Results 101 to 110 of about 1,948,626 (333)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

An experimental test of the mutation-selection balance model for the maintenance of genetic variance in fitness components [PDF]

, 2017
Nathaniel P. Sharp, Aneil F. Agrawal
openalex   +1 more source

Genetic Testing When There is a Mix of Compulsory and Voluntary Health Insurance [PDF]

Genetic insurance can deal with the negative effects of genetic testing on insurance coverage and income distribution when the insurer has access to information about test status. Hence, efficient testing is promoted.
Michael Hoel, Tor Iversen
core  

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Association of Genetic Testing Results With Mortality Among Women With Breast Cancer or Ovarian Cancer

, 2021
Allison W. Kurian, Paul Abrahamse, Irina Bondarenko, Ann S. Hamilton, Dennis Deapen, Scarlett Lin Gomez, Monica Morrow, Jonathan S. Berek, Timothy P. Hofer, Steven J. Katz, Kevin C. Ward   +10 more
openalex   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Corrigendum: A novel BRCA1 splicing variant detected in an early onset triple-negative breast cancer patient additionally carrying a pathogenic variant in ATM: a case report

Frontiers in Oncology, 2023
Mara Colombo, Patrizia Mondini, Elisa Minenza, Claudia Foglia, Annamaria Mosconi, Carmen Molica, Lorenza Pistola, Vienna Ludovini, Paolo Radice   +8 more
doaj   +1 more source

Tell me y: anticipation of sex discrepancies in cell-free DNA testing due to maternal genetic abnormalities: a case report

Frontiers in Genetics
Sex discordance between cell-free DNA (cfDNA) testing and ultrasound examination is rare but can cause significant patient discomfort and uncertainty.
Nuria Balaguer, Emilia Mateu-Brull, Jose Antonio Martínez-Conejero, Ana Cervero, Roser Navarro, Jorge Jiménez-Almazán, Miguel Milán   +6 more
doaj   +1 more source

TOGAPS: A Testability Oriented Genetic Algorithm For Pipeline Synthesis [PDF]

, 1996
C.P. Ravikumar, Vaibhav Saxena
openalex   +1 more source

Comment: Quantifying the Fraction of Missing Information for Hypothesis Testing in Statistical and Genetic Studies

, 2011
Comment on "Quantifying the Fraction of Missing Information for Hypothesis Testing in Statistical and Genetic Studies" [arXiv:1102.2774]Comment: Published in at http://dx.doi.org/10.1214/08-STS244A the Statistical Science (http://www.imstat.org/sts ...
Lo, Shaw-Hwa, Zheng, Tian
core   +1 more source