Results 301 to 310 of about 505,318 (323)

Genetic modifiers that aggravate the neurological phenotype of the wobbler mouse

Neuroreport, 2002
The autosomal recessive mutation wobbler of the mouse (phenotype WR; genotype wr/wr) causes muscular atrophy due to motoneuron degeneration with 100% penetrance on the standard Mus musculus laboratorius C57BL/6J background. In inter- and backcrosses with M. m.
Ulbrich, Michael, Schmidt, Volker, Ronsiek, Melanie, Mussmann, Anke, Bartsch, Jörg, Augustin, Martin, Jockusch, Harald, Schmitt-John, Thomas   +7 more
openaire   +4 more sources

Mouse Sperm Cryopreservation and Recovery of Genetically Modified Mice [PDF]

, 2016
Highly definable genetically, the humble mouse is the "reagent" mammal of choice with which to probe and begin to understand the human condition in all its complexities. With the recent advance in direct genome editing via targeted nucleases, e.g., TALEN and CRISPR/Cas9, the possibilities in using these sophisticated tools have increased substantially ...
Low, Benjamin E, Taft, Robert A, Wiles, Michael V   +2 more
openaire   +2 more sources

Genetic and Environmental Modifiers of Alzheimers Disease Phenotypes in the Mouse

Current Alzheimer Research, 2006
As a group, strains of laboratory mice carrying Alzheimer's disease (AD)-related transgenes are currently the most widely studied animal models of AD. Many AD mouse models carrying the same or similar transgene constructs demonstrate strikingly different phenotypic responses to transgene expression, mimicking the apparent genetic complexity of AD ...
Bruce T. Lamb, Davis Ryman
openaire   +3 more sources

Genetically modified mouse models for oral drug absorption and disposition

Current Opinion in Pharmacology, 2013
Intestinal absorption is an essential step in the therapeutic use of most orally administered drugs and often mediated by enterocyte transmembrane transporters. Here we discuss several of these drug transport systems and knockout mouse models to study them.
Jeroen J M A Hendrikx, Jos H. Beijnen, Jos H. Beijnen, Alfred H. Schinkel, Seng Chuan Tang   +4 more
openaire   +4 more sources

In Vivo Transplantation of Genetically Modified Mouse Embryonic Epidermis

2009
Situations in which epidermal mutant mice display early lethality after birth are rather frequent. This condition precludes any kind of analysis of adult or even newborn mice tissues. We propose the in vivo embryonic skin transplantation as an alternative to solve this problem.
Ana Belén Martínez-Cruz, Cristina Saiz, Clotilde Costa, Jesús M. Paramio, Mirentxu Santos   +4 more
openaire   +3 more sources

Genetic modifiers in mice: the example of the fragile X mouse model

Cytogenetic and Genome Research, 2004
Modifiers play an important role in most, if not all human diseases, and mouse models. For some disease models, such as the cystic fibrosis knockout mouse model, the effect of genetic factors other than the causative mutation has been well established and a modifier gene has been mapped. For other mouse models, including those of the fragile X syndrome,
Errijgers, V., Kooy, Frank
openaire   +3 more sources

Mouse Models and Genetic Modifiers in X-Linked Adrenoleukodystrophy

2003
X-linked adrenoleukodystrophy (X-ALD) is a peroxisomal disorder that affects 1 in 35000 males and is marked by neurodegeneration, adrenal insufficiency and infertility. All characteristics are not always present in every X-ALD patient and the rate of progression varies.
Ann K. Heinzer, Kirby D. Smith, Kirby D. Smith, He-Ming Wei, Jyh Feng Lu, Martina C. McGuinness, Mark Van Der Vlies, O. Colin Stine, Gaoxiang Dong, James M. Powers, Paul A. Watkins   +10 more
openaire   +3 more sources

Genetically Modified Mouse Health Reporting: A Need for Global Standardization

Lab Animal, 2003
The distribution of GM mice between facilities has raised new problems because of variable microbiological quality. One of the most important management issues concerns the methods of reporting laboratory animal health surveillance results. The authors evaluated the format and content of 380 health reports of mice received from 55 institutions in ...
Ernesto de la Cueva, Juan Martín-Caballero, Angel Naranjo   +2 more
openaire   +3 more sources

Minimizing strain influences in a genetically modified mouse phenotyping platform

Annals of the New York Academy of Sciences, 2011
Our approach has been to power studies to allow for detection of at least modest changes from a wild‐type littermate control, include assays with overlapping physiological systems to provide cross‐functional interpretive value, and to employ challenge assays.
Michael D. Hayward, David S. Grass, Olesia Buiakova   +2 more
openaire   +3 more sources

Genetically modified mouse models to investigate thyroid development, function and growth

Best Practice & Research Clinical Endocrinology & Metabolism, 2018
The thyroid gland produces thyroid hormones (TH), which are essential regulators for growth, development and metabolism. The thyroid is mainly controlled by the thyroid-stimulating hormone (TSH) that binds to its receptor (TSHR) on thyrocytes and mediates its action via different G protein-mediated signaling pathways.
Christoffer Löf, Jukka Kero, Jukka Kero, Konrad Patyra, Andreina Kero   +4 more
openaire   +5 more sources