Results 11 to 20 of about 3,096,858 (303)

sgRNA Knock-in Mouse Provides an Alternative Approach for In Vivo Genetic Modification

Frontiers in Cell and Developmental Biology, 2022
Functional genomics in a mammalian model such as mice is fundamental for understanding human biology. The CRISPR/Cas9 system dramatically changed the tempo of obtaining genetic mouse models due to high efficiency.
Lichen Zhang, Lichen Zhang, Wushan Li, Wushan Li, Zhuangzhuang Liu, Zhuangzhuang Liu, Yang Liu, Yang Liu, Zhilong Liu, Zhilong Liu, Yanrong Gu, Yanrong Gu, Le He, Le He, Binhui Zhou, Binhui Zhou, Tianhan Li, Tianhan Li, Tianzhu Chao, Tianzhu Chao, Yinming Liang, Yinming Liang, Yinming Liang, Liaoxun Lu, Liaoxun Lu, Liaoxun Lu   +25 more
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Cutaneous melanoma in genetically modified animals [PDF]

Pigment Cell Research, 2007
AbstractCutaneous melanomas are tumors originating from skin melanocytes which are present in hair follicles, and interfollicular epidermal and dermal layers. Experimental work in model systems involves in silico, in vitro and in vivo analyses. Such models allow to mimick melanocytic aberrations characteristic of melanoma, and to potentially exploit ...
Larue, L., Beermann, F.
openaire   +2 more sources

Use of rodents as models of human diseases

Journal of Pharmacy and Bioallied Sciences, 2014
Advances in molecular biology have significantly increased the understanding of the biology of different diseases. However, these discoveries have not yet been fully translated into improved treatments for patients with diseases such as cancers.
Thierry F Vandamme
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Effects of Genetically Modified Food on Gut Microbiota in Animal Models: A Systematic Review [PDF]

Journal of Health Sciences and Surveillance System
Background: There are some debates about the possible unintended effects of genetically modified (GM) crops on consumer health. The gut microbiota plays an important role in maintaining the health of the host, especially in gastrointestinal diseases. The
Maryam Nejabat, Mohammadreza Heydari, Parisa Keshani, Hassan Joulaei, Nazanin Nazari   +4 more
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Modern approaches to production of safe and effective genetically modified rabies vaccines for animals

Ветеринария сегодня, 2023
Rabies is a dangerous zoonoticdisease that affects the central nervous system, causes encephalomyelitis and paralyses and Is almost invariably fatal.
M. I. Doronin, A. Mazloum, D. V. Mikhalishin, M. N. Mitrofanova, A. Yu. Sukharkov, V. V. Kiseleva, A. V. Sprygin   +6 more
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Factors Affecting the Adoption of Genetically Modified Animals in the Food and Pharmaceutical Chains

Bio-based and Applied Economics, 2012
The production of genetically modified (GM) animals is an emerging technique that could potentially impact the livestock and pharmaceutical industries.
Cristina Mora, Davide Menozzi, Gijs Kleter, Lusine H. Aramyan, Natasha I. Valeeva, Karin l. Zimmermann, Giddalury Pakki Reddy   +6 more
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INFLUENCE OF ARGENTUM NANOPARTICLES ON ECONOMIC AND PHYSIOLOGICAL-BIOCHEMICAL INDICATORS OF LACTATING COWS DURING LONG FEEDING WITH TRADITIONAL AND TRANSGENIC SOYBEAN

Тваринництво та технології харчових продуктів, 2020
Ukraine is among the world’s top ten soybean-producing countries. The significant prevalence of Roundup transgenic soybean varieties increases the likelihood of it becoming part of farm animal feed.
N. M. Omelchenko
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Breeding and Maintenance of Immunodeficient Mouse Lines under SPF Conditions—A Call for Individualized Severity Analyses and Approval Procedures

Animals, 2021
In the EU, the breeding of genetically modified laboratory animals is, by definition, an animal experiment if the offspring may experience pain, suffering, or harm. In order to determine the actual burden of genetically modified mice, established methods
Thomas Kammertoens, Sarah Jeuthe, Heike Baranzke, Antonina Klippert, Christa Thöne-Reineke   +4 more
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Prevalence of genetically modified soybean in animal feedingstuffs in Poland [PDF]

Journal of Veterinary Research, 2021
Abstract Introduction Globally, genetically modified (GM) crops were grown on 191.7 million hectares in 2018, which were mostly sown with soybean, maize, cotton, oilseed rape, and rice. The most popular traits introduced through genetic modification include herbicide and pest insect resistance.
Sieradzki Zbigniew, Mazur Małgorzata, Król Beata, Kwiatek Krzysztof   +3 more
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Manipulations with early mouse embryos for generation of genetically modified animals

Вавиловский журнал генетики и селекции, 2017
Recently, genome-editing technologies have  become more efficient and accessible. The discovery of nucleases for directional genome editing (CRISPR/Cas9, TALEN, ZFNs) significantly accelerated and simplified the production of mice with targeted gene ...
A. N. Korablev, I. A. Serova, B. V. Skryabin   +2 more
doaj   +1 more source