Results 11 to 20 of about 172,767 (250)

Challenges in the use of nanostructures as carriers of nucleic acids in clinical practice

Einstein (São Paulo), 2022
The delivery of nucleic acids to cells is considered a crucial step for the success of genetic modifications aimed at therapeutic purposes or production of genetically modified animals.
Carolina Capobiango Romano Quintão, Luiz Sérgio de Almeida Camargo, Humberto de Mello Brandão, Naiara Zoccal Saraiva, Michele Munk   +4 more
doaj   +1 more source

Current status of the application of gene editing in pigs

The Journal of Reproduction and Development, 2021
Genetically modified animals, especially rodents, are widely used in biomedical research. However, non-rodent models are required for efficient translational medicine and preclinical studies.
Fuminori TANIHARA, Maki HIRATA, Takeshige OTOI   +2 more
doaj   +1 more source

sgRNA Knock-in Mouse Provides an Alternative Approach for In Vivo Genetic Modification

Frontiers in Cell and Developmental Biology, 2022
Functional genomics in a mammalian model such as mice is fundamental for understanding human biology. The CRISPR/Cas9 system dramatically changed the tempo of obtaining genetic mouse models due to high efficiency.
Lichen Zhang, Lichen Zhang, Wushan Li, Wushan Li, Zhuangzhuang Liu, Zhuangzhuang Liu, Yang Liu, Yang Liu, Zhilong Liu, Zhilong Liu, Yanrong Gu, Yanrong Gu, Le He, Le He, Binhui Zhou, Binhui Zhou, Tianhan Li, Tianhan Li, Tianzhu Chao, Tianzhu Chao, Yinming Liang, Yinming Liang, Yinming Liang, Liaoxun Lu, Liaoxun Lu, Liaoxun Lu   +25 more
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Cutaneous melanoma in genetically modified animals [PDF]

Pigment Cell Research, 2007
AbstractCutaneous melanomas are tumors originating from skin melanocytes which are present in hair follicles, and interfollicular epidermal and dermal layers. Experimental work in model systems involves in silico, in vitro and in vivo analyses. Such models allow to mimick melanocytic aberrations characteristic of melanoma, and to potentially exploit ...
Larue, L., Beermann, F.
openaire   +2 more sources

Use of rodents as models of human diseases

Journal of Pharmacy and Bioallied Sciences, 2014
Advances in molecular biology have significantly increased the understanding of the biology of different diseases. However, these discoveries have not yet been fully translated into improved treatments for patients with diseases such as cancers.
Thierry F Vandamme
doaj   +1 more source

Effects of Genetically Modified Food on Gut Microbiota in Animal Models: A Systematic Review [PDF]

Journal of Health Sciences and Surveillance System
Background: There are some debates about the possible unintended effects of genetically modified (GM) crops on consumer health. The gut microbiota plays an important role in maintaining the health of the host, especially in gastrointestinal diseases. The
Maryam Nejabat, Mohammadreza Heydari, Parisa Keshani, Hassan Joulaei, Nazanin Nazari   +4 more
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Modern approaches to production of safe and effective genetically modified rabies vaccines for animals

Ветеринария сегодня, 2023
Rabies is a dangerous zoonoticdisease that affects the central nervous system, causes encephalomyelitis and paralyses and Is almost invariably fatal.
M. I. Doronin, A. Mazloum, D. V. Mikhalishin, M. N. Mitrofanova, A. Yu. Sukharkov, V. V. Kiseleva, A. V. Sprygin   +6 more
doaj   +1 more source

Factors Affecting the Adoption of Genetically Modified Animals in the Food and Pharmaceutical Chains

Bio-based and Applied Economics, 2012
The production of genetically modified (GM) animals is an emerging technique that could potentially impact the livestock and pharmaceutical industries.
Cristina Mora, Davide Menozzi, Gijs Kleter, Lusine H. Aramyan, Natasha I. Valeeva, Karin l. Zimmermann, Giddalury Pakki Reddy   +6 more
doaj   +1 more source

Breeding and Maintenance of Immunodeficient Mouse Lines under SPF Conditions—A Call for Individualized Severity Analyses and Approval Procedures

Animals, 2021
In the EU, the breeding of genetically modified laboratory animals is, by definition, an animal experiment if the offspring may experience pain, suffering, or harm. In order to determine the actual burden of genetically modified mice, established methods
Thomas Kammertoens, Sarah Jeuthe, Heike Baranzke, Antonina Klippert, Christa Thöne-Reineke   +4 more
doaj   +1 more source

Welfare Issues of Genetically Modified Animals [PDF]

ILAR Journal, 2002
Genetically engineered animals have opened new frontiers in the study of physiology and disease processes. Mutant animals offer more accurate disease models and increased precision for pathogenesis and treatment studies. Their use offers hope for improved therapy to patients with conditions that currently have poor or ineffective treatments.
openaire   +2 more sources