Results 61 to 70 of about 226,675 (297)
Development of HPV16 mouse and dog models for more accurate prediction of human vaccine efficacy
Laboratory Animal Research, 2023 Background Animal models are essential to understand the physiopathology of human diseases but also to evaluate new therapies. However, for several diseases there is no appropriate animal model, which complicates the development of effective therapies ...
Emmanuelle Totain +12 more
doaj +1 more source
Is abundant A-to-I RNA editing primate-specific? [PDF]
Trends in Genetics, Vol. 21, 77-81 (2005), 2004 A-To-I RNA editing is common to all eukaryotes, associated with various neurological functions. Recently, A-to-I editing was found to occur abundantly in the human transcriptome. Here we show that the frequency of A-to-I editing in humans is at least an order of magnitude higher as that of mouse, rat, chicken or fly.
arxiv +1 more source
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Journal of Neuroinflammation, 2020 Background A growing body of studies have indicated that bone marrow mesenchymal stem cells (BMSCs) have powerful analgesic effects in animal models of bone cancer pain.
Chao Zhu +9 more
doaj +1 more source
Are mouse and cat the missing link in the COVID-19 outbreaks in seafood markets? [PDF]
arXiv, 2020 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus caused the novel coronavirus disease-2019 (COVID-19) affecting the whole world. Like SARS-CoV and MERS-CoV, SARS-CoV-2 are thought to originate in bats and then spread to humans through intermediate hosts.
arxiv
Is there any sense in antisense editing? [PDF]
Trends in Genetics 21, 544-7 (2005), 2005 A number of recent studies have hypothesized that sense-antisense RNA transcript pairs create dsRNA duplexes that undergo extensive A-to-I RNA editing. Here we studied human and mouse genomic antisense regions, and found that the editing level in these areas is negligible.
arxiv +1 more source
Unraveling Genetic Modifiers in the Gria4 Mouse Model of Absence Epilepsy
PLoS Genetics, 2014 Absence epilepsy (AE) is a common type of genetic generalized epilepsy (GGE), particularly in children. AE and GGE are complex genetic diseases with few causal variants identified to date. Gria4 deficient mice provide a model of AE, one for which the common laboratory inbred strain C3H/HeJ (HeJ) harbors a natural IAP retrotransposon insertion in Gria4 ...
Frankel, Wayne N +4 more
openaire +6 more sources
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
In vivo Tumor Growth and Spontaneous Metastasis Assays Using A549 Lung Cancer Cells
Bio-Protocol, 2020 Metastasis accounts for the majority of cancer related deaths. The genetically engineered mouse (GEM) models and cell line-based subcutaneous and orthotopic mouse xenografts have been developed to study the metastatic process.
Lei Qi +6 more
doaj +1 more source
Causes and Consequences of genetic background effects illuminated by integrative genomic analysis [PDF]
Genetics 2014 196(4):1321-1336, 2013 The phenotypic consequences of individual mutations are modulated by the wild type genetic background in which they occur.Although such background dependence is widely observed, we do not know whether general patterns across species and traits exist, nor about the mechanisms underlying it.
arxiv +1 more source