Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Life history of Monocystis parasites and genetic diversity of their hosts, the invasive Amynthas earthworms [PDF]
, 2016 Monocystis is a parasites in the phylum Apicomplexa that infects nearly 100% of earthworms; however, the parasites have low survivorship, low production of transmissible gametocysts, and seemingly lack schizogony.
Keller, Erin L.
core +1 more source
Effect of Genetic Variation in a Drosophila Model of Diabetes-Associated Misfolded Human Proinsulin [PDF]
, 2013 Bin He +12 more
openalex +1 more source
Association between serotonin 2A receptor (HTR2A) genetic variations and risk of hypertension in a community-based cohort study [PDF]
, 2020 Jung Ran Choi +2 more
openalex +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Phylogeny of the members of the genus Alburnoides in Iran using COI gene
Majallah-i ̒Ilmī-i Shīlāt-i Īrān, 2019 Up to now, twelve species of the genus Alburnoides belonged to Cyprinidae have been described from Iranian inland water solely based on the morphological characteristics.
S. Eagderi; A. Jouladeh-Roudbar; J. Imani Harsini; M. Rostami
doaj
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Accurate modeling of confounding variation in eQTL studies leads to a great increase in power to detect trans-regulatory effects [PDF]
, 2011 Expression quantitative trait loci (eQTL) studies are an integral tool to investigate the genetic component of gene expression variation. A major challenge in the analysis of such studies are hidden confounding factors, such as unobserved covariates or ...
Neil Lawrence +2 more
core +1 more source
Environment, but not genetic divergence, influences geographic variation in colour morph frequencies in a lizard [PDF]
, 2015 Claire A. McLean +2 more
openalex +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source