Results 191 to 200 of about 2,064,271 (324)

Genetic variation shapes the chromatin accessibility landscape and transcriptional responses in mouse adipose tissue. [PDF]

PLoS Genet
Mononen J, Taipale M, Malinen M, Levonen AL, Ruotsalainen AK, Norton L, Heikkinen S.   +6 more
europepmc   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Gut Microbial Genetic Variation Regulates Host Reproduction. [PDF]

Microb Biotechnol
Ding X, Wu Y, Zhou D, Gu R, Zhu T, Cai W, Ren Y, Li Y, Wang C, Tan A, Li Y, Zhu Z.   +11 more
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Exploring standing genetic variation for barley leaf rust resistance in Australian breeding panel. [PDF]

Theor Appl Genet
Pandit M, Dracatos P, Periyannan S, Lam Y, Brunner SM, Honse T, Tong J, Dinglasan E, Ganesalingam D, Moody D, Baraibar S, Hickey L, Alahmad S, Robinson H.   +13 more
europepmc   +1 more source

Genetic variation in IBD: progress, clues to pathogenesis and possible clinical utility

, 2016
Byong Duk Ye, Dermot McGovern
openalex   +2 more sources

Genetic Variation at the Human α _2B -Adrenergic Receptor Locus [PDF]

, 2005
Jason P. Etzel, Brinda K. Rana, Gen Wen, Robert J. Parmer, Nicholas J. Schork, Daniel T. O’Connor, Paul A. Insel   +6 more
openalex   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Common genetic variation influencing the human lung imaging phenotypes. [PDF]

Nat Commun
Zhu M, Du L, Shi L, Ji C, Zhu C, Song C, Wu L, Zhu L, Lu J, Zhang Q, Wu F, Jin C, Mou Y, Li Q, Zhang J, Zhu M, Cai J, Zhang C, Fu Y, Gong L, Hang D, Dai J, Jiang Y, Jin G, Hu Z, Ma H, Cheng X, Shen H.   +27 more
europepmc   +1 more source

Genetic variation of the cutaneous HPA axis: An analysis of UVB-induced differential responses

, 2013
Cezary Skobowiat, Reza Nejati, Lu Lu, Robert W. Williams, Andrzej Słomiński   +4 more
openalex   +2 more sources