Results 41 to 50 of about 123,260 (289)

PhysicsGP: A Genetic Programming Approach to Event Selection [PDF]

, 2004
We present a novel multivariate classification technique based on Genetic Programming. The technique is distinct from Genetic Algorithms and offers several advantages compared to Neural Networks and Support Vector Machines. The technique optimizes a set of human-readable classifiers with respect to some user-defined performance measure.
arxiv   +1 more source

Visualizing genetic constraints [PDF]

Annals of Applied Statistics 2013, Vol. 7, No. 2, 860-882, 2013
Principal Components Analysis (PCA) is a common way to study the sources of variation in a high-dimensional data set. Typically, the leading principal components are used to understand the variation in the data or to reduce the dimension of the data for subsequent analysis. The remaining principal components are ignored since they explain little of the
arxiv   +1 more source

Designing and Construction of a Cloning Vector Encoding mtb32C and mpt51 Fragments of Mycobacterium Tuberculosis as a DNA Vaccine Candidate [PDF]

Iranian Journal of Pathology, 2018
Background & objective:  Tuberculosis (TB) remains a major cause of death around the world. Bacillus Calmette Guérin (BCG) is the only vaccine used in TB prevention that has a protective effect in children, but its effectiveness declines in adults ...
Faria Hasanzadeh Haghighi, Ehsan Aryan, Mohammad Derakhshan, Aida Gholoobi, Zahra Meshkat   +4 more
doaj  

System of centromeric, episomal, and integrative vectors based on drug resistance markers for Saccharomyces cerevisiae

BioTechniques, 2006
Integrative, centromeric, and episomal plasmids are essential for easy, fast, and reliable genetic manipulation of yeast. We constructed a system of shuttle vectors based on the widely used plasmids of the pRS series.
Christof Taxis, Michael Knop
doaj   +1 more source

Diphthamide synthesis is linked to the eEF2‐client chaperone machinery

FEBS Letters, EarlyView.
The diphthamide modification of eukaryotic translation elongation factor 2 (eEF2) is important for accurate protein synthesis. We addressed the potential coordination of de novo eEF2 synthesis with simultaneous or subsequent diphthamide modification. Our work reveals that the co‐chaperones Hgh1 and Cpr7, which are known to support folding of nascent ...
Lars Kaduhr, Klaus Mayer, Raffael Schaffrath, Johannes Buchner, Ulrich Brinkmann   +4 more
wiley   +1 more source

Selection of a Minimal Number of Significant Porcine SNPs by an Information Gain and Genetic Algorithm Hybrid Model [PDF]

Malaysian Journal of Computer Science, SI2, 79--95 (2019), 2019
A panel of large number of common Single Nucleotide Polymorphisms (SNPs) distributed across an entire porcine genome has been widely used to represent genetic variability of pig. With the advent of SNP-array technology, a genome-wide genetic profile of a specimen can be easily observed.
arxiv   +1 more source

Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β‐carbonic anhydrase

FEBS Letters, EarlyView.
Here, we performed a functional analysis of the fungal enzymes belonging to clade D of the β‐class carbonic anhydrase family (β‐D‐CA). The β‐D‐CAs in the basidiomycete Gloeophyllum trabeum and the ascomycete Trichoderma harzianum showed very low activity in the hydration of CO2 but exhibited high activity in the hydrolysis of carbonyl sulfide (COS ...
Ryuka Iizuka, Takahiro Ogawa, Rikako Tsukida, Keiichi Noguchi, David Hibbett, Yoko Katayama, Makoto Yoshida   +6 more
wiley   +1 more source

Malaria Control with Genetically Manipulated Insect Vectors

Science, 2002
At a recent workshop, experts discussed the benefits, risks, and research priorities associated with using genetically manipulated insects in the control of vector-borne diseases.
Alphey L., Beard C., Billingsley P., Coetzee M., CRISANTI, Andrea, Curtis C., Eggleston P., Godfray C., Hemingway J., Jacobs Lorena M., James A., Kafatos F., Mukwaya L., Paton M., Powell J., Schneider W., Scott T., Sina B., Sinkins S., Spielman A., Toure Y., Collins F., Sinden R.   +22 more
openaire   +5 more sources

Assessment of Genetic Shielding for Adenovirus Vectors [PDF]

The Open Gene Therapy Journal, 2009
Development of adenovirus (Ad) vectors in the clinical context has highlighted that vector efficacy may be limited by the host humoral response due to pre-existing titers of neutralizing antibodies against the vector itself in humans. Further, multiple dosing of Ad vectors based on serotype 5 would be limited.
Hui-Chen Hsu, Myunghee Kim, Jian Chen, Imre Kovesdi, Aleksandr Krendelshchikov, David T. Curiel, Susan J. Hedley, John D. Mountz   +7 more
openaire   +2 more sources

Elucidation of interface interactions between a dehydratase domain and an acyl carrier protein in cremimycin polyketide synthase

FEBS Letters, EarlyView.
In modular polyketide synthases, the dehydratase (DH) domain catalyzes the dehydration reaction of the β‐hydroxyacyl unit attached to the cognate acyl carrier protein (ACP) domain. However, it is unclear how DH interacts with ACP during the reaction. In this study, we identified DH–ACP interface residues, providing the first detailed insights into DH ...
Kaede Kotagiri, Haruka Tachibana, Daisuke Kawasaki, Taichi Chisuga, Toma Kashima, Shinya Fushinobu, Fumitaka Kudo, Tadashi Eguchi, Akimasa Miyanaga   +8 more
wiley   +1 more source