Results 31 to 40 of about 317,910 (262)

Antigen capsid-display on human adenovirus 35 via pIX fusion is a potent vaccine platform. [PDF]

PLoS ONE, 2017
Durable protection against complex pathogens is likely to require immunity that comprises both humoral and cellular responses. While heterologous prime-boost regimens based on recombinant, replication-incompetent Adenoviral vectors (AdV) and adjuvanted ...
Nadine C Salisch, Marija Vujadinovic, Esmeralda van der Helm, Dirk Spek, Lars Vorthoren, Jan Serroyen, Harmjan Kuipers, Hanneke Schuitemaker, Roland Zahn, Jerome Custers, Jort Vellinga   +10 more
doaj   +1 more source

RNA Viral Vectors for Accelerating Plant Synthetic Biology

Frontiers in Plant Science, 2021
The tools of synthetic biology have enormous potential to help us uncover the fundamental mechanisms controlling development and metabolism in plants.
Arjun Khakhar, Daniel F. Voytas, Daniel F. Voytas, Daniel F. Voytas   +3 more
doaj   +1 more source

Transcellular targeting of fiber- and hexon-modified adenovirus vectors across the brain microvascular endothelial cells in vitro. [PDF]

PLoS ONE, 2012
In central nervous system (CNS)-directed gene therapy, efficient targeting of brain parenchyma through the vascular route is prevented by the endothelium and the epithelium of the blood-brain and the blood-cerebrospinal fluid barriers, respectively.
Johanna P Laakkonen, Tatjana Engler, Ignacio A Romero, Babette Weksler, Pierre-Olivier Couraud, Florian Kreppel, Stefan Kochanek   +6 more
doaj   +1 more source

Biosafety Evaluation of a Chimeric Adenoviral Vector in Mini-Pigs: Insights into Immune Tolerance and Gene Therapy Potential

Biomedicines
Background: The biosafety of gene therapy products remains a major challenge to their introduction into the clinic. In particular, the problem of immunogenicity of viral vectors is the focus of attention.
Andrei Izmailov, Irina Minyazeva, Vage Markosyan, Zufar Safiullov, Ilnaz Gazizov, Ilnur Salafutdinov, Maria Markelova, Ravil Garifulin, Maksim Shmarov, Denis Logunov, Rustem Islamov, Vadim Pospelov   +11 more
doaj   +1 more source

Beyond Gene Delivery: Strategies to Engineer the Surfaces of Viral Vectors

Biomedicines, 2013
Viral vectors have been extensively studied due to their great transduction efficiency compared to non-viral vectors. These vectors have been used extensively in gene therapy, enabling the comprehension of, not only the advantages of these vectors, but ...
Cristian Capasso, Mari Hirvinen, Vincenzo Cerullo   +2 more
doaj   +1 more source

Use of herpes virus amplicon vectors to study brain disorders

BioTechniques, 2005
There is an enormous initiative to establish the genetic basis for disorders of brain function. Unfortunately, genetic intervention is not accomplished easily in the nervous system.
Rachael L. Neve, Kim A. Neve, Eric J. Nestler, William A. Carlezon   +3 more
doaj   +1 more source

Colony polymerase chain reaction of stably transfected Trypanosoma cruzi grown on solid medium [PDF]

Memorias do Instituto Oswaldo Cruz, 2000
Tools for the genetic manipulation of Trypanosoma cruzi are largely unavailable, although several vectors for transfection of epimastigotes and expression of foreign or recombinant genes have been developed. We have previously constructed several plasmid
Wagner G dos Santos, Ivelina Metcheva, Gregory A Buck   +2 more
doaj   +1 more source

Genetic Variation in Insect Vectors: Death of Typology?

Insects, 2018
The issue of typological versus population thinking in biology is briefly introduced and defined. It is then emphasized how population thinking is most relevant and useful in vector biology.
Jeffrey R. Powell
doaj   +1 more source

Delivering genes with human immunodeficiency virus-derived vehicles: still state-of-the-art after 25 years

Journal of Biomedical Science, 2022
Viruses are naturally endowed with the capacity to transfer genetic material between cells. Following early skepticism, engineered viruses have been used to transfer genetic information into thousands of patients, and genetic therapies are currently ...
Jonas Holst Wolff, Jacob Giehm Mikkelsen
doaj   +1 more source

Genetic Manipulation of Ticks: A Paradigm Shift in Tick and Tick-Borne Diseases Research

Frontiers in Cellular and Infection Microbiology, 2021
Ticks are obligate hematophagous arthropods that are distributed worldwide and are one of the most important vectors of pathogens affecting humans and animals.
Andrew Nuss, Andrew Nuss, Arvind Sharma, Monika Gulia-Nuss   +3 more
doaj   +1 more source