Results 61 to 70 of about 6,725,001 (330)
Non-stationary patterns of isolation-by-distance: inferring measures of local genetic differentiation with Bayesian kriging [PDF]
, 2012 Patterns of isolation-by-distance arise when population differentiation increases with increasing geographic distances. Patterns of isolation-by-distance are usually caused by local spatial dispersal, which explains why differences of allele frequencies between populations accumulate with distance.
arxiv +1 more source
Genetic evolution of a multi-generational population in the context of interstellar space travels -- Part I: Genetic evolution under the neutral selection hypothesis [PDF]
arXiv, 2021 We updated the agent based Monte Carlo code HERITAGE that simulates human evolution within restrictive environments such as interstellar, sub-light speed spacecraft in order to include the effects of population genetics. We incorporated a simplified -- yet representative -- model of the whole human genome with 46 chromosomes (23 pairs), containing 2110
arxiv
Efficient pedigree recording for fast population genetics simulation
bioRxiv, 2018 In this paper we describe how to efficiently record the entire genetic history of a population in forwards-time, individual-based population genetics simulations with arbitrary breeding models, population structure and demography.
Jerome Kelleher +3 more
semanticscholar +1 more source
Demographic history and genomics of local adaptation in blue tit populations
Evolutionary Applications, 2020 Understanding the genomic processes underlying local adaptation is a central aim of modern evolutionary biology. This task requires identifying footprints of local selection but also estimating spatio‐temporal variations in population demography and ...
Charles Perrier +2 more
doaj +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
The population genetics of evolutionary rescue. [PDF]
PLoS Genetics, 2014 Evolutionary rescue occurs when a population that is threatened with extinction by an environmental change adapts to the change sufficiently rapidly to survive. Here we extend the mathematical theory of evolutionary rescue.
H Allen Orr, Robert L Unckless
doaj +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
A review of population genetics and the prospects for crop improvement
Academia Biology, 2023 This study discusses the importance of population genetics in the context of crop improvement and its role in addressing challenges related to food security.
Godswill Ntsomboh-Ntsefong +9 more
doaj +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Genetic diversity in introduced populations with Allee effect [PDF]
arXiv, 2013 A phenomenon that strongly influences the demography of small introduced populations and thereby potentially their genetic diversity is the Allee effect, a reduction in population growth rates at small population sizes. We take a stochastic modeling approach to investigate levels of genetic diversity in populations that successfully overcame a strong ...
arxiv