Results 61 to 70 of about 1,948,626 (333)

Gene expression-based dissection of inter-histotypes, intra-histotype and intra-tumor heterogeneity in pediatric tumors

Scientific Reports, 2022
Intra-tumor heterogeneity (ITH) fosters tumor evolution, resistance to therapy, and relapse. Recently, many evidence have been accumulated on the occurrence of genetic ITH in pediatric cancers.
Sara Ciceri, Andrea Carenzo, Maria Federica Iannó, Alessia Bertolotti, Carlo Morosi, Roberto Luksch, Filippo Spreafico, Paola Collini, Paolo Radice, Maura Massimino, Loris De Cecco, Daniela Perotti   +11 more
doaj   +1 more source

Efficacy and Tolerability of Topotecan/Cyclophosphamide/Dinutuximab in Relapsed and Refractory High‐Risk Neuroblastoma: A Multi‐Institutional Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Chemoimmunotherapy with irinotecan, temozolomide, and dinutuximab (I/T/DIN) has emerged as first‐line therapy for relapsed/refractory (r/r) high‐risk neuroblastoma (HRNB) in North America. Topotecan and cyclophosphamide (T/C) are often used in combination with dinutuximab in the setting of lack of response, progression, or incomplete ...
Benjamin J. Lerman, Madeleine King, Rajen Mody, Sara‐Jane Onyeama, Araz Marachelian, Thomas Cash, Sara M. Federico, Meaghan Granger, Ami V. Desai, Suzanne Shusterman, Jennifer H. Foster, Elizabeth Sokol, Chelsee Greer, Keri Streby, Holly J. Meany, Kieuhoa T. Vo, Margaret E. Macy, Rochelle Bagatell   +17 more
wiley   +1 more source

A light-controlled one-tube detection platform combining CRISPR-Cas12a and RPA: an innovative approach for rapid diagnosis of Acinetobacter baumannii

Frontiers in Bioengineering and Biotechnology
BackgroundAcinetobacter baumannii (A. baumannii) is a significant pathogen associated with nosocomial infections, predominantly affecting immunocompromised patients, and is linked to high mortality rates.
Zihan Zhou, Zihan Zhou, Zihan Zhou, Zihan Zhou, Zihan Zhou, Lele Pan, Lele Pan, Lele Pan, Lele Pan, Lele Pan, Shihua Luo, Shihua Luo, Shihua Luo, Shihua Luo, Shihua Luo, Jiangmei Ma, Jiangmei Ma, Jiangmei Ma, Jiangmei Ma, Jiangmei Ma, Baoyan Ren, Baoyan Ren, Lina Liang, Lina Liang, Lina Liang, Lina Liang, Lina Liang, Xuebin Li, Xuebin Li, Xuebin Li, Xuebin Li, Guijiang Wei, Guijiang Wei, Guijiang Wei, Guijiang Wei, Guijiang Wei, Guijiang Wei   +36 more
doaj   +1 more source

Ethical qualms about genetic prognosis [PDF]

, 2016
The debate about direct-to-consumer genetic testing has centred on whether consumers are the best judges of their own clinical care. Inthis article, I also examine whether the science of personalized medicine is really as advanced as its proponents
Dickenson, Donna
core   +1 more source

Clinical Course and Impact of Breaks in Therapy for Children With Relapsed/Refractory Solid Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Pediatric relapsed or refractory (R/R) solid tumors carry a dismal prognosis, and postrelapse patient experiences are not well described. We present postrelapse outcomes, including number of R/R events and subsequent therapy regimens.
Matthew T. McEvoy, Elizabeth L. Seashore, W. Susan Cheng, Shondra Clay, Jessica A. Casas, Jennifer H. Foster   +5 more
wiley   +1 more source

The gut microbiota–brain axis in neurological disorders

MedComm
Previous studies have shown a bidirectional communication between human gut microbiota and the brain, known as the microbiota–gut–brain axis (MGBA). The MGBA influences the host's nervous system development, emotional regulation, and cognitive function ...
Mingming You, Nan Chen, Yuanyuan Yang, Lingjun Cheng, Hongzhang He, Yanhua Cai, Yating Liu, Haiyue Liu, Guolin Hong   +8 more
doaj   +1 more source

Comparison of analytical performance and economic value of two biosurveillance methods for tracking SARS-COV-2 variants of concern

Microbiology Spectrum
The development of biosurveillance programs with strong analytical performance and economically accessible protocols is essential for monitoring viral pathogens.
Nicholas P. Pinkhover, Kerriann M. Pontbriand, Kelli P. Fletcher, Eduardo Sanchez, Kenneth Okello, Liam M. Garvey, Alex Pum, Kurvin Li, Gabriel DeOliveira, Teddie Proctor, Jelena D. M. Feenstra, Océane Sorel, Manoj Gandhi, Jared R. Auclair   +13 more
doaj   +1 more source

Autoinflammatory Reaction in Dogs Treated for Cancer via G6PD Inhibition

Case Reports in Veterinary Medicine, 2017
Glucose-6-phosphate dehydrogenase (G6PD) is an oncoprotein that is overexpressed in cancer cells to provide the NADPH required for their increased anabolism. NADPH, sourced from G6PD fuels nucleotide biosynthesis, maintains redox potential of thioredoxin
Jonathan W. Nyce
doaj   +1 more source

Epidemiology and Risk Factors for Carbapenem-Resistant Klebsiella Pneumoniae and Subsequent MALDI-TOF MS as a Tool to Cluster KPC-2-Producing Klebsiella Pneumoniae, a Retrospective Study

Frontiers in Cellular and Infection Microbiology, 2020
Background: Carbapenem-resistant Klebsiella pneumoniae (CRKP) appeared recently and now presents a particularly critical problem to hospitalized patients worldwide.
Lili Fang, Lili Fang, Lili Fang, Heping Xu, Heping Xu, Heping Xu, Xiaoying Ren, Xiaoying Ren, Xiaoying Ren, Xun Li, Xun Li, Xun Li, Xiaobo Ma, Xiaobo Ma, Xiaobo Ma, Haijian Zhou, Haijian Zhou, Guolin Hong, Guolin Hong, Guolin Hong, Xianming Liang, Xianming Liang   +21 more
doaj   +1 more source

Role of Preimplantation genetic testing in Indian women with advanced maternal age to optimize Reproductive Outcomes [PDF]

, 2022
Krishna Mantravadi, Durga Gedela Rao, Beena Rawat, Pooja Chauhan   +3 more
openalex   +1 more source