Results 251 to 260 of about 2,064,271 (324)

Genetic variation among progeny shapes symbiosis in a basidiomycete with poplar. [PDF]

New Phytol
Dauphin B, de Freitas Pereira M, Croll D, Cardoso Anastácio T, Fauchery L, Guinet F, Dutra Costa M, Martin F, Peter M, Kohler A.   +9 more
europepmc   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Age-Dependent Contributions of Rare and Common Genetic Variation in Atrial Fibrillation. [PDF]

Circ Genom Precis Med
Chen Z, Aziz PF, Greenland P, Passman R, Gordon AS, Webster G.   +5 more
europepmc   +1 more source

Draft genome of Palmaria palmata and intraspecific genetic variations in the North-East Atlantic

Serena Rosignoli, Masami Inaba, Matthias Schmid, Marcus McHale, Antoine Fort, Maeve D. Edwards, Agnes Mols‐Mortensen, Roy S. Bartle, Arild Endal, Aurélien Baud, Christine A. Maggs, Ronan Sulpice   +11 more
openalex   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Endothelial KSR2 regulated by genetic variation protects against atherosclerosis through AMPKα1 stabilization. [PDF]

Theranostics
Liu M, Fu X, Zhang H, Pan J, Jia Q, Zhang C, An F.   +6 more
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Genetic variation in TMEM106B alters microglial activation and cytokine responses in chronic traumatic encephalopathy. [PDF]

Acta Neuropathol
Hartman S, Aytan N, Nicks R, Hawkins S, Cherry J, Alvarez VE, Meng G, Tripodis Y, Martin B, Palmisano J, Goldstein LE, Katz DI, Dwyer B, Daneshvar DH, Crary JF, Alosco M, Xia W, McKee AC, Mez J, Stein TD.   +19 more
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Genetic variation and heritability of haploid frailty in maize. [PDF]

Front Plant Sci
Yavuz R, Wang H, Fakude M, Dermail A, Frei UK, Liu P, Lübberstedt T.   +6 more
europepmc   +1 more source