Results 241 to 250 of about 505,318 (323)

An Animal‐Free Patient‐Derived Tissue‐Mimetic Biochip Model of the Human Synovial Membrane for Human‐Relevant Osteoarthritis Research

Advanced Healthcare Materials, EarlyView.
Reihs et al. present the development of a humanized, animal‐free synovial membrane model for osteoarthritis. Methods include 3D biochip cultures of human‐primary OA synoviocytes with matrix and serum surrogates. Results show replication of synovial architecture and increased Yap1 expression.
Eva I. Reihs, Alexander Stoegner, Mateo G. Vasconez Martínez, Markus M. Schreiner, Melanie Cezanne, Ruth Gruebl‐Barabas, Bettina Rodriguez‐Molina, Juergen Alphonsus, Silvia Hayer, Richard Lass, Iris Gerner, Florien Jenner, Wolfgang Holnthoner, Stefan Toegel, Peter Ertl, Hans P. Kiener, Reinhard Windhager, Mario Rothbauer   +17 more
wiley   +1 more source

Genetic Animal Models of Cardiovascular Pathologies. [PDF]

Biomedicines
Blagonravov M, Ryabinina A, Karpov R, Ovechkina V, Filatov M, Silaeva Y, Syatkin S, Agostinelli E, Belousov V, Mozhaev A.   +9 more
europepmc   +1 more source

Microphysiological Systems for Comorbidity Studies: Chronic Kidney Disease and Osteoarthritis

Advanced Healthcare Materials, EarlyView.
This review highlights the potential of organ‐on‐a‐chip systems for studying comorbidities, using chronic kidney disease (CKD) and osteoarthritis (OA) as examples. It summarizes recent advances in kidney‐on‐a‐chip and joint‐on‐a‐chip models and discusses their current and potential application in investigating CKD, OA, and CKD‐OA comorbidity, aiming to
Mingying Han, Weiping Lin, Yuanxiong Cao, Patricia Murray, Bettina Wilm, Stephen J McWilliam, Jude Curran, Ruoxiao Xie   +7 more
wiley   +1 more source

CRISPR-Cas9 in the Tailoring of Genetically Engineered Animals. [PDF]

Curr Issues Mol Biol
Urban W, Kropacz M, Łach M, Jankowska A.   +3 more
europepmc   +1 more source

Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo

Advanced Healthcare Materials, EarlyView.
This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla, Vincenzo Verdi, Willemijn de Voogt, Mariona Estapé Sentí, Arnold C. Koekman, Julian Rietveld, Sven van Kempen, Qiangbing Yang, Juliette van Merris, Guido Jenster, Martin E. van Royen, Marcel H. Fens, Sander A. A. Kooijmans, Wytske M. van Weerden, Guillaume van Niel, Pieter Vader, Raymond M. Schiffelers   +16 more
wiley   +1 more source

Human Neural Stem Cells Genetically Modified to Overexpress Akt1 Provide Neuroprotection and Functional Improvement in Mouse Stroke Model

, 2009
Hong J. Lee, Mi K. Kim, Hee J. Kim, Seung Up Kim   +3 more
openalex   +2 more sources

Immunomodulation With Local, Sustained Delivery of Pituitary Adenylate Cyclase Activating Polypeptide Results in Improved Functional Recovery in Stroke‐Injured Mice

Advanced Healthcare Materials, EarlyView.
The tissue and functional benefits are demonstrated with local, sustained delivery of an anti‐inflammatory peptide, pituitary adenylate cyclase‐activating polypeptide (PACAP), for stroke treatment in a mouse model. Prolonged PACAP treatment modulated astrocyte and microglia toward pro‐reparative phenotypes, enhanced neuroprotection and preservation of ...
Eric Ho, David Xinzheyang Li, Hong Cui, Dania Akbar, Ricky Siu, Cindi M. Morshead, David Chatenet, Molly S. Shoichet   +7 more
wiley   +1 more source

Of Mice and Molecules: Research with Genetically Modified Mouse Models

Environmental Health Perspectives, 2005
openaire   +2 more sources

Gene Therapies in Dermatological Diseases: A Breakthrough in Treatment. [PDF]

Int J Mol Sci
Lisińska W, Cegiełka P, Zalewska Z, Bien N, Sobolewska-Sztychny D, Narbutt J, Lesiak A.   +6 more
europepmc   +1 more source

Conserving, Distributing and Managing Genetically Modified Mouse Lines by Sperm Cryopreservation

, 2011
G. Charles Ostermeier, Michael V. Wiles, Jane Farley, Robert A. Taft   +3 more
openalex   +2 more sources