Results 21 to 30 of about 317,910 (262)
Targeted therapy in age-related macular degeneration (AMD)
Journal of Education, Health and Sport, 2020 Introduction and purpose: Age-related macular degeneration (AMD) is a major cause of blindness in highly developed countries, with blindness frequency of 8.7%.
Klaudia Daria Szumna +4 more
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DNA Vaccine Construct Formation using Mycobacterium-Specific Gene Inh-A
Journal of Preventive, Diagnostic and Treatment Strategies in Medicine, 2022 BACKGROUND: Tuberculosis (TB) remains a highly contagious disease and a leading cause of death worldwide. It is caused by Mycobacterium tuberculosis and Mycobacterium bovis. TB infection is still uncontrolled because of the unavailability of an effective
Summayya Anwar +4 more
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Genetic and Chemical Capsid Modifications of Adenovirus Vectors to Modulate Vector–Host Interactions
Viruses, 2021 Adenovirus-based vectors are playing an important role as efficacious genetic vaccines to fight the current COVID-19 pandemic. Furthermore, they have an enormous potential as oncolytic vectors for virotherapy and as vectors for classic gene therapy ...
Denice Weklak +5 more
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An optimized retroviral toolbox for overexpression and genetic perturbation of primary lymphocytes
Biology Open, 2022 Genetic manipulation of primary lymphocytes is crucial for both clinical purposes and fundamental research. Despite their broad use, we encountered a paucity of data on systematic comparison and optimization of retroviral vectors, the workhorses of ...
Lieve E. H. van der Donk +7 more
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Molecular Genetic Manipulation of Vector Mosquitoes [PDF]
Cell Host & Microbe, 2008 Genetic strategies for reducing populations of vector mosquitoes or replacing them with those that are not able to transmit pathogens benefit greatly from molecular tools that allow gene manipulation and transgenesis. Mosquito genome sequences and associated EST (expressed sequence tags) databases enable large-scale investigations to provide new ...
Terenius, Olle +3 more
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Pharmaceutics, 2022 Cancer is the leading cause of death worldwide. Tumors consist of heterogeneous cell populations that have different biological properties. While conventional cancer therapy such as chemotherapy, radiotherapy, and surgery does not target cancer cells ...
Ioana Toma +4 more
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Genetic elimination of dengue vector mosquitoes [PDF]
Proceedings of the National Academy of Sciences, 2011 An approach based on mosquitoes carrying a conditional dominant lethal gene (release of insects carrying a dominant lethal, RIDL) is being developed to control the transmission of dengue viruses by vector population suppression. A transgenic strain, designated OX3604C, of the major dengue vector, Aedes aegypti , was
Megan R, Wise de Valdez +6 more
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Frontiers in Cellular and Infection Microbiology, 2021 The piRNA pathway is a specialized small RNA interference that in mosquitoes is mechanistically distant from analogous biology in the Drosophila model.
Vanessa M. Macias +5 more
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Human Vaccines & Immunotherapeutics, 2017 Background: Genetic immunization is expected to induce the expression of antigens in a native form. The encoded peptide epitopes are presented on endogenous MHC molecules, mimicking antigen presentation during a viral infection.
S. Stenler +12 more
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Biological Procedures Online, 2003 Disarmed versions of the cytotoxin ricin can deliver fused peptides into target cells leading to MHC class I-restricted antigen presentation [Smith et al. J Immunol 2002; 169:99-107].
Smith Daniel C. +3 more
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