Results 31 to 40 of about 629,088 (301)
Human Vaccines & Immunotherapeutics, 2017 Background: Genetic immunization is expected to induce the expression of antigens in a native form. The encoded peptide epitopes are presented on endogenous MHC molecules, mimicking antigen presentation during a viral infection.
S. Stenler +12 more
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CD20 and CD19 targeted vectors induce minimal activation of resting B lymphocytes [PDF]
, 2013 B lymphocytes are an important cell population of the immune system. However, until recently it was not possible to transduce resting B lymphocytes with retro- or lentiviral vectors, making them unsusceptible for genetic manipulations by these vectors ...
A Pezzutto +51 more
core +3 more sources
Biological Procedures Online, 2003 Disarmed versions of the cytotoxin ricin can deliver fused peptides into target cells leading to MHC class I-restricted antigen presentation [Smith et al. J Immunol 2002; 169:99-107].
Smith Daniel C. +3 more
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In vivo genetic manipulation of inner ear connexin expression by bovine adeno-Associated viral vectors [PDF]
, 2017 We have previously shown that in vitro transduction with bovine adeno-associated viral (BAAV) vectors restores connexin expression and rescues gap junction coupling in cochlear organotypic cultures from connexin-deficient mice that are models DFNB1 ...
Campioni, Matteo +7 more
core +1 more source
Sparse reduced-rank regression for imaging genetics studies: models and applications [PDF]
, 2012 We present a novel statistical technique; the sparse reduced rank regression (sRRR) model which is a strategy for multivariate modelling of high-dimensional imaging responses and genetic predictors.
Vounou, Maria, Vounou, Maria
core +1 more source
Antigen capsid-display on human adenovirus 35 via pIX fusion is a potent vaccine platform. [PDF]
PLoS ONE, 2017 Durable protection against complex pathogens is likely to require immunity that comprises both humoral and cellular responses. While heterologous prime-boost regimens based on recombinant, replication-incompetent Adenoviral vectors (AdV) and adjuvanted ...
Nadine C Salisch +10 more
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Designing Lentiviral Vectors for Gene Therapy of Genetic Diseases
Viruses, 2021 Lentiviral vectors are the most frequently used tool to stably transfer and express genes in the context of gene therapy for monogenic diseases. The vast majority of clinical applications involves an ex vivo modality whereby lentiviral vectors are used ...
Valentina Poletti, Fulvio Mavilio
doaj +1 more source
RNA Viral Vectors for Accelerating Plant Synthetic Biology
Frontiers in Plant Science, 2021 The tools of synthetic biology have enormous potential to help us uncover the fundamental mechanisms controlling development and metabolism in plants.
Arjun Khakhar +3 more
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Anticipating the species jump: surveillance for emerging viral threats. [PDF]
, 2012 Zoonotic disease surveillance is typically triggered after animal pathogens have already infected humans. Are there ways to identify high-risk viruses before they emerge in humans? If so, then how and where can identifications be made and by what methods?
Bush, RM +5 more
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Transcellular targeting of fiber- and hexon-modified adenovirus vectors across the brain microvascular endothelial cells in vitro. [PDF]
PLoS ONE, 2012 In central nervous system (CNS)-directed gene therapy, efficient targeting of brain parenchyma through the vascular route is prevented by the endothelium and the epithelium of the blood-brain and the blood-cerebrospinal fluid barriers, respectively.
Johanna P Laakkonen +6 more
doaj +1 more source