Results 81 to 90 of about 726,790 (246)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

1. Genetic engineering: The new techniques and their potential

California Agriculture, 1982
Not available – first paragraph follows: In one sense, genetic engineering of plants is really nothing new. Since the beginnings of agriculture, when crop species were first domesticated, people have modified plants to suit their needs.
C Meredith
doaj  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Preimplantational genetic diagnosis: an actual alternative with future implications [PDF]

MedUNAB, 2005
Preimplantational genetic diagnosis (PGT) isa new technique, promoted as an alternative for prenatal diagnosisand eventually for the voluntary termination of pregnancy whenthe couple is willing .
Claudia Juliana Serrano Serrano
doaj  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Phloretin-nanospanlastics for targeting the Akt/PI3K signaling pathways in dimethylhydrazine-induced colon cancer in mice

International Journal of Pharmaceutics: X
Objectives: Colorectal cancer is the third most common cancer worldwide, accounting for approximately 10 % of all cancer cases. It is also the second leading cause of cancer-related deaths globally.
Ebtsam A. Abdel-Wahab, Zahraa Haleem Al-Qaim, Ahmed T.H. Faris Al-Karkhi, Aysam M. Fayed, Ahmed M. Eldmrdash, Mohammed Abdalla Hussein, Amal Abdel-Aziz, Azza M. Metwaly, Heba.G. Abdelzaher, M.A. Abdelzaher, Diana A. ALsherif   +10 more
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Correction: Diet of the brown bear in Himalaya: Combining classical and molecular genetic techniques. [PDF]

PLoS One, 2020
Nawaz MA, Valentini A, Khan NK, Miquel C, Taberlet P, Swenson JE.   +5 more
europepmc   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

THE SPECIATION IN GENETIC ALGORITHMS FOR PRESERVING POPULATION DIVERSITY AND OPTIMIZATION OF FUNCTIONS WITH SUBOPTIMAL SOLUTIONS

Електроніка та інформаційні технології
Background. Genetic algorithms are used in various tasks and show advantages compared to other optimization methods, which may not always be applicable. However, there are cases when they can’t provide the best possible solution.
V. Pretsel, Roman Shuvar
doaj   +1 more source