Results 191 to 200 of about 29,159 (222)
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Phytochemistry, 2002
Genistein (4',5,7-trihydroxyisoflavone) is a common precursor in the biosynthesis of antimicrobial phytoalexins and phytoanticipins in legumes, and an important nutraceutical molecule found in soybean seeds. Genistein is a phytoestrogen with a wide variety of pharmacological effects in animal cells, including tyrosine kinase inhibition, and dietary ...
Richard A. Dixon, Daneel Ferreira
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Genistein (4',5,7-trihydroxyisoflavone) is a common precursor in the biosynthesis of antimicrobial phytoalexins and phytoanticipins in legumes, and an important nutraceutical molecule found in soybean seeds. Genistein is a phytoestrogen with a wide variety of pharmacological effects in animal cells, including tyrosine kinase inhibition, and dietary ...
Richard A. Dixon, Daneel Ferreira
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Genistein and hematological malignancies
Cancer Letters, 2010Genistein is an isoflavanoid from soybeans and promising cancer chemotherapeutic agent. Genistein exposure varies widely because of cultural differences in diet. Hypothetically, this could account for differential cancer risk across ethnic populations.
Lynn T. Frame +3 more
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Pharmacological postconditioning with the phytoestrogen genistein
Journal of Molecular and Cellular Cardiology, 2007Estrogens are known to activate the phosphatidyl-inosityl 3-kinase (PI3K)/Akt pathway, which is central in the cardioprotection afforded by ischemic postconditioning. Therefore, our goal was to investigate whether a phytoestrogen, genistein, could induce a pharmacological postconditioning and to investigate potential mechanisms.
N. Couvreur +17 more
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Cardiovascular Effects of the Phytoestrogen Genistein
Current Medicinal Chemistry-Cardiovascular & Hematological Agents, 2004Phytoestrogenic molecules have received a great deal of attention over the last few years because of their potentially preventive roles against a few of today's most prevalent chronic diseases, namely cardiovascular diseases, osteoporosis and hormone related cancers.
ALTAVILLA, Domenica +7 more
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Genetic toxicity studies with genistein
Food and Chemical Toxicology, 2006Genistein is a phytoestrogen that occurs naturally in the diet especially in soybeans and soy-based foods. Genistein and related phytoestrogens are of interest as chemopreventive agents for a variety of diseases and cancers based on epidemiologic evidence of reduced cancer rates in populations with a high intake of soy.
Jochen Bausch +3 more
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Reactions of Genistein with Alkylperoxyl Radicals
Chemical Research in Toxicology, 2000Antioxidant actions of the soy isoflavone genistein are believed to contribute to its overall chemopreventive activity. However, the mechanisms of its antioxidant reactions remain unknown. The objective of this study was to characterize the reaction products of genistein (5,7,4'-trihydroxyisoflavone) with peroxyl radicals generated by thermolysis of 2 ...
Barbara N. Timmermann +5 more
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Genistein in the Treatment of Hypertension: A Review
Endocrine, Metabolic & Immune Disorders - Drug Targets, 2022Abstract:Genistein, a natural compound belonging to the group of isoflavones has a confirmed positive effect in such diseases as hormone-dependent cancers, osteoporosis, and cardiovascular diseases, including arterial and pulmonary hypertension. The multiway hypotensive effect is based on vasodilation with simultaneous inhibition of vasoconstriction ...
Paulina Sigowska +5 more
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Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2005
Soy-derived isoflavone phytoestrogens, such as genistein (4',5,7-trihydroxyisoflavone), have been shown to protect low-density lipoprotein from oxidation. In addition, human plasma was previously shown to be capable of converting genistein into lipophilic fatty acid esters that accumulate in lipoproteins in vitro.
Kristiina Wähälä +7 more
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Soy-derived isoflavone phytoestrogens, such as genistein (4',5,7-trihydroxyisoflavone), have been shown to protect low-density lipoprotein from oxidation. In addition, human plasma was previously shown to be capable of converting genistein into lipophilic fatty acid esters that accumulate in lipoproteins in vitro.
Kristiina Wähälä +7 more
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The conversion of genistein to equol in the fowl
Biochimica et Biophysica Acta (BBA) - General Subjects, 1964Abstract The possibility that equol in the urine of the domestic fowl may represent a conversion product of genistein has been investigated. Genistein was randomly tritiated by the Wilzbach process and purified by repeated crystallization and paper chromatography. The purified material was injected intramuscularly into a non-laying hen. The urine for
A L Carter, R.H. Common, M.N. Cayen
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Direct action of genistein on CFTR
Pfl�gers Archiv European Journal of Physiology, 1997Human cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels were expressed in oocytes from Xenopus laevis after injection of CFTR cRNA and studied with the two-electrode voltage-clamp and the giant patch techniques. The tyrosine kinase inhibitor genistein alone activated a small chloride current in whole oocytes expressing CFTR ...
Phillip G. Wood +3 more
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