Results 181 to 190 of about 7,770,494 (359)

In Vitro Study of Encapsulation Therapy for Fabry Disease Using Genetically Engineered CHO Cell Line [PDF]

, 2002
Yasunori Naganawa, K. Ohsugi, Ryoichi Kase, Isao Date, Hitoshi Sakuraba, Norio Sakuragawa   +5 more
openalex   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Generation and Treatment of a Novel Severe Model of Visceral Gaucher Disease by Genetic Therapy. [PDF]

Pharmaceutics
Geard AF, Massaro G, Hughes MP, Arbuthnot P, Waddington SN, Rahim AA.   +5 more
europepmc   +1 more source

Correction of a Genetic Defect by Nuclear Transplantation and Combined Cell and Gene Therapy [PDF]

, 2002
William M. Rideout, Konrad Hochedlinger, Michael Kyba, George Q. Daley, Rudolf Jaenisch   +4 more
openalex   +1 more source

Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials

The Lancet, 2015
J. Mega, N. Stitziel, J. G. Smith, D. Chasman, M. Caulfield, James J Devlin, F. Nordio, Craig L. Hyde, Christopher P. Cannon, Frank M Sacks, Neil R. Poulter, P. Sever, P. Ridker, E. Braunwald, O. Melander, S. Kathiresan, M. Sabatine   +16 more
semanticscholar   +1 more source

The influence of ROS1 fusion partners and resistance mechanisms in ROS1‐TKI‐treated non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
This real‐world study of ROS1+ NSCLC highlights fusion diversity, treatment outcomes with crizotinib and lorlatinib, and in vitro experiments with resistance mechanisms. G2032R drives strong resistance to ROS1‐targeted TKIs, especially lorlatinib. Fusion partner location does not affect overall survival to crizotinib or lorlatinib. Findings support the
Fenneke Zwierenga, Christa Dijkhuizen, Patrick Korthuis, Wim Timens, Harry Groen, Jeroen Hiltermann, Anke van den Berg, Lyndsay Drayer, Anthonie van der Wekken   +8 more
wiley   +1 more source

Topical miRNA Delivery via Elastic Liposomal Formulation: A Promising Genetic Therapy for Cutaneous Lupus Erythematosus (CLE). [PDF]

Int J Mol Sci
Joseph-Mullol B, Royo M, Preat V, Moliné T, Ferrer B, Aparicio G, Cortés-Hernández J, Solé C.   +7 more
europepmc   +1 more source

Genetic Disease in Offspring of Long-Term Survivors of Childhood and Adolescent Cancer Treated with Potentially Mutagenic Therapies [PDF]

, 2002
Marvin L. Meistrich, Julianne Byrne
openalex   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Development of Cardiovascular Disease Therapeutics Using Space Environment: Opportunities and Challenges

Hanggong uju uihakoeji
As research on the unique effects of space environment, especially microgravity and cosmic radiation, on the cardiovascular system is being conducted, research on the development of cardiovascular therapeutics using the space environment is attracting
Hyelim Park, Kyu-Sung Kim
doaj   +1 more source