Genetic platelet depletion is superior in platelet transfusion compared to current models
Haematologica, 2020 Genetically modified mice have advanced our knowledge on platelets in hemostasis and beyond tremendously. However, mouse models harbor certain limitations, including availability of platelet specific transgenic strains, and off-target effects on other ...
Manuel Salzmann +11 more
doaj +1 more source
Molecular Therapy: Oncolytics, 2022 Malignant soft tissue tumors, particularly highly malignant leiomyosarcomas, are resistant to chemotherapy and associated with a poor prognosis. T-01, a third-generation genetically modified herpes simplex virus type 1, replicates in tumor cells alone ...
Masahiko Hatta +8 more
doaj +1 more source
Genetically Encoded Calcium Indicators: A New Tool in Renal Hypertension Research [PDF]
, 2019 Hypertension is ranked as the third cause of disability-adjusted life-years. The percentage of the population suffering from hypertension will continue to increase over the next years.
Schleifenbaum, Johanna, Zhong, Cheng
core +1 more source
Blood-testis barrier and spermatogenesis: lessons from genetically-modified mice
Asian Journal of Andrology, 2014 The blood-testis barrier (BTB) is found between adjacent Sertoli cells in the testis where it creates a unique microenvironment for the development and maturation of meiotic and postmeiotic germ cells in seminiferous tubes.
Xiao-Hua Jiang +6 more
doaj +1 more source
An open-source video tracking system for mouse locomotor activity analysis
BMC Research Notes, 2020 Objective The ability to accurately and efficiently quantify mouse locomotor activity is essential for evaluating therapeutic efficacy and phenotyping genetically modified mice, in particular for the research of neuromuscular diseases.
Chen Zhang, Haiwen Li, Renzhi Han
doaj +1 more source
Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation [PDF]
, 2006 The planar cell polarity (PCP) pathway is conserved throughout evolution, but it mediates distinct developmental processes. In Drosophila, members of the PCP pathway localize in a polarized fashion to specify the cellular polarity within the plane of the
Brinkman, Brendan C. +9 more
core +1 more source
Translational outcomes in a full gene deletion of ubiquitin protein ligase E3A rat model of Angelman syndrome. [PDF]
, 2020 Angelman syndrome (AS) is a rare neurodevelopmental disorder characterized by developmental delay, impaired communication, motor deficits and ataxia, intellectual disabilities, microcephaly, and seizures. The genetic cause of AS is the loss of expression
Adhikari, A +27 more
core +2 more sources
Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory
Nature Communications, 2018 Structural remodeling of dendritic spines is thought to be a mechanism of memory storage. Here, the authors look at how spine turnover and clustering predict future learning and memory performance, and see that a genetically modified mouse with enhanced ...
Adam C. Frank +10 more
doaj +1 more source
Cancer immunoprevention: from mice to early clinical trials
BMC Immunology, 2018 Cancer immunoprevention is based on the fact that a functioning immune system controls tumor onset and development in humans and animals, thus leading to the idea that the enhancement of immune responses in healthy individuals could effectively reduce ...
Arianna Palladini +3 more
doaj +1 more source
sgRNA Knock-in Mouse Provides an Alternative Approach for In Vivo Genetic Modification
Frontiers in Cell and Developmental Biology, 2022 Functional genomics in a mammalian model such as mice is fundamental for understanding human biology. The CRISPR/Cas9 system dramatically changed the tempo of obtaining genetic mouse models due to high efficiency.
Lichen Zhang +25 more
doaj +1 more source