Results 51 to 60 of about 4,784,986 (369)
Genetic Manipulation of Ticks: A Paradigm Shift in Tick and Tick-Borne Diseases Research
Frontiers in Cellular and Infection Microbiology, 2021 Ticks are obligate hematophagous arthropods that are distributed worldwide and are one of the most important vectors of pathogens affecting humans and animals.
Andrew Nuss +3 more
doaj +1 more source
The genetic basis of host preference and resting behavior in the major African malaria vector, Anopheles arabiensis [PDF]
, 2016 Malaria transmission is dependent on the propensity of Anopheles mosquitoes to bite humans (anthropophily) instead of other dead end hosts. Recent increases in the usage of Long Lasting Insecticide Treated Nets (LLINs) in Africa have been associated ...
Collier, T. J. +12 more
core +3 more sources
Geminiviruses and their application in biotechnology
Journal of Integrative Agriculture, 2017 Being a major class of single-stranded DNA viruses, geminiviruses are mostly studied due to their catastrophic infectious effect on crops. These DNA viruses are characteristic for their ability in quickly multiplying viral genetic materials without ...
Qiu-ying YANG, Bo DING, Xue-ping ZHOU
doaj +1 more source
Simulating population genetics of pathogen vectors in changing landscapes: guidelines and application with Triatoma brasiliensis. [PDF]
PLoS Neglected Tropical Diseases, 2014 BACKGROUND:Understanding the mechanisms that influence the population dynamics and spatial genetic structure of the vectors of pathogens infecting humans is a central issue in tropical epidemiology.
Francois Rebaudo +5 more
doaj +1 more source
De novo formed satellite DNA-based mammalian artificial chromosomes and their possible applications. [PDF]
, 2015 Mammalian artificial chromosomes (MACs) are non-integrating, autonomously replicating natural chromosome-based vectors that may carry a vast amount of genetic material, which in turn enable potentially prolonged, safe, and regulated therapeutic transgene
Katona, Róbert László
core +1 more source
BioTechniques, 2006 Integrative, centromeric, and episomal plasmids are essential for easy, fast, and reliable genetic manipulation of yeast. We constructed a system of shuttle vectors based on the widely used plasmids of the pRS series.
Christof Taxis, Michael Knop
doaj +1 more source
Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
FEBS Letters, EarlyView.This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source
FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
mBio, 2020 Red blood cell (RBC) invasion by Plasmodium merozoites requires multiple steps that are regulated by signaling pathways. Exposure of P. falciparum merozoites to the physiological signal of low K+, as found in blood plasma, leads to a rise in cytosolic ...
Kunal R. More +13 more
doaj +1 more source
Natural selection and genetic variation in a promising Chagas disease drug target: Trypanosoma cruzi trans-sialidase [PDF]
, 2017 Rational drug design is a powerful method in which new and innovative therapeutics can be designed based on knowledge of the biological target aiming to provide more efficacious and responsible therapeutics.
Gallant, Joseph P.
core +1 more source