Results 131 to 140 of about 8,660,824 (403)

A phenome-wide Mendelian randomization analysis reveals the genetical associations of myocardial infarction, angina pectoris and Alzheimer’s disease with lung cancer

Scientific Reports
Lung cancer is a complex disease with varying subtypes. The genetic architectures and risk factors that are similar or distinct among these subtypes remain unclear.
Haiwei Wang, Xinrui Wang, Na Lin, Yingying Lin, Liangpu Xu   +4 more
doaj   +1 more source

Genetic therapy in a mitochondrial disease model suggests a critical role for liver dysfunction in mortality. [PDF]

Elife, 2022
Sabharwal A, Wishman MD, Cervera RL, Serres MR, Anderson JL, Holmberg SR, Kar B, Treichel AJ, Ichino N, Liu W, Yang J, Ding Y, Deng Y, Lacey JM, Laxen WJ, Loken PR, Oglesbee D, Farber SA, Clark KJ, Xu X, Ekker SC.   +20 more
europepmc   +1 more source

Epigenetic Consequences of Genome Manipulations: Caveats for Human Germline Therapy and Genetically Modified Organisms [PDF]

, 2019
Walter Doerfler
openalex   +1 more source

SUBPOPULATION HETEROGENEITY OF NK CELLS DURING THE GENETIC MODIFICATION FOR SUBSEQUENT USE IN TARGETED THERAPY

, 2023
Maria A. Streltsova, Anna A. Boyko, Maria O. Ustiuzhanina, Anastasia I. Palamarchuk, N. A. Alekseeva, R. A. Velichinskii, Julia D. Vavilova, М. В. Гречихина, Alexander M. Sapozhnikov, С. М. Деев, Elena I. Kovalenko   +10 more
openalex   +2 more sources

Designing Lentiviral Vectors for Gene Therapy of Genetic Diseases [PDF]

, 2021
Valentina Poletti, Fulvio Mavilio
openalex   +1 more source

Liquid Hydroxyurea (Xromi) for Children With Sickle Cell Anemia: A New Solution Compounding Existing Problems

Pediatric Blood &Cancer, EarlyView.
Alexandra Power‐Hays, Charles T. Quinn
wiley   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Correction: Systematic review and meta-analysis determining the benefits of in vivo genetic therapy in spinal muscular atrophy rodent models. [PDF]

Gene Ther, 2023
Chilcott EM, Muiruri EW, Hirst TC, Yáñez-Muñoz RJ.   +3 more
europepmc   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Antisense Oligonucleotide (AON)-based Therapy for Leber Congenital Amaurosis Caused by a Frequent Mutation in CEP290

Molecular Therapy: Nucleic Acids, 2012
Leber congenital amaurosis (LCA) is the most severe form of inherited retinal degeneration, with an onset in the first year of life. The most frequent mutation that causes LCA, present in at least 10% of individuals with LCA from North-American and ...
Rob WJ Collin, Anneke I den Hollander, Saskia D van der Velde-Visser, Jeannette Bennicelli, Jean Bennett, Frans PM Cremers   +5 more
doaj   +1 more source