Results 101 to 110 of about 17,080,653 (424)
Genetic testing and surveillance guidelines in hereditary pheochromocytoma and paraganglioma
Journal of Internal Medicine, 2018 Pheochromocytoma and paraganglioma (PPGL) are rare tumours and at least 30% are part of hereditary syndromes. Approximately 20% of hereditary PPGL are caused by pathogenic germ line variants in genes of the succinate dehydrogenase complex (SDHx), TMEM127
A. Muth +9 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
Privacy-Preserving Genetic Relatedness Test [PDF]
arXiv, 2016 An increasing number of individuals are turning to Direct-To-Consumer (DTC) genetic testing to learn about their predisposition to diseases, traits, and/or ancestry. DTC companies like 23andme and Ancestry.com have started to offer popular and affordable ancestry and genealogy tests, with services allowing users to find unknown relatives and long ...
arxiv
A Semi-Supervised Generative Adversarial Network for Prediction of Genetic Disease Outcomes [PDF]
arXiv, 2020 For most diseases, building large databases of labeled genetic data is an expensive and time-demanding task. To address this, we introduce genetic Generative Adversarial Networks (gGAN), a semi-supervised approach based on an innovative GAN architecture to create large synthetic genetic data sets starting with a small amount of labeled data and a large
arxiv
Patient Attitudes Toward Genetic Testing for Inherited Predispositions to Hematologic Malignancies [PDF]
, 2018 Although inherited predispositions to hematologic malignancies have previously been considered extremely rare, approximately 12 causative genes have been implicated in the last decade.
Beecroft, Taylor
core +1 more source
The Bottleneck in Genetic Testing [PDF]
Circulation Research, 2015 Progress in science is a continuum but not uniform. Occasional sparks, typically ignited by the so-called disruptive discoveries, decorate the continuum. Relevant to this editorial on advances in the genetic testing technologies, is the disruptive technology of capillary sequencing, also known as Sanger sequencing.1 It enabled the initial sequencing of
openaire +3 more sources
Cascade Genetic Testing of Relatives for Hereditary Cancer Risk: Results of an Online Initiative
Journal of the National Cancer Institute, 2018 In cascade testing, genetic testing for an identified familial pathogenic variant extends to disease-free relatives to allow genetically targeted disease prevention.
Jennifer L. Caswell-Jin +5 more
semanticscholar +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
To Warn or Not to Warn? Genetic Information, Families, and Physician Liability
McGill Journal of Medicine, 2020 Genetic testing raises a number of legal issues. Physicians providing genetic testing may be faced with questions related to privacy, confidentiality, and the duty to warn.
Jennifer L Gold
doaj +1 more source
Context, ethics and pharmacogenetics [PDF]
, 2006 Most of the literature on pharmacogenetics assumes that the main problems in implementing the technology will be institutional ones (due to funding or regulation) and that although it involves genetic testing, the ethical issues involved in ...
Adam M. Hedgecoe +58 more
core +1 more source