Results 51 to 60 of about 279,987 (320)

Prospects for transgenesis in the chick [PDF]

, 2004
Research to develop a useful method for genetic modification of the chick has been on-going since the first demonstrations in the mouse in the 1980s that genetic modification is an invaluable tool for the study of gene function. Manipulation of the chick
Bosselman, Brazolot, Carsience, Challita, D'Costa, Evans, Eyal-Giladi, Hamburger, Han, Harvey, Harvey, Hofmann, Ikawa, Isvak, Itasaki, Ivarie, Kagami, Lois, Love, Mizuarai, Mozdziak, Mozdziak, Naito, Naito, Naito, Naldini, Nieuwkoop, Niwa, Pain, Perry, Petitte, Petitte, Pfeifer, Rapp, Reynaud, Rubinson, Salter, Salter, Sang, Sherman, Speksnijder, Stern, Tajima, Thomson, Thoraval, Tiscornia, Tsunekawa, Urven, Vick, Vick, Waddington, Wentworth, Zajchowski   +52 more
core   +1 more source

Genetic‐Genomic Replication to Identify Candidate Mouse Atherosclerosis Modifier Genes [PDF]

Journal of the American Heart Association, 2013
Objective Genetics plays a large role in atherosclerosis susceptibility in humans and mice. We attempted to confirm previously determined mouse atherosclerosis‐associated loci and use bioinformatics and transcriptomics to create a catalog of candidate atherosclerosis modifier genes at these loci.
Hsu, Jeffrey, Smith, Jonathan D.
openaire   +2 more sources

Manipulations with early mouse embryos for generation of genetically modified animals

Вавиловский журнал генетики и селекции, 2017
Recently, genome-editing technologies have  become more efficient and accessible. The discovery of nucleases for directional genome editing (CRISPR/Cas9, TALEN, ZFNs) significantly accelerated and simplified the production of mice with targeted gene ...
A. N. Korablev, I. A. Serova, B. V. Skryabin   +2 more
doaj   +1 more source

Establishment of hKDR+/+ Humanized and Rag1-/- Gene Knockout Double Genetically Modified Mouse Model

Shiyan dongwu yu bijiao yixue, 2023
ObjectiveThrough improving the potential of vascular endothelial growth factor receptor (VEGFR)-humanized mouse model (hKDR+/+) with C57BL/6N background to allow the growth of different mouse tumor cell lines, to establish novel tumor-bearing mouse ...
LIU Susu, WU Yong, CAO Yuan, ZHAO Haoyang, ZHAI Shijie, SUN Xiaowei, LI Linli, FAN Changfa   +7 more
doaj   +1 more source

DNA fragmentation index (DFI) as a measure of sperm quality and fertility in mice. [PDF]

, 2020
Although thousands of genetically modified mouse strains have been cryopreserved by sperm freezing, the likelihood of cryorecovery success cannot be accurately predicted using conventional sperm parameters.
Li, Ming-Wen, Lloyd, KC Kent
core   +1 more source

Immunocompetent murine models for the study of glioblastoma immunotherapy. [PDF]

, 2014
Glioblastoma remains a lethal diagnosis with a 5-year survival rate of less than 10%. (NEJM 352:987-96, 2005) Although immunotherapy-based approaches are capable of inducing detectable immune responses against tumor-specific antigens, improvements in ...
Bloch, Orin, Clark, Aaron J, Fakurnejad, Shayan, Ivan, Michael E, James, Charles D, Oh, Taemin, Parsa, Andrew T, Safaee, Michael, Sayegh, Eli T, Sun, Matthew Z   +9 more
core   +2 more sources

Efficient DNA knock-in using AAV-mediated delivery with 2-cell embryo CRISPR-Cas9 electroporation

Frontiers in Genome Editing, 2023
Recent advances in CRISPR-Cas genome editing technology have been instrumental in improving the efficiency to produce genetically modified animal models.
Daniel J. Davis, James F. McNew, Hailey Maresca-Fichter, Kaiwen Chen, Bhanu P. Telugu, Elizabeth C. Bryda, Elizabeth C. Bryda   +6 more
doaj   +1 more source

Tumor-Targeting Salmonella typhimurium A1-R in Combination with Trastuzumab Eradicates HER-2-Positive Cervical Cancer Cells in Patient-Derived Mouse Models. [PDF]

, 2015
We have previously developed mouse models of HER-2-positive cervical cancer. Tumors in nude mice had histological structures similar to the original tumor and were stained by anti-HER-2 antibody in the same pattern as the patient's cancer.
Bouvet, Michael, Chishima, Takashi, Endo, Itaru, Hiroshima, Yukihiko, Hoffman, Robert M, Ichikawa, Yasushi, Maawy, Ali, Matsuyama, Ryusei, Mii, Sumiyuki, Miwa, Shinji, Momiyama, Masashi, Mori, Ryutaro, Murakami, Takashi, Tanaka, Kuniya, Uehara, Fuminari, Yamamoto, Mako, Yano, Shuya, Zhang, Nan, Zhang, Yong, Zhao, Ming   +19 more
core   +3 more sources

Genetic Modifiers of Retinal Degeneration in therd3Mouse [PDF]

Investigative Opthalmology & Visual Science, 2008
In previous studies of light-induced (LRD) and age-related (ageRD) retinal degeneration (RD) between the BALB/cByJ (BALB) and B6(Cg)-Tyr(c-2J)/J (B6a) albino mouse strains, RD-modifying quantitative trait loci (QTLs) were identified. After breeding BALB- and B6a-rd3/rd3 congenic strains and finding significant differences in RD, an F1 intercross to ...
Michael, Danciger, Diego, Ogando, Haidong, Yang, Michael T, Matthes, Nicole, Yu, Kelly, Ahern, Douglas, Yasumura, Robert W, Williams, Matthew M, Lavail   +8 more
openaire   +2 more sources

Engineered Tumor-Targeted T Cells Mediate Enhanced Anti-Tumor Efficacy Both Directly and through Activation of the Endogenous Immune System. [PDF]

, 2018
Chimeric antigen receptor (CAR) T cell therapy has proven clinically beneficial against B cell acute lymphoblastic leukemia and non-Hodgkin's lymphoma. However, suboptimal clinical outcomes have been associated with decreased expansion and persistence of
Avanzi, Mauro P, Brentjens, Renier J, Cheung, Kenneth, Daniyan, Anthony F, Li, Xinghuo, Park, Hyebin, Purdon, Terence J, Spitzer, Matthew H, van Leeuwen, Dayenne G, Wijewarnasuriya, Dinali P, Yeku, Oladapo   +10 more
core   +1 more source