Results 31 to 40 of about 279,987 (320)

Genetically modified mouse models for the study of nonalcoholic fatty liver disease. [PDF]

World J Gastroenterol, 2012
Nagarajan P, Mahesh Kumar MJ, Venkatesan R, Majundar SS, Juyal RC.   +4 more
europepmc   +3 more sources

Mouse genetics reveals Barttin as a genetic modifier of Joubert syndrome [PDF]

Proceedings of the National Academy of Sciences, 2019
Significance Our current understanding of genetic disease is often inadequate, largely due to genetic background effects that modify disease presentation. This is particularly challenging for rare diseases that lack sufficient numbers of patients for genome-wide association studies.
Ramsbottom, Simon, Thelwall, Peter, Wood, Katrina, Clowry, Gavin, Devlin, Laura, Silbermann, Flora, Spiewak, Helena, Shril, Shirlee, Molinari, Elisa, Hildebrandt, Friedhelm, Gunay-Aygun, Meral, Saunier, Sophie, Cordell, Heather, Sayer, John, Miles, Colin   +14 more
openaire   +4 more sources

The UCSF Mouse Inventory Database Application, an Open Source Web App for Sharing Mutant Mice Within a Research Community

G3: Genes, Genomes, Genetics, 2020
The UCSF Mouse Inventory Database Application is an open-source Web App that provides information about the mutant alleles, transgenes, and inbred strains maintained by investigators at the university and facilitates sharing of these resources within the
Estelle Wall, Jonathan Scoles, Adriane Joo, Ophir Klein, Carlo Quinonez, Jeffrey O. Bush, Gail R. Martin, Diana J. Laird   +7 more
doaj   +1 more source

Development of an ObLiGaRe Doxycycline Inducible Cas9 system for pre-clinical cancer drug discovery

Nature Communications, 2020
CRISPR/Cas9 technology has revolutionised the ability of scientists to make genetically modified cells and animal models. Here, the authors make a Tet-On genetically modified mouse using the Streptococcus pyogenes Cas9 and demonstrate that it can be used
Anders Lundin, Michelle J. Porritt, Himjyot Jaiswal, Frank Seeliger, Camilla Johansson, Abdel Wahad Bidar, Lukas Badertscher, Sandra Wimberger, Emma J. Davies, Elizabeth Hardaker, Carla P. Martins, Emily James, Therese Admyre, Amir Taheri-Ghahfarokhi, Jenna Bradley, Anna Schantz, Babak Alaeimahabadi, Maryam Clausen, Xiufeng Xu, Lorenz M. Mayr, Roberto Nitsch, Mohammad Bohlooly-Y, Simon T. Barry, Marcello Maresca   +23 more
doaj   +1 more source

CRISPR/Cas9‐mediated genome editing: from basic research to translational medicine [PDF]

, 2020
The recent development of the CRISPR/Cas9 system as an efficient and accessible programmable genome-editing tool has revolutionized basic science research. CRISPR/Cas9 system-based technologies have armed researchers with new powerful tools to unveil the
Ferreira, B I, Jacinto, Filipe, Link, Wolfgang   +2 more
core   +1 more source

Genetically modified mice for research on human diseases: A triumph for Biotechnology or a work in progress?

The EuroBiotech Journal, 2022
Genetically modified mice are engineered as models for human diseases. These mouse models include inbred strains, mutants, gene knockouts, gene knockins, and ‘humanized’ mice.
Brown Richard E.
doaj   +1 more source

QPCTL regulates macrophage and monocyte abundance and inflammatory signatures in the tumor microenvironment

OncoImmunology, 2022
The enzyme glutaminyl-peptide cyclotransferase-like protein (QPCTL) catalyzes the formation of pyroglutamate residues at the NH2-terminus of proteins, thereby influencing their biological properties.
Kaspar Bresser, Meike E. W. Logtenberg, Mireille Toebes, Natalie Proost, Justin Sprengers, Bjorn Siteur, Manon Boeije, Lona J. Kroese, Ton N. Schumacher   +8 more
doaj   +1 more source

Functional genetic dropout screens and in vivo validation of candidate therapeutic targets using mouse mammary tumoroids

STAR Protocols, 2022
Summary: We have previously developed 3D tumoroids derived from genetically engineered mouse models (GEMMs) of BRCA1/2-deficient breast cancer. Here, we describe how to genetically modify tumoroids, use them for functional genetic dropout screens, and ...
Mariana Paes Dias, Sven Rottenberg, Jos Jonkers   +2 more
doaj   +1 more source

Molecular and cellular pathogenesis of adamantinomatous craniopharyngioma. [PDF]

, 2015
Adamantinomatous craniopharyngiomas (ACPs) are the most common pituitary tumours in children. Although histologically benign, these are clinically aggressive tumours, difficult to manage and associated with poor quality of life for the patients.
Martinez-Barbera, JP
core   +1 more source

A Simple and Fast Battery Test for Phenotypic Characterization of Mice

Bio-Protocol, 2020
Despite the great number of test batteries already known to assess the behavior of genetically modified and inbred strains of mice, only a few of them focus on basic neurological parameters.
Mariana Garcia-Gomes , Dennis Zanatto, Pedro Yamamoto, Danilo Wadt, Ana Antiorio, Jilma Aleman-Laporte, Sandra Alexandre-Ribeiro, Guilherme Marson, Cezar Guizzo, Silvia Massironi, Maria Bernardi, Claudia Mori   +11 more
doaj   +1 more source