Results 21 to 30 of about 629,088 (301)

DNA Vaccine Construct Formation using Mycobacterium-Specific Gene Inh-A

Journal of Preventive, Diagnostic and Treatment Strategies in Medicine, 2022
BACKGROUND: Tuberculosis (TB) remains a highly contagious disease and a leading cause of death worldwide. It is caused by Mycobacterium tuberculosis and Mycobacterium bovis. TB infection is still uncontrolled because of the unavailability of an effective
Summayya Anwar, Javed Anver Qureshi, Mirza Imran Shahzad, Muhammad Mohsin Zaman, Aeman Jilani   +4 more
doaj   +1 more source

Genetic and Chemical Capsid Modifications of Adenovirus Vectors to Modulate Vector–Host Interactions

Viruses, 2021
Adenovirus-based vectors are playing an important role as efficacious genetic vaccines to fight the current COVID-19 pandemic. Furthermore, they have an enormous potential as oncolytic vectors for virotherapy and as vectors for classic gene therapy ...
Denice Weklak, Daniel Pembaur, Georgia Koukou, Franziska Jönsson, Claudia Hagedorn, Florian Kreppel   +5 more
doaj   +1 more source

An optimized retroviral toolbox for overexpression and genetic perturbation of primary lymphocytes

Biology Open, 2022
Genetic manipulation of primary lymphocytes is crucial for both clinical purposes and fundamental research. Despite their broad use, we encountered a paucity of data on systematic comparison and optimization of retroviral vectors, the workhorses of ...
Lieve E. H. van der Donk, Jet van der Spek, Tom van Duivenvoorde, Marieke S. ten Brink, Teunis B. H. Geijtenbeek, Coenraad P. Kuijl, Jeroen W. J. van Heijst, Louis S. Ates   +7 more
doaj   +1 more source

Molecular Genetic Manipulation of Vector Mosquitoes [PDF]

Cell Host & Microbe, 2008
Genetic strategies for reducing populations of vector mosquitoes or replacing them with those that are not able to transmit pathogens benefit greatly from molecular tools that allow gene manipulation and transgenesis. Mosquito genome sequences and associated EST (expressed sequence tags) databases enable large-scale investigations to provide new ...
Terenius, Olle, Marinotti, Osvaldo, Sieglaff, Douglas, James, Anthony A.   +3 more
openaire   +2 more sources

Prospects for transgenesis in the chick [PDF]

, 2004
Research to develop a useful method for genetic modification of the chick has been on-going since the first demonstrations in the mouse in the 1980s that genetic modification is an invaluable tool for the study of gene function. Manipulation of the chick
Bosselman, Brazolot, Carsience, Challita, D'Costa, Evans, Eyal-Giladi, Hamburger, Han, Harvey, Harvey, Hofmann, Ikawa, Isvak, Itasaki, Ivarie, Kagami, Lois, Love, Mizuarai, Mozdziak, Mozdziak, Naito, Naito, Naito, Naldini, Nieuwkoop, Niwa, Pain, Perry, Petitte, Petitte, Pfeifer, Rapp, Reynaud, Rubinson, Salter, Salter, Sang, Sherman, Speksnijder, Stern, Tajima, Thomson, Thoraval, Tiscornia, Tsunekawa, Urven, Vick, Vick, Waddington, Wentworth, Zajchowski   +52 more
core   +1 more source

A Quality by Design Approach in Pharmaceutical Development of Non-Viral Vectors with a Focus on miRNA

Pharmaceutics, 2022
Cancer is the leading cause of death worldwide. Tumors consist of heterogeneous cell populations that have different biological properties. While conventional cancer therapy such as chemotherapy, radiotherapy, and surgery does not target cancer cells ...
Ioana Toma, Alina Silvia Porfire, Lucia Ruxandra Tefas, Ioana Berindan-Neagoe, Ioan Tomuță   +4 more
doaj   +1 more source

Genetic elimination of dengue vector mosquitoes [PDF]

Proceedings of the National Academy of Sciences, 2011
An approach based on mosquitoes carrying a conditional dominant lethal gene (release of insects carrying a dominant lethal, RIDL) is being developed to control the transmission of dengue viruses by vector population suppression. A transgenic strain, designated OX3604C, of the major dengue vector, Aedes aegypti , was
Megan R, Wise de Valdez, Derric, Nimmo, John, Betz, Hong-Fei, Gong, Anthony A, James, Luke, Alphey, William C, Black   +6 more
openaire   +2 more sources

Visualizing genetic constraints [PDF]

, 2013
Principal Components Analysis (PCA) is a common way to study the sources of variation in a high-dimensional data set. Typically, the leading principal components are used to understand the variation in the data or to reduce the dimension of the data for ...
Gaydos, Travis L., Heckman, Nancy E., Kingsolver, Joel, Kirkpatrick, Mark, Marron, J. S., Schmitt, Johanna, Stinchcombe, J. R.   +6 more
core   +3 more sources

Leaning Into the Bite: The piRNA Pathway as an Exemplar for the Genetic Engineering Need in Mosquitoes

Frontiers in Cellular and Infection Microbiology, 2021
The piRNA pathway is a specialized small RNA interference that in mosquitoes is mechanistically distant from analogous biology in the Drosophila model.
Vanessa M. Macias, Umberto Palatini, Mariangela Bonizzoni, Jason L. Rasgon, Jason L. Rasgon, Jason L. Rasgon   +5 more
doaj   +1 more source

Biosafety Concerns Involving Genetically Modified Mosquitoes to Combat Malaria and Dengue in Developing Countries [PDF]

, 2011
Malaria and dengue are the most prevalent mosquito-borne infections worldwide. Because traditional vector control methods have proven to be insufficient to control mosquito populations in endemic areas, scientists are actively working in the design of ...
Gostin, Lawrence O., Ostera, Graciela R.
core   +2 more sources