Results 161 to 170 of about 566,900 (297)

Demographic structure and genetic variability of a population ofTestudo hermanni hermanni(Reptilia: Testudines: Testudinidae) from Southern Tuscany (Central Italy): a case of “happy-ending” uncontrolled reintroduction

, 2013
Giulia Cutuli, Marco Vannini, Sara Fratini   +2 more
openalex   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Sweet Taste Receptors' Genetic Variability in Advanced Potential Targets of Obesity. [PDF]

Nutrients
Wagner-Reguero S, Fernández LP, Colmenarejo G, Cruz-Gil S, Espinosa I, Molina S, Crespo MC, Aguilar-Aguilar E, Marcos-Pasero H, de la Iglesia R, Loria-Kohen V, Ruiz RR, Laparra-Llopis M, de Molina AR, Gómez de Cedrón M.   +14 more
europepmc   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Ostracod Genetic Variability in Response to Lake Level-Driven Salinity Dynamics in Nam Co, Central Tibetan Plateau, in the Past Two Millennia. [PDF]

Ecol Evol
Dulias K, Anslan S, Victoria Nogales L, Schwarz A, Kang W, Echeverría-Galindo P, Börner N, Peng P, Liu Y, Liu K, Wünnemann B, Wang J, Schwalb A.   +12 more
europepmc   +1 more source

Arctic Biocrusts Highlight Genetic Variability in Photosynthesis as a Key Driver of Biodiversity

Ekaterina Pushkareva, Leonie Keilholz, Sandra Kammann, Karl‐Heinz Linne von Berg, Ulf Karsten, Burkhard Becker   +5 more
openalex   +1 more source

Genetic variability studies of fruit yield and its traits among indeterminate tomato genotypes under open field condition

, 2015
Om Prakash Meena, Vijay Bahadur, Boe A, Pawan Saini   +3 more
openalex   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Genetic Variability and Prediction of T Epitopes of the HPV16 E2 Gene in Asymptomatic Women from Cajamarca, Peru. [PDF]

Viruses
Bonifacio-Velez de Villa E, Aguilar-Luis D, Denegri-Hinostroza D, Aguilar-Luis MA, Silva-Caso W, Tarazona-Castro Y, Becerra-Goicochea L, Aquino-Ortega R, Cornejo-Tapia A, Del Valle-Mendoza J.   +9 more
europepmc   +1 more source

Phenotypic and genetic variability of quality traits of carcass sides and meat

, 2006
M. Petrović, Milovan Pusic, D. Radojković, M. Mijatovic, Čedomir Radović, B. Živković   +5 more
openalex   +2 more sources