Results 41 to 50 of about 279,987 (320)
Cells, 2021 In mammals, the neuroendocrine system, which includes the communication between the hypothalamus and the pituitary, plays a major role in controlling body growth and cellular metabolism. GH produced from the pituitary somatotroph is considered the master
Sarmed Al-Samerria, Sally Radovick
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Current review of genetically modified lactic acid bacteria for the prevention and treatment of colitis using murine models [PDF]
, 2015 Inflammatory Bowel Diseases (IBD) are disorders of the gastrointestinal tract characterized by recurrent inflammation that requires lifelong treatments.
Azevedo, Vasco +7 more
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DEVELOPMENT OF MURINE STEM CELLS WITH CONDITIONAL KNOCKOUT OF HUMANIZED SNCA GENE
Фармация и фармакология (Пятигорск), 2023 α-synuclein is one of the key molecular links in the pathogenesis of Parkinson’s disease. The accumulated data indicate that pathogenic mutations in the Snca gene are associated with the development of neurodegenerative brain damage, indicating the ...
E. A. Patrakhanov +8 more
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F1000Research, 2013 Background: The pore-forming subunit of the cardiac sodium channel, Nav1.5, has been previously found to be mutated in genetically determined arrhythmias. Nav1.5 associates with many proteins that regulate its function and cellular localisation. In order
Katja Reinhard +3 more
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BMC Genomics, 2022 Somatic mutations drive colorectal cancer (CRC) by disrupting gene regulatory mechanisms. Distinct combinations of mutations can result in unique changes to regulatory mechanisms leading to variability in the efficacy of therapeutics.
Jonathan W. Villanueva +8 more
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Frontiers in Bioengineering and Biotechnology, 2021 There continues to be an erroneous belief that allergens (especially food allergens) are more resistant to gastrointestinal digestion than non-allergens.
Rod A. Herman, Jason M. Roper
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Stem-cell-based gene therapy for HIV infection. [PDF]
, 2013 Despite the enormous success of combined anti-retroviral therapy, HIV infection is still a lifelong disease and continues to spread rapidly worldwide. There is a pressing need to develop a treatment that will cure HIV infection.
Kitchen, Scott, Zhen, Anjie
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Development of an ex vivo model for the study of cerebrovascular function utilizing isolated mouse olfactory artery [PDF]
, 2015 OBJECTIVE: Cerebral vessels, such as intracerebral perforating arterioles isolated from rat brain, have been widely used as an ex vivo model to study the cerebrovascular function associated with cerebrovascular disorders and the therapeutic effects of ...
Dietrich, Hans H. +3 more
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The PTEN/PI3K/AKT Pathway in vivo, cancer mouse models
Frontiers in Oncology, 2014 PTEN negatively regulates PI3K signalling by dephosphorylating PIP3 to PIP2. AKT is activated downstream of PIP3 to mediate physiologic processes. Furthermore, substantial crosstalk exists with other signalling networks at all levels of the PI3K pathway.
Amancio eCarnero +2 more
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Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence
Nature Communications, 2020 The cellular composition of recurrent tumors can provide insight into resistance to therapy and inform on second line therapies. Here, using a genetically modified mouse, the authors perform barcoding experiments of the primary tumors to allow them to ...
Andrea Walens +15 more
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