Results 61 to 70 of about 17,080,653 (424)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Genome wide identification of novel DNA methylation driven prognostic markers in colorectal cancer

Scientific Reports
Colorectal cancer (CRC) stands as a major contributor to cancer-related fatalities within China. There is an urgent need to identify accurate biomarkers for recurrence predicting in CRC.
Yuhua Ma, Yuanxin Li, Zhahong Wen, Yining Lai, Kulaixijiang Kamila, Jing Gao, Wang-yang Xu, Chengxiang Gong, Feifan Chen, Liuqing Shi, Yunzhi Zhang, Hanzhang Chen, Min Zhu   +12 more
doaj   +1 more source

Epidemiology and Risk Factors for Carbapenem-Resistant Klebsiella Pneumoniae and Subsequent MALDI-TOF MS as a Tool to Cluster KPC-2-Producing Klebsiella Pneumoniae, a Retrospective Study

Frontiers in Cellular and Infection Microbiology, 2020
Background: Carbapenem-resistant Klebsiella pneumoniae (CRKP) appeared recently and now presents a particularly critical problem to hospitalized patients worldwide.
Lili Fang, Lili Fang, Lili Fang, Heping Xu, Heping Xu, Heping Xu, Xiaoying Ren, Xiaoying Ren, Xiaoying Ren, Xun Li, Xun Li, Xun Li, Xiaobo Ma, Xiaobo Ma, Xiaobo Ma, Haijian Zhou, Haijian Zhou, Guolin Hong, Guolin Hong, Guolin Hong, Xianming Liang, Xianming Liang   +21 more
doaj   +1 more source

Outcomes of Genetic Testing in a Genitourinary Genetics Clinic [PDF]

, 2018
Several known hereditary cancer syndromes confer an increased risk for genitourinary (GU)related malignancies. Various guidelines indicate when to refer patients to genetic counseling for GU-related hereditary cancer syndromes but there is limited ...
Pace, Annelise
core   +1 more source

Diphthamide synthesis is linked to the eEF2‐client chaperone machinery

FEBS Letters, EarlyView.
The diphthamide modification of eukaryotic translation elongation factor 2 (eEF2) is important for accurate protein synthesis. We addressed the potential coordination of de novo eEF2 synthesis with simultaneous or subsequent diphthamide modification. Our work reveals that the co‐chaperones Hgh1 and Cpr7, which are known to support folding of nascent ...
Lars Kaduhr, Klaus Mayer, Raffael Schaffrath, Johannes Buchner, Ulrich Brinkmann   +4 more
wiley   +1 more source

Conservative management of giant retroperitoneal hematoma after cesarean section in severe preeclampsia: a rare case report

BMC Pregnancy and Childbirth
Background Spontaneous retroperitoneal hematoma (RPH) after cesarean section is an extremely rare disease with various causes, which can lead to unexplained maternal shock and death. Because cases of RPH are extremely rare in obstetric settings, there is
Jingwen Yu, Mengge Ke, Guangming Wang
doaj   +1 more source

Autoinflammatory Reaction in Dogs Treated for Cancer via G6PD Inhibition

Case Reports in Veterinary Medicine, 2017
Glucose-6-phosphate dehydrogenase (G6PD) is an oncoprotein that is overexpressed in cancer cells to provide the NADPH required for their increased anabolism. NADPH, sourced from G6PD fuels nucleotide biosynthesis, maintains redox potential of thioredoxin
Jonathan W. Nyce
doaj   +1 more source

Texas Physicians\u27 Awareness and Utilization of Genetic Services [PDF]

, 2015
The number of disorders for which genetic testing is available has increased nearly 500% in the past 15 years. Access to the majority of genetic tests and services hinges on physicians’ ability to identify patients at risk for genetic disease and provide
Jenevein, Callie L
core   +1 more source

Genetic testing of children for adult-onset conditions: opinions of the British adult population and implications for clinical practice

, 2014
This study set out to explore the attitudes of a representative sample of the British public towards genetic testing in children to predict disease in the future. We sought opinions about genetic testing for adult-onset conditions for which no prevention/
A Clarke, A Jolly, Angela Fenwick, Anneke M Lucassen, BA Bernhardt, D Craufurd, DC Wertzdagger, E Campbell, FS Collins, G Eysenbach, GJ Meissen, I Balfour-Lynn, JC Sapp, JM Taber, L Henneman, ME Fallat, O Järvinen, O Järvinen, P Borry, P Borry, P Borry, R Rhodes, RE Duncan, S Dalby, S Robertson, S Shkedi-Rafid, Sandi Dheensa, Shiri Shkedi-Rafid   +27 more
core   +1 more source

Consensus Guidelines on Genetic` Testing for Hereditary Breast Cancer from the American Society of Breast Surgeons

Annals of Surgical Oncology, 2019
The purpose of this consensus guideline is to outline recommendations for genetic testing that medical professionals can use to assess hereditary risk for breast cancer.
E. Manahan, H. Kuerer, M. Sebastian, K. Hughes, J. Boughey, D. Euhus, S. Boolbol, Walton A Taylor   +7 more
semanticscholar   +1 more source