Results 41 to 50 of about 4,784,986 (369)
BiomedicinesBackground: The biosafety of gene therapy products remains a major challenge to their introduction into the clinic. In particular, the problem of immunogenicity of viral vectors is the focus of attention.
Andrei Izmailov +11 more
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Colony polymerase chain reaction of stably transfected Trypanosoma cruzi grown on solid medium [PDF]
Memorias do Instituto Oswaldo Cruz, 2000 Tools for the genetic manipulation of Trypanosoma cruzi are largely unavailable, although several vectors for transfection of epimastigotes and expression of foreign or recombinant genes have been developed. We have previously constructed several plasmid
Wagner G dos Santos +2 more
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A simple new approach to variable selection in regression, with application to genetic fine-mapping
bioRxiv, 2018 We introduce a simple new approach to variable selection in linear regression, and to quantifying uncertainty in selected variables. The approach is based on a new model – the “Sum of Single Effects” (SuSiE) model – which comes from writing the sparse ...
Gao Wang +3 more
semanticscholar +1 more source
Beyond Gene Delivery: Strategies to Engineer the Surfaces of Viral Vectors
Biomedicines, 2013 Viral vectors have been extensively studied due to their great transduction efficiency compared to non-viral vectors. These vectors have been used extensively in gene therapy, enabling the comprehension of, not only the advantages of these vectors, but ...
Cristian Capasso +2 more
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Orientation of the genetic variance-covariance matrix and the fitness surface for multiple male sexually selected traits [PDF]
, 2004 Stabilizing selection has been predicted to change genetic variances and covariances so that the orientation of the genetic variance-covariance matrix (G) becomes aligned with the orientation of the fitness surface, but it is less clear how directional ...
Blows, Mark W. +2 more
core +1 more source
Use of herpes virus amplicon vectors to study brain disorders
BioTechniques, 2005 There is an enormous initiative to establish the genetic basis for disorders of brain function. Unfortunately, genetic intervention is not accomplished easily in the nervous system.
Rachael L. Neve +3 more
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Pleiotropy of FRIGIDA enhances the potential for multivariate adaptation. [PDF]
, 2013 An evolutionary response to selection requires genetic variation; however, even if it exists, then the genetic details of the variation can constrain adaptation.
Easlon, Hsien M +9 more
core +1 more source
Genetic modification of baculovirus expression vectors
Virologica Sinica, 2012 As a protein expression vector, the baculovirus demonstrates many advantages over other vectors. With the development of biotechnology, baculoviral vectors have been genetically modified to facilitate high level expression of heterologous proteins in both insect and mammalian cells.
Shu-fen, Li +3 more
openaire +3 more sources
Parasites & Vectors, 2014 BackgroundIn France as elsewhere in Europe the most prevalent TBD in humans is Lyme borreliosis, caused by different bacterial species belonging to Borrelia burgdorferi sensu lato complex and transmitted by the most important tick species in France ...
J. Cosson +11 more
semanticscholar +1 more source
Journal of Biomedical Science, 2022 Viruses are naturally endowed with the capacity to transfer genetic material between cells. Following early skepticism, engineered viruses have been used to transfer genetic information into thousands of patients, and genetic therapies are currently ...
Jonas Holst Wolff, Jacob Giehm Mikkelsen
doaj +1 more source