Results 301 to 310 of about 522,034 (344)
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Mouse Models and Genetic Modifiers in X-Linked Adrenoleukodystrophy
2003X-linked adrenoleukodystrophy (X-ALD) is a peroxisomal disorder that affects 1 in 35000 males and is marked by neurodegeneration, adrenal insufficiency and infertility. All characteristics are not always present in every X-ALD patient and the rate of progression varies.
Ann K, Heinzer +9 more
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Minimizing strain influences in a genetically modified mouse phenotyping platform
Annals of the New York Academy of Sciences, 2011Our approach has been to power studies to allow for detection of at least modest changes from a wild‐type littermate control, include assays with overlapping physiological systems to provide cross‐functional interpretive value, and to employ challenge assays.
Michael D, Hayward +2 more
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Genetically modified mouse models for oral drug absorption and disposition
Current Opinion in Pharmacology, 2013Intestinal absorption is an essential step in the therapeutic use of most orally administered drugs and often mediated by enterocyte transmembrane transporters. Here we discuss several of these drug transport systems and knockout mouse models to study them.
Tang, S.C. +3 more
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Axon regeneration after spinal cord injury: Insight from genetically modified mouse models
Restorative Neurology and Neuroscience, 2008The use of genetically modified mice to study axon regeneration after spinal cord injury has served as a useful in vivo model for both loss-of-function and gain-of-function analysis of candidate proteins.
Jae K. Lee, B. Zheng
semanticscholar +1 more source
Testing genetically modified food in mouse models
2013Mit Hilfe der Gentechnik ist es möglich gezielte Erbinformationen in Nutzpflanzen zu ändern. In der australischen CSIRO Plant Industrie wurde die genetisch veränderte Nutzpflanze (Pisum sativum) entwickelt. Wissenschaftliche Ergebnisse zeigten, dass das Protein α-Amylase-Inhibitor (AAI) vorkommend in Bohnen, Pflanzen vor schädlichen Käfern beschützt ...
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Genetic and Environmental Modifiers of Alzheimers Disease Phenotypes in the Mouse
Current Alzheimer Research, 2006As a group, strains of laboratory mice carrying Alzheimer's disease (AD)-related transgenes are currently the most widely studied animal models of AD. Many AD mouse models carrying the same or similar transgene constructs demonstrate strikingly different phenotypic responses to transgene expression, mimicking the apparent genetic complexity of AD ...
Davis, Ryman, Bruce T, Lamb
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Genetic Modifiers of Cardiac Development 22q11DS Mouse Models
The FASEB Journal, 2016Over 70% of patients with 22q11.2 Deletion Syndrome (22q11DS) have congenital heart defects. The prevalence and severity of these defects make it critical for us to strive to understand the underlying mechanism of the syndrome by elucidating the gene pathways that are involved in heart development, as their disruption may lead to ...
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Genetically modified mouse models to investigate thyroid development, function and growth
Best Practice & Research Clinical Endocrinology & Metabolism, 2018The thyroid gland produces thyroid hormones (TH), which are essential regulators for growth, development and metabolism. The thyroid is mainly controlled by the thyroid-stimulating hormone (TSH) that binds to its receptor (TSHR) on thyrocytes and mediates its action via different G protein-mediated signaling pathways.
Kero Andreina +5 more
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Genetic modifiers that aggravate the neurological phenotype of the wobbler mouse
Neuroreport, 2002The autosomal recessive mutation wobbler of the mouse (phenotype WR; genotype wr/wr) causes muscular atrophy due to motoneuron degeneration with 100% penetrance on the standard Mus musculus laboratorius C57BL/6J background. In inter- and backcrosses with M. m.
Ulbrich, Michael +7 more
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