Results 181 to 190 of about 8,660,824 (403)

Biosafety Evaluation of a Chimeric Adenoviral Vector in Mini-Pigs: Insights into Immune Tolerance and Gene Therapy Potential

Biomedicines
Background: The biosafety of gene therapy products remains a major challenge to their introduction into the clinic. In particular, the problem of immunogenicity of viral vectors is the focus of attention.
Andrei Izmailov, Irina Minyazeva, Vage Markosyan, Zufar Safiullov, Ilnaz Gazizov, Ilnur Salafutdinov, Maria Markelova, Ravil Garifulin, Maksim Shmarov, Denis Logunov, Rustem Islamov, Vadim Pospelov   +11 more
doaj   +1 more source

A comprehensive evaluation of interaction between genetic variants and use of menopausal hormone therapy on mammographic density [PDF]

, 2015
Anja Rudolph, Peter A. Fasching, Sabine Behrens, Ursula Eilber, Manjeet K. Bolla, Qin Wang, Deborah J. Thompson, Kamila Czene, Judith S. Brand, Jingmei Li, Christopher G. Scott, V. Shane Pankratz, Kathleen R. Brandt, Emily Hallberg, Janet E. Olson, Adam Lee, Matthias W. Beckmann, Arif B. Ekici, Lothar Haeberle, Gertraud Maskarinec, Loı̈c Le Marchand, Fredrick R. Schumacher, Roger L. Milne, Julia A. Knight, Carmel Apicella, Melissa C. Southey, Miroslav Kapuscinski, John L. Hopper, Irene L. Andrulis, Graham G. Giles, Christopher A. Haiman, Kay‐Tee Khaw, Robert Luben, Per Hall, Paul D.P. Pharoah, Fergus J. Couch, Douglas F. Easton, Isabel dos‐Santos‐Silva, Celine M. Vachon, Jenny Chang‐Claude   +39 more
openalex   +1 more source

supplementary Figures S1-S10 from Genetic Events That Limit the Efficacy of MEK and RTK Inhibitor Therapies in a Mouse Model of KRAS-Driven Pancreatic Cancer

, 2023
Piergiorgio Pettazzoni, Andrea Viale, Parantu K. Shah, Alessandro Carugo, Haoqiang Ying, Huamin Wang, Giannicola Genovese, Sahil Seth, Rosalba Minelli, Tessa Green, Emmet Huang-Hobbs, Denise Corti, Nora Sánchez, Luigi Nezi, Matteo Marchesini, Avnish Kapoor, Wantong Yao, Maria Emilia Di Francesco, Alessia Petrocchi, Angela K. Deem, Kenneth Scott, Simona Colla, Gordon B. Mills, Jason B. Fleming, Timothy P. Heffernan, Philip Jones, Carlo Toniatti, Ronald A. DePinho, Giulio Draetta   +28 more
openalex   +2 more sources

[Genetic therapy of cancer].

Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion, 2002
Gene therapy is a new modality of treatment in which a gene is used to modify or add new biochemical properties to a patient's target cells with therapeutics purposes. Currently, this experimental therapy is under intensive development as an alternative to treat cancer, because it is possible that this therapy may generate a higher antineoplastic ...
Augusto, Rojas-Martínez, Irma Alicia, Martínez-Dávila, Andrés, Hernández-García, Estuardo, Aguilar-Córdova, Hugo Alberto, Barrera-Saldaña   +4 more
openaire   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

KRONİK AĞRIDA GENETİK TEDAVİ VE HEMŞİRENİN ROLÜ

Sakarya Üniversitesi Holistik Sağlık Dergisi, 2019
Kronik ağrı, insidansı yüksek olan önemli sağlık sorunlarından biridir. Kronik ağrı bireyin yaşam kalitesini olumsuz etkilemekte, immun sistemi baskılama, anksiyete, depresyon ve intihara eğilim gibi ciddi komplikasyonlara yol açmaktadır.
Kübra Yılmaz, Sema Koçaşlı
doaj  

Aspects of genetic imprinting: implications, syndromes and therapies [PDF]

Nada A Hassan
openalex   +1 more source

Neuroprotective therapies in glaucoma: II. Genetic nanotechnology tools [PDF]

, 2015
Nafiseh Nafissi, Marianna Földvári
openalex   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source