Results 81 to 90 of about 1,972,073 (332)
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
To Warn or Not to Warn? Genetic Information, Families, and Physician Liability
McGill Journal of Medicine, 2020 Genetic testing raises a number of legal issues. Physicians providing genetic testing may be faced with questions related to privacy, confidentiality, and the duty to warn.
Jennifer L Gold
doaj +1 more source
Applying Genetic Algorithm for Prioritization of Test Case Scenarios Derived from UML Diagrams [PDF]
arXiv, 2014 Software testing involves identifying the test cases whichdiscover errors in the program. However, exhaustive testing ofsoftware is very time consuming. In this paper, a technique isproposed to prioritize test case scenarios by identifying the critical path clusters using genetic algorithm.
arxiv
Patient Attitudes Toward Genetic Testing for Inherited Predispositions to Hematologic Malignancies [PDF]
, 2018 Although inherited predispositions to hematologic malignancies have previously been considered extremely rare, approximately 12 causative genes have been implicated in the last decade.
Beecroft, Taylor
core +1 more source
Ethical qualms about genetic prognosis [PDF]
, 2016 The debate about direct-to-consumer genetic testing has centred on whether consumers are the best judges of their own clinical care. Inthis article, I also examine whether the science of personalized medicine is really as advanced as its proponents
Dickenson, Donna
core +1 more source
FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source
AtmosphereUrban air pollution, especially from heavy metal (HM) contamination, poses significant risks to human health and environmental sustainability. This study investigates the spatial and temporal distribution of HM contamination in Thessaloniki, Greece ...
Themistoklis Sfetsas +5 more
doaj +1 more source
Clinical and molecular characterization of a cardiac ryanodine receptor founder mutation causing catecholaminergic polymorphic ventricular tachycardia [PDF]
, 2015 Background Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a difficult-to-diagnose cause of sudden cardiac death (SCD). We identified a family of 1400 individuals with multiple cases of CPVT, including 36 SCDs during youth.
Allegue, Catarina +12 more
core +2 more sources
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
"And We Will Fight For Our Race!" A Measurement Study of Genetic Testing Conversations on Reddit and 4chan [PDF]
arXiv, 2019 Progress in genomics has enabled the emergence of a booming market for "direct-to-consumer" genetic testing. Nowadays, companies like 23andMe and AncestryDNA provide affordable health, genealogy, and ancestry reports, and have already tested tens of millions of customers.
arxiv