Results 81 to 90 of about 17,080,653 (424)

Comparison of analytical performance and economic value of two biosurveillance methods for tracking SARS-COV-2 variants of concern

Microbiology Spectrum
The development of biosurveillance programs with strong analytical performance and economically accessible protocols is essential for monitoring viral pathogens.
Nicholas P. Pinkhover, Kerriann M. Pontbriand, Kelli P. Fletcher, Eduardo Sanchez, Kenneth Okello, Liam M. Garvey, Alex Pum, Kurvin Li, Gabriel DeOliveira, Teddie Proctor, Jelena D. M. Feenstra, Océane Sorel, Manoj Gandhi, Jared R. Auclair   +13 more
doaj   +1 more source

Population testing for cancer predisposing BRCA1/BRCA2 mutations [PDF]

, 2014
Background: Technological advances raise the possibility of systematic population-based genetic testing for cancer-predisposing mutations, but it is uncertain whether benefits outweigh disadvantages.
Wardle, J
core  

Non-invasive preimplantation genetic testing (niPGT): the next revolution in reproductive genetics?

Human Reproduction Update, 2019
BACKGROUND Preimplantation genetic testing (PGT) encompasses methods that allow embryos to be tested for severe inherited conditions or for chromosome abnormalities, relevant to embryo health and viability.
Megan Leaver, D. Wells
semanticscholar   +1 more source

Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones

FEBS Letters, EarlyView.
Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley   +1 more source

The gut microbiota–brain axis in neurological disorders

MedComm
Previous studies have shown a bidirectional communication between human gut microbiota and the brain, known as the microbiota–gut–brain axis (MGBA). The MGBA influences the host's nervous system development, emotional regulation, and cognitive function ...
Mingming You, Nan Chen, Yuanyuan Yang, Lingjun Cheng, Hongzhang He, Yanhua Cai, Yating Liu, Haiyue Liu, Guolin Hong   +8 more
doaj   +1 more source

A Quantitative Test of Population Genetics Using Spatio-Genetic Patterns in Bacterial Colonies [PDF]

The American Naturalist 178, 538 (2011), 2011
It is widely accepted that population genetics theory is the cornerstone of evolutionary analyses. Empirical tests of the theory, however, are challenging because of the complex relationships between space, dispersal, and evolution. Critically, we lack quantitative validation of the spatial models of population genetics.
arxiv   +1 more source

Genetic Testing for Pheochromocytoma [PDF]

Current Hypertension Reports, 2010
Pheochromocytomas (PHEOs) and paragangliomas (PGLs) are rare, catecholamine-producing tumors that are usually sporadic. However, about 30% of these tumors have been identified as being of inherited origin. To date, nine genes have been confirmed as participating in PHEO or PGL tumorigenesis.
Zdenek Frysak, Karel Pacak, David Karasek   +2 more
openaire   +3 more sources

Underdiagnosis of Hereditary Breast Cancer: Are Genetic Testing Guidelines a Tool or an Obstacle?

Journal of Clinical Oncology, 2018
Purpose An estimated 10% of breast and ovarian cancers result from hereditary causes. Current testing guidelines for germ line susceptibility genes in patients with breast carcinoma were developed to identify carriers of BRCA1/2 variants and have evolved
P. Beitsch, P. Whitworth, K. Hughes, Rakesh R. Patel, B. Rosen, G. Compagnoni, P. Baron, R. Simmons, L. Smith, I. Grady, M. Kinney, C. Coomer, K. Barbosa, D. Holmes, E. Brown, L. Gold, Patricia Clark, L. Riley, S. Lyons, A. Ruíz, S. Kahn, H. Macdonald, L. Curcio, M. K. Hardwick, Shan Yang, E. Esplin, R. Nussbaum   +26 more
semanticscholar   +1 more source

Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp

FEBS Letters, EarlyView.
LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra, Paul Weiland, Pauline Anka Plitzko, Julia Thiery, Laura Czech, Felix Willmund, Patricia Bedrunka, Gert Bange   +7 more
wiley   +1 more source

DIEANet: an attention model for histopathological image grading of lung adenocarcinoma based on dimensional information embedding

Scientific Reports
Efficient and rapid auxiliary diagnosis of different grades of lung adenocarcinoma is conducive to helping doctors accelerate individualized diagnosis and treatment processes, thus improving patient prognosis. Currently, there is often a problem of large
Zexin Wang, Jing Gao, Min Li, Enguang Zuo, Chen Chen, Cheng Chen, Fei Liang, Xiaoyi Lv, Yuhua Ma   +8 more
doaj   +1 more source