Results 41 to 50 of about 1,214,065 (255)

Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges

Proceedings of the National Academy of Sciences of the United States of America, 2017
Significance Identifying the drivers of the interindividual diversity of the human immune system is crucial to understand their consequences on immune-mediated diseases. By examining the transcriptional responses of 1,000 individuals to various microbial
B. Piasecka, D. Duffy, A. Urrutia, Hélène Quach, E. Patin, C. Posseme, Jacob Bergstedt, B. Charbit, V. Rouilly, C. MacPherson, M. Hasan, B. Albaud, D. Gentien, J. Fellay, M. Albert, L. Quintana-Murci   +15 more
semanticscholar   +1 more source

Considering Intra-individual Genetic Heterogeneity to Understand Biodiversity [PDF]

, 2019
In this chapter, I am concerned with the concept of Intra-individual Genetic Hetereogeneity (IGH) and its potential influence on biodiversity estimates. Definitions of biological individuality are often indirectly dependent on genetic sampling -and vice ...
A Cárdenas-Flores, A Roger, A Roger, AV Gonzalez, B Rinkevich, B Rinkevich, B Santelices, B Santelices, B Santelices, B Santelices, B Santelices, B Santelices, B Santelices, B Santelices, B Santelices, B Wang, C Angelard, C Wagg, DC Queller, DC Queller, DE Gill, DJ Herman, DS Wilson, E Boon, E Boon, E Boon, E Boon, E Clarke, G Kuhn, H Youssoufian, HJ Folse, HJ Folse, I Matos, I Zarraonaindia, IR Sanders, J Marleau, J Maynard Smith, J Vijg, JE Strassmann, JE Strassmann, JJ Morris, JO McInerney, JT Bonner, JT Staley, K Monro, L Collado-Vides, LW Buss, M Giovannetti, M Hijri, M O’Malley, M Pineda-Krch, M Pineda-Krch, M Schweinsberg, ME Samuels, MG Heijden van der, N Corradi, NB Spinner, P Bonfante, R Riley, RE Michod, RP Erickson, S Okasha, S Sarkar, S. Andrew Inkpen, T Fagerström, T Pradeu, T Wernberg, T Wyss, WF Doolittle, WF Doolittle   +69 more
core   +2 more sources

A Decade of Plague in Mahajanga, Madagascar: Insights into the Global Maritime Spread of Pandemic Plague

mBio, 2013
A cluster of human plague cases occurred in the seaport city of Mahajanga, Madagascar, from 1991 to 1999 following 62 years with no evidence of plague, which offered insights into plague pathogen dynamics in an urban environment.
Amy J. Vogler, Fabien Chan, Roxanne Nottingham, Genevieve Andersen, Kevin Drees, Stephen M. Beckstrom-Sternberg, David M. Wagner, Suzanne Chanteau, Paul Keim   +8 more
doaj   +1 more source

Enhancement of feather degrading keratinase of Streptomyces swerraensis KN23, applying mutagenesis and statistical optimization to improve keratinase activity

BMC Microbiology, 2023
In this study, 25 actinomyces isolates were obtained from 10 different poultry farms and tested for their keratinase activity. The isolate with the highest keratinase activity was identified through molecular identification by PCR and sequencing of the ...
Nagwa M. Abd El-Aziz, Bigad E. Khalil, Hayam Fouad Ibrahim   +2 more
doaj   +1 more source

Comparison of Channel Catfish and Blue Catfish Gut Microbiota Assemblages Shows Minimal Effects of Host Genetics on Microbial Structure and Inferred Function

Frontiers in Microbiology, 2018
The microbiota of teleost fish has gained a great deal of research attention within the past decade, with experiments suggesting that both host-genetics and environment are strong ecological forces shaping the bacterial assemblages of fish microbiomes ...
Jacob W. Bledsoe, G. Waldbieser, K. Swanson, B. Peterson, B. Small   +4 more
semanticscholar   +1 more source

Ifnar gene variants influence gut microbial production of palmitoleic acid and host immune responses to tuberculosis

Nature Metabolism, 2022
Both host genetics and the gut microbiome have important effects on human health, yet how host genetics regulates gut bacteria and further determines disease susceptibility remains unclear.
Lingming Chen, Guoliang Zhang, Guobao Li, Wei Wang, Zhenhuang Ge, Yi Yang, Xing He, Zhi Liu, Zhiyi Zhang, Q. Mai, Yiwei Chen, Zi-mo Chen, Jiang Pi, Shuai Yang, J. Cui, Haipeng Liu, Ling Shen, Lingchan Zeng, Lin Zhou, Xinchun Chen, Baoxue Ge, Zheng W. Chen, G. Zeng   +22 more
semanticscholar   +1 more source

cual-id: Globally Unique, Correctable, and Human-Friendly Sample Identifiers for Comparative Omics Studies

mSystems, 2016
The number of samples in high-throughput comparative “omics” studies is increasing rapidly due to declining experimental costs. To keep sample data and metadata manageable and to ensure the integrity of scientific results as the scale of these projects ...
John H. Chase, Evan Bolyen, Jai Ram Rideout, J. Gregory Caporaso   +3 more
doaj   +1 more source

Advancing Drug Resistance Research Through Quantitative Modeling and Synthetic Biology [PDF]

Frontiers in Bioengineering and Biotechnology, 8: 583415 (2020), 2020
Antimicrobial resistance is an emerging global health crisis that is undermining advances in modern medicine and, if unmitigated, threatens to kill 10 million people per year worldwide by 2050. Research over the last decade has demonstrated that the differences between genetically identical cells in the same environment can lead to drug resistance ...
arxiv   +1 more source

Host genetics, phenotype and geography structure the microbiome of a foundational seaweed

Molecular Ecology, 2022
Interactions between hosts and their microbiota are vital to the functioning and resilience of macro‐organisms. Critically, for hosts that play foundational roles in communities, understanding what drives host–microbiota interactions is essential for ...
Georgina Wood, P. Steinberg, A. Campbell, A. Vergés, M. Coleman, E. Marzinelli   +5 more
semanticscholar   +1 more source

Adaptive tuning of mutation rates allows fast response to lethal stress in Escherichia coli

eLife, 2017
While specific mutations allow organisms to adapt to stressful environments, most changes in an organism's DNA negatively impact fitness. The mutation rate is therefore strictly regulated and often considered a slowly-evolving parameter.
Toon Swings, Bram Van den Bergh, Sander Wuyts, Eline Oeyen, Karin Voordeckers, Kevin J Verstrepen, Maarten Fauvart, Natalie Verstraeten, Jan Michiels   +8 more
doaj   +1 more source