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FEMS Microbiology Reviews, 1994 During the last decade, great advances have been made in the study of bacterial genomes which is perhaps better described by the term bacterial genomics. The application of powerful techniques, such as pulsed-field gel electrophoresis of macro-restriction fragments of genomic DNA, has freed the characterisation of the chromosomes of many bacteria from ...
S T, Cole, I, Saint Girons
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Bacterial Genome Instability [PDF]
Microbiology and Molecular Biology Reviews, 2014 SUMMARY Bacterial genomes are remarkably stable from one generation to the next but are plastic on an evolutionary time scale, substantially shaped by horizontal gene transfer, genome rearrangement, and the activities of mobile DNA elements. This implies the existence of a delicate balance between the maintenance of genome stability and the ...
Elise, Darmon, David R F, Leach
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Bacterial genome mapper: A comparative bacterial genome mapping tool [PDF]
Bioinformation, 2012 Recently, next generation sequencing (NGS) technologies have led to a revolutionary increase in sequencing speed and costefficacy. Consequently, a vast number of contigs from many recently sequenced bacterial genomes remain to be accurately mapped and annotated, requiring the development of more convenient bioinformatics programs.
Lee, Kang Seon +12 more
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Bacterial Genomics and Epidemiology
Microorganisms, 2023 Innovative technologies for Whole-Genome Sequencing (WGS) help to improve our understanding of the epidemiology and pathogenesis of bacterial infectious diseases and are becoming affordable for most microbiological laboratories [...]
Javier Garaizar, Lorena Laorden
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Bacterial Genomes: Habitat Specificity and Uncharted Organisms [PDF]
Microbial Ecology, 2012 The capability and speed in generating genomic data have increased profoundly since the release of the draft human genome in 2000. Additionally, sequencing costs have continued to plummet as the next generation of highly efficient sequencing technologies (next-generation sequencing) became available and commercial facilities promote market competition.
Dini-Andreote, Francisco +4 more
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Genomics and Bacterial Pathogenesis [PDF]
Emerging Infectious Diseases, 2000 Whole-genome sequencing is transforming the study of pathogenic bacteria. Searches for single virulence genes can now be performed on a genomewide scale by a variety of computer and genetic techniques. These techniques are discussed to provide a perspective on the developing field of genomics.
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Genomics and Bacterial Metabolism [PDF]
Current Issues in Molecular Biology, 2003 The field of bacterial metabolism and physiology is arguably the oldest in microbiology. Much of our understanding of biological processes and molecular paradigms has its roots In early studies of prokaryotic physiology. After a period of declining interest in metabolic studies (prompted by the insurgence of molecular techniques), genomic technologies ...
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Dynamic bacterial genome organization [PDF]
Molecular Microbiology, 1997 Recently completed projects of sequencing chromosomal fragments and entire chromosomes, as well as physical mapping of genomes, have opened novel inroads to the understanding of the biology of bacterial genomes. From these studies one may draw some conclusions.
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Bacterial evolution: Jittery genomes [PDF]
Current Biology, 1999 Recent studies of long-term experimental populations of bacteria have revealed the actual progression of evolutionary change and how rates of phenotypic evolution can be decoupled from rates of genomic evolution.
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Genomic Arrangement of Regulons in Bacterial Genomes
PLoS ONE, 2012 Regulons, as groups of transcriptionally co-regulated operons, are the basic units of cellular response systems in bacterial cells. While the concept has been long and widely used in bacterial studies since it was first proposed in 1964, very little is known about how its component operons are arranged in a bacterial genome.
Han Zhang +3 more
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