Results 71 to 80 of about 439,037 (382)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

A Novel Quantification Method for Gene-Edited Animal Detection Based on ddPCR

Biology
As gene-editing technologies continue to evolve, gene-edited products are making significant strides. These products have already been commercialized in the United States and Japan, prompting global attention to their safety and regulatory oversight ...
Kaili Wang, Yi Ji, Cheng Peng, Xiaofu Wang, Lei Yang, Hangzhen Lan, Junfeng Xu, Xiaoyun Chen   +7 more
doaj   +1 more source

Attitudes toward genetically modified organisms in Poland: to GMO or not to GMO?

Food Security, 2016
Genetically modified organisms (GMOs) are a subject of on-going scientific, political and social discussions in Member States of the European Union (EU) concerning their use, benefits, risks, safety and limitations.
P. Rzymski, Aleksandra Królczyk
semanticscholar   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Development of a novel Cas13a/Cas12a-mediated 'one-pot' dual detection assay for genetically modified crops

Journal of Advanced Research
Introduction: Genetically modified (GM) crops have been widely cultivated across the world and the development of rapid, ultrasensitive, visual multiplex detection platforms that are suitable for field deployment is critical for GM organism regulation ...
Lin Ding, Xiaofu Wang, Xiaoyun Chen, Xiaoli Xu, Wei Wei, Lei Yang, Yi Ji, Jian Wu, Junfeng Xu, Cheng Peng   +9 more
doaj   +1 more source

Scientific Opinion on application (EFSA‐GMO‐NL‐2012‐108) for the placing on the market of the herbicide‐tolerant genetically modified soybean MON 87708 × MON 89788 for food and feed uses, import and processing under Regulation (EC) No 1829/2003 from Monsanto

EFSA Journal, 2015
Single events MON 87708 and MON 89788 were combined to produce the stack two‐event soybean MON 87708 × MON 89788. The EFSA GMO Panel previously assessed the two single events and did not identify safety concerns in the context of their scope. No new data
EFSA Panel on Genetically Modified Organisms (GMO)
doaj   +1 more source

Composting rapidly degrades DNA from genetically modified plants [PDF]

, 2004
Organic farmers are concerned about the use of genetically modified plants (GM plants) in conventional agriculture. The concern is mainly focused on the risk of spreading of pollen or seeds from GM plans to adjacent fields.
Magid, J., Møller, J., Rasmussen, L.D.
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Scientific Opinion on the application (EFSA‐GMO‐BE‐2012‐110) for the placing on the market of tissue‐selective herbicide‐tolerant genetically modified maize MON 87427 for food and feed uses, import and processing under Regulation (EC) No 1829/2003 from Monsanto

EFSA Journal, 2015
Maize MON 87427 was developed by Agrobacterium tumefaciens‐mediated transformation to express the CP4 5‐enolpyruvyl‐shikimate‐3‐phosphate synthase (EPSPS) protein, in all tissues except for the male reproductive tissues, conferring tissue‐selective ...
EFSA Panel on Genetically Modified Organisms (GMO)
doaj   +1 more source

Scientific Opinion on the annual post-market environmental monitoring (PMEM) report from Monsanto Europe S.A. on the cultivation of genetically modified maize MON 810 in 2012 [PDF]

EFSA Journal, 2014
Following a request from the European Commission, the Panel on Genetically Modified Organisms of the European Food Safety Authority (EFSA GMO Panel) assessed the post-market environmental monitoring (PMEM) report for the 2012 growing season of maize MON ...
EFSA Panel on Genetically Modified Organisms (GMO)
doaj   +1 more source