Results 91 to 100 of about 7,750,425 (359)

Innovative Strategies for Hearing Loss Treatment

Quality in Sport
Introduction: Hearing loss significantly impacts patients' quality of life, making it an increasingly common issue, particularly among the elderly. Hearing loss is assessed based on the sound intensity threshold in decibels, ranging from mild (21–40
Krystian Żuk, Alicja Góral, Kamila Duszyńska, Karol Dolepski, Michał Czachajda   +4 more
doaj   +1 more source

Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy

Molecular Cancer, 2020
Epigenetics is dynamic and heritable modifications to the genome that occur independently of DNA sequence. It requires interactions cohesively with various enzymes and other molecular components.
Yuanjun Lu, Y. Chan, H. Tan, Sha Li, Ning Wang, Yibin Feng   +5 more
semanticscholar   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Clinical Application of Noninvasive Prenatal Testing in Singleton Pregnancy with and without in vitro Fertilization: A 6-year Observational Study at a Single Tertiary Center

International Journal of Women's Health
Qian Zhang,* Yuhong Guo,* Bin Liang, Meihuan Chen, Xiaoqing Wu, Na Lin, Hailong Huang, Liangpu Xu Department of Medical Genetic Diagnosis and Therapy Center, Fujian Key Laboratory for Prenatal Diagnosis and Birth Defect, Fujian Maternity ...
Zhang Q, Guo Y, Liang B, Chen M, Wu X, Lin N, Huang H, Xu L   +7 more
doaj  

Therapeutic vascularization in regenerative medicine

Stem Cells Translational Medicine, 2020
Therapeutic angiogenesis, that is, the generation of new vessels by delivery of specific factors, is required both for rapid vascularization of tissue‐engineered constructs and to treat ischemic conditions.
Roberto Gianni‐Barrera, Nunzia Di Maggio, Ludovic Melly, Maximilian G. Burger, Edin Mujagic, Lorenz Gürke, Dirk J. Schaefer, Andrea Banfi   +7 more
doaj   +1 more source

Iron-overload injury and cardiomyopathy in acquired and genetic models is attenuated by resveratrol therapy

Scientific Reports, 2015
Iron-overload cardiomyopathy is a prevalent cause of heart failure on a world-wide basis and is a major cause of mortality and morbidity in patients with secondary iron-overload and genetic hemochromatosis.
Subhash K. Das, Wang Wang, P. Zhabyeyev, R. Basu, Brent A. McLean, D. Fan, N. Parajuli, Jessica DesAulniers, Vaibhav B. Patel, R. Hajjar, J. Dyck, Z. Kassiri, G. Oudit   +12 more
semanticscholar   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Genetic Therapy Approaches for Ornithine Transcarbamylase Deficiency. [PDF]

Biomedicines, 2023
Seker Yilmaz B, Gissen P.
europepmc   +1 more source