börner, Klaus J. Dehmer , Marion Grübe , Dörte Harpke , Ulrike Lohwasser , Markus Oppermann , Nils Stein , Evelin Willner , Manuela Nagel   +10 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Agro-morphological and molecular characterization of Argentine maize (Zea mays L.) landraces of ‘Cristalino Colorado’ race

Genetic Resources
Despite the high variability of Argentine maize (Zea mays L.) landraces, they are scarcely used by breeders due to the limited knowledge available about the genetic merit of these materials.
Raquel Alicia Defacio, Natalia Mercedes Paz, Ana Rosa Schlater, Marcelo Edmundo Ferrer, Sergio Jorge Bramardi   +4 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Editorial: Ex situ conservation of plant genetic resources in Europe – A journey through history, mission, challenges and future opportunities

Genetic Resources
The Special Issue entitled: ‘Ex situ conservation of plant genetic resources in Europe – A journey through history, mission, challenges and future opportunities’ presents 16 original articles, including 11 genebank reports from 7 European countries ...
Filippo Guzzon, Sandra Goritschnig, Nora Capozio, Lorenzo Maggioni   +3 more
doaj   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

Novel germplasm of tepary and other Phaseolus bean wild relatives from dry areas of southwestern USA

Genetic Resources
Heat and drought stresses threaten global bean production. Additional genetic resources are needed in genebanks for future improvement of bean crops through breeding for tolerance. The USA southwestern Sky Island mountains contain such genetic resources
Daniel G. Debouck, Richard C. Pratt, Sarah Dohle, Timothy Porch, Marcela Santaella, Luis Guillermo Santos, Milan O. Urban   +6 more
doaj   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source