Results 61 to 70 of about 7,457,933 (340)
Scientific ReportsInbreeding depression, the loss of offspring fitness due to consanguineous mating, is generally detrimental for individual performance and population viability.
A. J. Paijmans +6 more
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Population genetics and GWAS: A primer. [PDF]
PLoS Biology, 2018 This primer provides some background to help non-specialists understand a new theoretical evolutionary genetics study that helps explain why thousands of variants of small effect contribute to complex traits.
Greg Gibson
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FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Population-Matched Transcriptome Prediction Increases TWAS Discovery and Replication Rate
iScience, 2020 Summary: Most genome-wide association studies (GWAS) and transcriptome-wide association studies (TWAS) focus on European populations; however, these results cannot always be accurately applied to non-European populations due to genetic architecture ...
Elyse Geoffroy +2 more
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Dualities in population genetics: a fresh look with new dualities [PDF]
, 2014 We apply our general method of duality, introduced in [Giardina', Kurchan, Redig, J. Math. Phys. 48, 033301 (2007)], to models of population dynamics.
Carinci, Gioia +3 more
core +2 more sources
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
The evolutionary history of LysM-RLKs (LYKs/LYRs) in wild tomatoes
BMC Evolutionary Biology, 2019 Background The LysM receptor-like kinases (LysM-RLKs) are important to both plant defense and symbiosis. Previous studies described three clades of LysM-RLKs: LysM-I/LYKs (10+ exons per gene and containing conserved kinase residues), LysM-II/LYRs (1–5 ...
Sarah Richards, Laura E. Rose
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The evolution of moment generating functions for the Wright Fisher model of population genetics
, 2014 We derive and apply a partial differential equation for the moment generating function of the Wright-Fisher model of population ...
Hofrichter, Julian +2 more
core +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
In silico characterization of coding and non-coding SNPs of the androgen receptor gene
Informatics in Medicine Unlocked, 2021 The Androgen Receptor (AR), an important ligand-dependent nuclear transcription factor, encoded by the AR gene, functions in regulating the cell proliferation, migration, invasion, and apoptosis pathways. Single nucleotide polymorphisms (SNPs) of AR have
Maisha Adiba +6 more
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