Results 101 to 110 of about 1,824,368 (348)
Cyclic nucleotide signaling as a drug target in retinitis pigmentosa
FEBS Letters, EarlyView.Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää +2 more
wiley +1 more source
Frontiers in GeneticsSex discordance between cell-free DNA (cfDNA) testing and ultrasound examination is rare but can cause significant patient discomfort and uncertainty.
Nuria Balaguer +6 more
doaj +1 more source
TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation
FEBS Letters, EarlyView.TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling +4 more
wiley +1 more source
MOLECULAR IDENTIFICATION OF ROOT-KNOT NEMATODES MELOIDOGYNE SPP. ISOLATED FROM CUCUMBER FARMS IN DIFFERENT IRAQI REGIONS [PDF]
مجلة الأنبار للعلوم الزراعيةMeloidogyne spp. is one of the most common crop diseases globally. Due to the similarity in morphological features between various Meloidogyne spp., molecular techniques were used to identify their species.
M. R. Abbas +2 more
doaj +1 more source
On the valuation of genetic tests [PDF]
Personalized Medicine, 2004 10.1517/17410541.1.1.125 © 2 Continuing progress in the field of human genetics may lead to more widespread use of genetic screening in medicine. While hundreds of publications have so far reported the identification of novel genetic disease risk factors and genetic mediators of treatment response, only a few FDA-approved genetic tests are presently ...
openaire +3 more sources
Bayesian Model Comparison in Genetic Association Analysis: Linear Mixed Modeling and SNP Set Testing [PDF]
, 2015 We consider the problems of hypothesis testing and model comparison under a flexible Bayesian linear regression model whose formulation is closely connected with the linear mixed effect model and the parametric models for SNP set analysis in genetic ...
Wen, Xiaoquan
core
Rejoinder: Quantifying the Fraction of Missing Information for Hypothesis Testing in Statistical and Genetic Studies [PDF]
, 2011 Rejoinder to "Quantifying the Fraction of Missing Information for Hypothesis Testing in Statistical and Genetic Studies" [arXiv:1102.2774]Comment: Published in at http://dx.doi.org/10.1214/08-STS244REJ the Statistical Science (http://www.imstat.org/sts/
Kong, Augustine +2 more
core +2 more sources
FEBS Letters, EarlyView.Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu +17 more
wiley +1 more source
Continuous salt stress-induced long non-coding RNAs and DNA methylation patterns in soybean roots
BMC Genomics, 2019 Background Environmental stimuli can activate a series of physiological and biochemical responses in plants accompanied by extensive transcriptional reprogramming.
Rui Chen +7 more
doaj +1 more source
FEBS Letters, EarlyView.Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria +3 more
wiley +1 more source