Results 61 to 70 of about 54,452 (291)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Development of genetically modified maize MIR604 matrix reference materials [PDF]
Acta Agronomica Sinica, 2020 The safety supervision of genetically modified organisms (GMO) is the guarantee for the healthy development of the biotechnology, and the reference materials (RM) are the material basis for GMOs detection. The lack of RMs makes it difficult to ensure the accuracy, reliability and comparability of the test data. GM maize MIR604 is approved for import as
Shan-Shan ZHAI +10 more
openaire +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Plant, Soil and Environment, 2017 Cytoplasmic male sterility (CMS) allows efficient biological confinement of transgenes if pollen-mediated gene flow has to be reduced or eliminated. For introduction of CMS maize in agricultural practice, sufficient yields comparable with conventional ...
Heidrun BÜCKMANN +12 more
doaj +1 more source
Biotechnology, environmental forcing, and unintended trophic cascades [PDF]
, 2009 A long ongoing discussion between scientists and policy decision-makers seems to have entered recently into a new phase. The consequences of release of transgenic crops into the environment are being discussed not only by scientists but also by farmers ...
Lotz, L.A.P., Mulder, C.
core +2 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Development of molecular biology techniques for the detection of genetically modified organisms in maize food products [PDF]
, 2008 In the last years, the increase in the cultivated area of genetically modified (GM) maize has become a reality. GA21, MON810 and MON 863 maize crops are some of the authorized maize events for food and feed under the European Union (EU) regulations ...
Amaral, Joana S. +4 more
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source