Results 81 to 90 of about 243,769 (354)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
MALE STERILITY 3 encodes a plant homeodomain‐finger protein for male fertility in soybean
Journal of Integrative Plant Biology, 2022 Male‐sterile plants are used in hybrid breeding to improve yield in soybean (Glycine max (L.) Merr.). Developing the capability to alter fertility under different environmental conditions could broaden germplasm resources and simplify hybrid production ...
Jingjing Hou +13 more
semanticscholar +1 more source
Cells, 2022 Male sterility represents an important trait for hybrid breeding and seed production in crops. Although the genes required for male fertility have been widely studied and characterized in many plant species, most of them are single genic male-sterility ...
Xinze Liu +9 more
doaj +1 more source
Synthetic Biology, 2019 In this chapter, we summarize the strategies about molecular cloning and functional confirmation of plant genic male-sterility (GMS) genes and their applications for hybrid breeding and seed production via biotechnology-based male-sterility (BMS) systems
Xiangyuan Wan, Suowei Wu
semanticscholar +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Genetic characterisation of a novel male sterile two-type line system 19F08AB in Brassica napus L.
Czech Journal of Genetics and Plant BreedingRapeseed (Brassica napus L.) is a major global oilseed crop and exhibits significant heterosis. The discovery and characterisation of novel male-sterile accessions remain fundamental for harnessing heterosis in rapeseed breeding. Previously, we developed
Lirong Zhao +7 more
doaj +1 more source
Field evaluation of thermosensitive genic male sterile lines
, 1998 This article 'Field evaluation of thermosensitive genic male sterile lines' appeared in the International Rice Research Notes series, created by the International Rice Research Institute (IRRI) to expedite communication among scientists concerned with the development of improved technology for rice and rice-based systems.
Vijakumar, C. H. M. +4 more
openaire +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Recent progress on molecular breeding of rice in China [PDF]
, 2014 Molecular breeding of rice for high yield, superior grain quality, and strong environmental adaptability is crucial for feeding the world’s rapidly growing population.
Qian Qian, Yuanyuan Li, Yuchun Rao
core +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source