Results 71 to 80 of about 1,972,073 (332)
FEBS Letters, EarlyView.Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez +3 more
wiley +1 more source
Problematizing consent: searching genetic genealogy databases for law enforcement purposes
New Genetics and Society, 2021 Genetic genealogy databases have become particularly attractive to law enforcement agencies, especially in the United States (US), which have started to employ genealogists to search them with unknown origin DNA from unidentified human remains (suicides,
G. Samuel, D. Kennett
doaj +1 more source
Privacy-Preserving Genetic Relatedness Test [PDF]
arXiv, 2016 An increasing number of individuals are turning to Direct-To-Consumer (DTC) genetic testing to learn about their predisposition to diseases, traits, and/or ancestry. DTC companies like 23andme and Ancestry.com have started to offer popular and affordable ancestry and genealogy tests, with services allowing users to find unknown relatives and long ...
arxiv
A Semi-Supervised Generative Adversarial Network for Prediction of Genetic Disease Outcomes [PDF]
arXiv, 2020 For most diseases, building large databases of labeled genetic data is an expensive and time-demanding task. To address this, we introduce genetic Generative Adversarial Networks (gGAN), a semi-supervised approach based on an innovative GAN architecture to create large synthetic genetic data sets starting with a small amount of labeled data and a large
arxiv
FEBS Letters, EarlyView.Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek +15 more
wiley +1 more source
Safety assessment of Polyhexamethylene biguanide [PDF]
International Journal of Medical Device and Adjuvant Treatments, 2019 OBJECTIVE: The use of antiseptics in the treatment of genital infections has become a systematic alternative to antibiotics. Their use has been also supported for the treatment of virus-induced genital infections.
B. Orrù +3 more
doaj +1 more source
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
"23andMe confirms: I'm super white" -- Analyzing Twitter Discourse On Genetic Testing [PDF]
arXiv, 2018 Recent progress in genomics is bringing genetic testing to the masses. Participatory public initiatives are underway to sequence the genome of millions of volunteers, and a new market is booming with a number of companies like 23andMe and AncestryDNA offering affordable tests directly to consumers.
arxiv
Genetic Testing\u27s Soft Underbelly : Christian Vision and Bio-Utopia [PDF]
, 2001 To distinguish genetic testing\u27s positive aspects from its downsides, we who work in Catholic health care must begin examining these new technologies in the light of our faith tradition.
Lysaught, M. Therese
core +2 more sources
Searching for invariants using genetic programming and mutation testing [PDF]
, 2011 Invariants are concise and useful descriptions of a program's behaviour. As most programs are not annotated with invariants, previous research has attempted to automatically generate them from source code.
Clark, J.A., Ratcliff, S., White, D.R.
core +1 more source