Results 21 to 30 of about 2,681,594 (304)

Expression, Purification and Characterization of Ricin vectors used for exogenous antigen delivery into the MHC Class I presentation pathway

Biological Procedures Online, 2003
Disarmed versions of the cytotoxin ricin can deliver fused peptides into target cells leading to MHC class I-restricted antigen presentation [Smith et al. J Immunol 2002; 169:99-107].
Smith Daniel C., Marsden Catherine J., Lord J. Michael, Roberts Lynne M.   +3 more
doaj   +1 more source

Designing Lentiviral Vectors for Gene Therapy of Genetic Diseases

Viruses, 2021
Lentiviral vectors are the most frequently used tool to stably transfer and express genes in the context of gene therapy for monogenic diseases. The vast majority of clinical applications involves an ex vivo modality whereby lentiviral vectors are used ...
Valentina Poletti, Fulvio Mavilio
doaj   +1 more source

Progress in the use of adeno-associated viral vectors for gene therapy [PDF]

, 2004
The development of safe and efficient gene transfer vectors is crucial for the success of gene therapy trials. A viral vector system promising to meet these requirements is based on the apathogenic adeno-associated virus (AAV-2), a member of the ...
Markus Braun-Falco, Hallek, M., Michael Hallek, Buning, H., Braun-Falco, M., Hildegard Büning, Büning, H;Braun-Falco, M;Hallek, M, Büning, Hildegard;Braun-Falco, Markus;Hallek, Michael   +7 more
core   +1 more source

Antigen capsid-display on human adenovirus 35 via pIX fusion is a potent vaccine platform. [PDF]

PLoS ONE, 2017
Durable protection against complex pathogens is likely to require immunity that comprises both humoral and cellular responses. While heterologous prime-boost regimens based on recombinant, replication-incompetent Adenoviral vectors (AdV) and adjuvanted ...
Nadine C Salisch, Marija Vujadinovic, Esmeralda van der Helm, Dirk Spek, Lars Vorthoren, Jan Serroyen, Harmjan Kuipers, Hanneke Schuitemaker, Roland Zahn, Jerome Custers, Jort Vellinga   +10 more
doaj   +1 more source

Genome-scale multilocus microsatellite typing of Trypanosoma cruzi discrete typing unit I reveals phylogeographic structure and specific genotypes linked to human infection. [PDF]

, 2009
Trypanosoma cruzi is the most important parasitic infection in Latin America and is also genetically highly diverse, with at least six discrete typing units (DTUs) reported: Tc I, IIa, IIb, IIc, IId, and IIe.
Torrico, Faustino, Valente, Vera, Lewis, Michael D., Llewellyn Martin S., Valente Vera, Jorge Vargas, Gaunt Michael W., Valente, Sebastiao A., Carrasco, Hernan J, Yeo, Matthew, Vera Valente, Michael A Miles, Miles Michael A., Gaunt, Michael W., Hernan J Carrasco, Miles, Michael A., Gaunt, Michael W, Carrasco, Hector Jeronimo, Vargas, Jorge, Torrico Faustino, Yeo Matthew, Michael D Lewis, Carrasco, Hernan J., Diosque Patricio, Valente Sebastiao A., Matthew Yeo, Vargas Jorge, Diosque, Patricio, Patricio Diosque, Llewellyn, Martin S, Martin S Llewellyn, Sebastiao A Valente, Miles, Michael A, Faustino Torrico, Lewis, Michael D, Carrasco Hernan J., Llewellyn, Martin S., Michael W Gaunt, Valente, Sebastiao A, Lewis Michael D.   +39 more
core   +2 more sources

RNA Viral Vectors for Accelerating Plant Synthetic Biology

Frontiers in Plant Science, 2021
The tools of synthetic biology have enormous potential to help us uncover the fundamental mechanisms controlling development and metabolism in plants.
Arjun Khakhar, Daniel F. Voytas, Daniel F. Voytas, Daniel F. Voytas   +3 more
doaj   +1 more source

Lentiviral manipulation of gene expression in human adult and embryonic stem cells [PDF]

, 2006
Human stem cells could revolutionize the field of medicine by providing a diverse range of cell types for tissue replacement therapies and drug discovery.
Joanne Crossley, Crossley, J., Andrew Godfrey, Takeuchi, Y., Clements, M.O., Boshoff, C., Godfrey, A., Mark O. Clements, Sam J. Wilson, Wilson, S.J., Yasu Takeuchi, Chris Boshoff   +11 more
core   +1 more source

GoogleNews-vectors-negative300

, 2023
GoogleNews-vectors ...
Gleb Sokolov (16468863)
core   +1 more source

Transcellular targeting of fiber- and hexon-modified adenovirus vectors across the brain microvascular endothelial cells in vitro. [PDF]

PLoS ONE, 2012
In central nervous system (CNS)-directed gene therapy, efficient targeting of brain parenchyma through the vascular route is prevented by the endothelium and the epithelium of the blood-brain and the blood-cerebrospinal fluid barriers, respectively.
Johanna P Laakkonen, Tatjana Engler, Ignacio A Romero, Babette Weksler, Pierre-Olivier Couraud, Florian Kreppel, Stefan Kochanek   +6 more
doaj   +1 more source

Biosafety Evaluation of a Chimeric Adenoviral Vector in Mini-Pigs: Insights into Immune Tolerance and Gene Therapy Potential

Biomedicines
Background: The biosafety of gene therapy products remains a major challenge to their introduction into the clinic. In particular, the problem of immunogenicity of viral vectors is the focus of attention.
Andrei Izmailov, Irina Minyazeva, Vage Markosyan, Zufar Safiullov, Ilnaz Gazizov, Ilnur Salafutdinov, Maria Markelova, Ravil Garifulin, Maksim Shmarov, Denis Logunov, Rustem Islamov, Vadim Pospelov   +11 more
doaj   +1 more source