Results 11 to 20 of about 2,681,594 (304)

Genetic and Chemical Capsid Modifications of Adenovirus Vectors to Modulate Vector–Host Interactions

Viruses, 2021
Adenovirus-based vectors are playing an important role as efficacious genetic vaccines to fight the current COVID-19 pandemic. Furthermore, they have an enormous potential as oncolytic vectors for virotherapy and as vectors for classic gene therapy ...
Denice Weklak, Daniel Pembaur, Georgia Koukou, Franziska Jönsson, Claudia Hagedorn, Florian Kreppel   +5 more
doaj   +1 more source

An optimized retroviral toolbox for overexpression and genetic perturbation of primary lymphocytes

Biology Open, 2022
Genetic manipulation of primary lymphocytes is crucial for both clinical purposes and fundamental research. Despite their broad use, we encountered a paucity of data on systematic comparison and optimization of retroviral vectors, the workhorses of ...
Lieve E. H. van der Donk, Jet van der Spek, Tom van Duivenvoorde, Marieke S. ten Brink, Teunis B. H. Geijtenbeek, Coenraad P. Kuijl, Jeroen W. J. van Heijst, Louis S. Ates   +7 more
doaj   +1 more source

Molecular Genetic Manipulation of Vector Mosquitoes [PDF]

Cell Host & Microbe, 2008
Genetic strategies for reducing populations of vector mosquitoes or replacing them with those that are not able to transmit pathogens benefit greatly from molecular tools that allow gene manipulation and transgenesis. Mosquito genome sequences and associated EST (expressed sequence tags) databases enable large-scale investigations to provide new ...
Terenius, Olle, Marinotti, Osvaldo, Sieglaff, Douglas, James, Anthony A.   +3 more
openaire   +2 more sources

Tropism-modification strategies for targeted gene delivery using adenoviral vectors [PDF]

, 2010
Achieving high efficiency, targeted gene delivery with adenoviral vectors is a long-standing goal in the field of clinical gene therapy. To achieve this, platform vectors must combine efficient retargeting strategies with detargeting modifications to ...
Coughlan, L., Raul Alba, Coughlan, Lynda, Mcneish, I.A., Andrew H. Baker, Iain A. McNeish, Alba, R., Lynda Coughlan, Parker, Alan L., Nicklin, Stuart A., Bradshaw, Angela C., Bradshaw, A.C., Nicklin, S., Angela C. Bradshaw, Alan L. Parker, Stuart A. Nicklin, McNeish, Iain A., Baker, Andrew H., Parker, A.L., Alba, Raul, Baker, A.   +20 more
core   +1 more source

A Quality by Design Approach in Pharmaceutical Development of Non-Viral Vectors with a Focus on miRNA

Pharmaceutics, 2022
Cancer is the leading cause of death worldwide. Tumors consist of heterogeneous cell populations that have different biological properties. While conventional cancer therapy such as chemotherapy, radiotherapy, and surgery does not target cancer cells ...
Ioana Toma, Alina Silvia Porfire, Lucia Ruxandra Tefas, Ioana Berindan-Neagoe, Ioan Tomuță   +4 more
doaj   +1 more source

Population genetic structure of Anopheles arabiensis and Anopheles gambiae in a malaria endemic region of southern Tanzania [PDF]

, 2011
<b>BACKGROUND:</b> Genetic diversity is a key factor that enables adaptation and persistence of natural populations towards environmental conditions.
Lanzaro, Gregory C, Knols, B.G.J., Bart GJ Knols, Ferguson, H.M., Lee, Y., Yoosook Lee, B G J Knols, Gregory C Lanzaro, K R Ng'habi, Heather M Ferguson, Y Lee, Lee, Yoosook, G C Lanzaro, Ng'habi, Kija R, Knols, Bart GJ, Lanzaro, G.C., H M Ferguson, Kija R Ng'habi, Ng'habi, K.R., Ferguson, Heather M   +19 more
core   +1 more source

Leaning Into the Bite: The piRNA Pathway as an Exemplar for the Genetic Engineering Need in Mosquitoes

Frontiers in Cellular and Infection Microbiology, 2021
The piRNA pathway is a specialized small RNA interference that in mosquitoes is mechanistically distant from analogous biology in the Drosophila model.
Vanessa M. Macias, Umberto Palatini, Mariangela Bonizzoni, Jason L. Rasgon, Jason L. Rasgon, Jason L. Rasgon   +5 more
doaj   +1 more source

Genetic elimination of dengue vector mosquitoes [PDF]

Proceedings of the National Academy of Sciences, 2011
An approach based on mosquitoes carrying a conditional dominant lethal gene (release of insects carrying a dominant lethal, RIDL) is being developed to control the transmission of dengue viruses by vector population suppression. A transgenic strain, designated OX3604C, of the major dengue vector, Aedes aegypti
Megan R, Wise de Valdez, Derric, Nimmo, John, Betz, Hong-Fei, Gong, Anthony A, James, Luke, Alphey, William C, Black   +6 more
openaire   +2 more sources

Immunization with HIV-1 envelope T20-encoding DNA vaccines elicits cross-clade neutralizing antibody responses

Human Vaccines & Immunotherapeutics, 2017
Background: Genetic immunization is expected to induce the expression of antigens in a native form. The encoded peptide epitopes are presented on endogenous MHC molecules, mimicking antigen presentation during a viral infection.
S. Stenler, K. E. Lundin, L. Hansen, S. Petkov, N. Mozafari, M. Isaguliants, P. Blomberg, C. I. E. Smith, D. M. Goldenberg, C.-H. Chang, K. Ljungberg, J. Hinkula, B. Wahren   +12 more
doaj   +1 more source

Prospects for transgenesis in the chick [PDF]

, 2004
Research to develop a useful method for genetic modification of the chick has been on-going since the first demonstrations in the mouse in the 1980s that genetic modification is an invaluable tool for the study of gene function. Manipulation of the chick
Sang, Helen
core   +1 more source