Results 61 to 70 of about 31,152 (194)

Mitophagy and Bip–PERK–eIF2α–ATF4 Axis‐Mediated ER Stress Mediate Miriplatin‐Loaded Liposome's Anti‐Colorectal Cancer Action

Cell Proliferation, EarlyView.
LMPt enters the cell mainly through caveolin‐mediated endocytosis, and then fuses with endosomes and lysosomes to deliver MPt to mitochondria and the endoplasmic reticulum to induce mitophagy based on the fusion of lysosomes and mitochondria, and endoplasmic reticulum stress and subsequent apoptosis via the Bip–PERK–eIF2α–ATF4 axis to exert an anti ...
Cong Zhao, Yuhan Qiu, Xiaowei Wang, Mengyan Wang, Li Liu, Xiaojun Zhao, Zixiang Gao, Rongguang Shao, Guimin Xia, Wuli Zhao   +9 more
wiley   +1 more source

The dysregulation of innate immunity by Porphyromonas gingivalis in the etiology of Alzheimer's disease

Journal of Internal Medicine, EarlyView.
Abstract The etiology of Alzheimer's disease (AD) remains under active debate. In this perspective, we explore the hypothesis that a primarily infection‐caused chronic dysregulation and weakening of human innate immunity via the underexpression, degradation, and inactivation of innate immune proteins necessary for direct antimicrobial effects and ...
Annelise E. Barron, Jennifer S. Lin, Mark I. Ryder, Peter Bergman   +3 more
wiley   +1 more source

Genistein Inhibits Rat Aortic Smooth Muscle Cell Proliferation Through the Induction of p27kip1

Journal of Pharmacological Sciences, 2008
Diet is one of the most important factors that influence the risks for cardiovascular diseases. Genistein, an isoflavone found in soy, may benefit the cardiovascular system. Here, we investigated the effect of genistein on platelet-derived growth factor (
Ji-Yeon Yu, Jung-Jin Lee, Yong Lim, Tack-Joong Kim, Yong-Ri Jin, Yhun Y. Sheen, Yeo-Pyo Yun   +6 more
doaj   +1 more source

Steroid Hormones Are Potent and Putatively Endogenous Activators of Human Bitter Taste Receptors

Annals of the New York Academy of Sciences, EarlyView.
Human bitter taste receptors are not only involved in sensing tastants within the oral cavity but also play crucial roles in internal tissues of the body. The current report identifies numerous structurally and functionally diverse steroid hormones as activators of the two human bitter taste receptors, TAS2R14 and TAS2R46.
Tatjana Lang, Francesco Ferri, Florian Ziegler, Antonella Di Pizio, Maik Behrens   +4 more
wiley   +1 more source

GmMYB4 Positively Regulates Isoflavone Biosynthesis via the GmMAPK6‐GmMYB4‐MBW Module in Soybean

Plant Biotechnology Journal, EarlyView.
ABSTRACT Isoflavones, a class of bioactive compounds predominantly found in leguminous plants, are largely responsible for their beneficial effects on human health. Although MYB transcription factors (TFs) are known to be crucial regulators of isoflavone biosynthesis in soybean, the precise mechanisms underlying their regulatory functions remain poorly
Changyun Yang, Peipei Zhang, Pingbo Jiang, Yingying Song, Junyu Wang, Wenyan Hou, Zhongyi Yang, Wei Zhao, Yixiang Pu, Shanshan Chu, Jiao Wang, Hao Cheng, Deyue Yu   +12 more
wiley   +1 more source

Genistein Promotes Skeletal Muscle Regeneration by Regulating miR-221/222 [PDF]

, 2022
Linyuan Shen, Tianci Liao, Jingyun Chen, Jianfeng Ma, Jinyong Wang, Lei Chen, Shunhua Zhang, Zhao Ye, Lili Niu, Changjun Zeng, Mailin Gan, Li Zhu   +11 more
openalex   +1 more source

Engineering of the Flavone Rutinoside Biosynthetic Pathway Enables Production of Diosmin, a Venoactive Compound in Solanum lycopersicum and Nicotiana tabacum

Plant Biotechnology Journal, EarlyView.
ABSTRACT Diosmin is often used as a dietary supplement, and it is sometimes used to make phlebotropic drugs for venous diseases. Traditionally, diosmin is obtained by the dehydrogenation of the flavanone glycoside hesperidin through chemical semisynthesis.
Qianle Zhang, Qingwen Wu, Wenjing Shi, Yinai Deng, Ruoting Zhan, Dongming Ma   +5 more
wiley   +1 more source

Dietary intake of genistein suppresses hepatocellular carcinoma through AMPK-mediated apoptosis and anti-inflammation

BMC Cancer, 2019
Background Women have a lower risk of hepatocellular carcinoma (HCC) than men, and the decreased possibility of HCC in women is thought to depend on estrogen levels.
Sang R. Lee, Sun Woo Kwon, Young Ho Lee, Pelin Kaya, Jong Min Kim, Changhwan Ahn, Eui-Man Jung, Geun-Shik Lee, Beum-Soo An, Eui-Bae Jeung, Bae-keun Park, Eui-Ju Hong   +11 more
doaj   +1 more source

Reprogramming of Gene Transcripts and Metabolites by the Wild Soybean Endophyte Pseudomonas sp. 77S3 Improves Soybean Salt Tolerance

Plant Biotechnology Journal, EarlyView.
ABSTRACT Soybean is a critical source of protein and vegetable oil worldwide. Expanding its cultivation into salinity lands represents a promising strategy for increasing production; however, soil salinity severely limits soybean growth by disrupting physiological and metabolic homeostasis.
Wanying Zhang, Chengyang Song, Tianqi Wang, Xiulin Liu, Yisheng Fang, Zhu Yan, Yaxi Zhu, Na Zheng, Xiaofei Ma, Guochen Qin, Dan Zhu, Junchuan Xiao, Xing Wang Deng, Xiao Luo   +13 more
wiley   +1 more source

Effect of Genistein on Starch Digestion In Vitro and Its Mechanism of Action

Foods
The digestive properties of starch are crucial in determining postprandial glycaemic excursions. Genistein, an active phytoestrogen, has the potential to influence starch digestion rates.
Jianhui Jia, Boxin Dou, Man Gao, Chujia Zhang, Ying Liu, Na Zhang   +5 more
doaj   +1 more source