Results 151 to 160 of about 8,605,496 (403)

Highly Bioadaptable Hybrid Conduits with Spatially Bidirectional Structure for Precision Nerve Fiber Regeneration via Gene Therapy

Advanced Science
Peripheral nerve deficits give rise to motor and sensory impairments within the limb. The clinical restoration of extensive segmental nerve defects through autologous nerve transplantation often encounters challenges such as axonal mismatch and ...
Renliang Zhao, Xiangtian Deng, Jizhao Dong, Chen Liang, Xiaozhong Yang, Yunfeng Tang, Juan Du, Zilu Ge, Dong Wang, Yifan Shen, Lianghua Jiang, Wei Lin, Tonghe Zhu, Guanglin Wang   +13 more
doaj   +1 more source

Comparative Effectiveness of Intracerebroventricular, Intrathecal, and Intranasal Routes of AAV9 Vector Administration for Genetic Therapy of Neurologic Disease in Murine Mucopolysaccharidosis Type I. [PDF]

Front Mol Neurosci, 2021
Belur LR, Romero M, Lee J, Podetz-Pedersen KM, Nan Z, Riedl MS, Vulchanova L, Kitto KF, Fairbanks CA, Kozarsky KF, Orchard PJ, Frey WH, Low WC, McIvor RS.   +13 more
europepmc   +1 more source

The new (liberal) eugenics [PDF]

Despite the Nazi horrors, in 1953 the new eugenics was founded, when Watson and Crick postulated the double helix of DNA as the basis of chemical heredity.
Sfetcu, Nicolae
core  

Genetic screening for single-cell variability modulators driving therapy resistance [PDF]

, 2019
Eduardo A. Torre, Eri Arai, Sareh Bayatpour, Lauren E. Beck, Benjamin Emert, Sydney M. Shaffer, Ian A. Mellis, Mitchell E. Fane, Gretchen M. Alicea, Krista A. Budinich, Ashani T. Weeraratna, Junwei Shi, Arjun Raj   +12 more
openalex   +1 more source

Genetic and immunological therapy for cancer [PDF]

Journal of the Royal Society of Medicine, 2000
A, Young, D J, Kerr
openaire   +2 more sources

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Susceptible genetic polymorphisms and their association with adverse effects of orlistat therapy

, 2021
Rajan Logesh, Arun Radhakrishnan, Gobi Selleppan, Suresh K. Mohankumar   +3 more
openalex   +2 more sources

Author Correction: Complex genetic signatures in immune cells underlie autoimmunity and inform therapy

Nature Genetics, 2020
V. Orrù, M. Steri, C. Sidore, Michele Marongiu, Valentina Serra, S. Olla, G. Sole, Sandra Lai, Mariano Dei, A. Mulas, Francesca Virdis, M. Piras, M. Lobina, Mara Marongiu, Maristella Pitzalis, F. Deidda, A. Loizedda, Stefano Onano, M. Zoledziewska, S. Sawcer, M. Devoto, M. Gorospe, G. Abecasis, M. Floris, Mauro Pala, D. Schlessinger, E. Fiorillo, F. Cucca   +27 more
semanticscholar   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source