Results 251 to 260 of about 8,660,824 (403)

Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy

Nature Reviews. Cancer, 2016
S. Topalian, J. Taube, R. Anders, D. Pardoll   +3 more
semanticscholar   +1 more source

Beyond Nature? Genomic Modification and the Future of Humanity [PDF]

, 2018
Mahoney, Julia D., Siegal, Gil
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Pharmacogenomics of Thiopurine Drugs: A Bench-To-Bedside Success Story in Thailand. [PDF]

Clin Transl Sci
Biswas M, John S, Murad MA, Sukasem C.
europepmc   +1 more source

Genetic treatment of a molecular disorder: gene therapy approaches to sickle cell disease.

Blood, 2016
Megan D Hoban, S. Orkin, D. E. Bauer
semanticscholar   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Hereditary spastic paraplegia: from decades of therapy to future innovations. [PDF]

Ther Adv Neurol Disord
Cipriano L, Angelini C, Maria Santorelli F.   +2 more
europepmc   +1 more source

Role of host and viral factors and genetic variation of IL28B on therapy outcome in patients with chronic hepatitis C genotype 1b from Serbia

, 2019
Snežana Jovanović-Ćupić, Nina Petrović, Milena Krajnović, Maja Bundalo, Nikola Kokanov, Ana Božović, Gorana Stamenković   +6 more
openalex   +1 more source

Genetic therapies, human genetic enhancement, and … eugenics? [PDF]

Gene Therapy, 2019
openaire   +2 more sources

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source