Results 61 to 70 of about 313,603 (373)
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
Safety assessment of biotechnology used in animal production, including genetically modified (GM) feed and GM animals - a review [PDF]
, 2010 Since the beginning of the large-scale commercial cultivation of genetically modified (GM) crops in the mid-nineties, it has continuously increased.
Kleter, G.A., Kok, E.J.
core +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
A rice exocyst subunit gene SEC3A is required for anther dehiscence
Crop JournalAnther dehiscence controls optimal interaction between pollen and stigma, thereby determining the successful sexual reproduction. The regulators or mechanisms of this process remain elusive.
Ranran Tu +7 more
doaj +1 more source
Plant Co-expression Annotation Resource: a web server for identifying targets for genetically modified crop breeding pipelines [PDF]
, 2021 Marcos Viana +2 more
openalex +1 more source
GM crops & food, 2020 Evolution of resistance to genetically modified Bacillus thuringiensis (Bt) crops in pest populations is a major threat to the sustainability of the technology.
F. Huang
semanticscholar +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Different applications for genetically modified crops [PDF]
, 2005 65 pages.Congressional hearing on the various uses of biotechnology, with testimonies and prepared statements from producers in the pharmaceutical, forestry, cotton, and papaya ...
United States. Congress. House. Committee on Small Business. Subcommittee on Rural Enterprises, Agriculture, and Technology
core
Genetically modified crops, regulatory delays, and international trade
, 2017 Genetically modified (GM) crops have been produced in the initial adopting countries for 20 years. Over this period of time, hundreds of articles and reports have been published by academic journals, government regulatory agencies, and national science ...
S. Smyth
semanticscholar +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source