Results 21 to 30 of about 99 (98)

Pan‐cancer analysis shapes the understanding of cancer biology and medicine

Cancer Communications, EarlyView.
Abstract Advances in multi‐omics datasets and analytical methods have revolutionized cancer research, offering a comprehensive, pan‐cancer perspective. Pan‐cancer studies identify shared mechanisms and unique traits across different cancer types, which are reshaping diagnostic and treatment strategies.
Xiaoping Cen, Yuanyuan Lan, Jiansheng Zou, Ruilin Chen, Can Hu, Yahan Tong, Chen Zhang, Jingyue Chen, Yuanmei Wang, Run Zhou, Weiwei He, Tianyu Lu, Fred Dubee, Dragomirka Jovic, Wei Dong, Qingqing Gao, Man Ma, Youyong Lu, Yu Xue, Xiangdong Cheng, Yixue Li, Huanming Yang   +21 more
wiley   +1 more source

Promising Prodiginins Biological Activities

Chemistry &Biodiversity, EarlyView.
ABSTRACT Prodiginins are a large family of at least 34 pyrrolic compounds, including the well‐studied red pigment prodigiosin. Prodiginins are produced by several microorganisms displaying broad biological activities, including antimicrobial, antiviral, antiparasitic, antiproliferative, and immunosuppressive activities.
María F. Ladetto, Melisa E. Gantner, Boris E. Rodenak‐Kladniew, Santiago Rodriguez, María L. Cuestas, Alan Talevi, Guillermo R. Castro   +6 more
wiley   +1 more source

Characterization of the Cubamyces Menziesii Terpenome

ChemBioChem, EarlyView.
The genome of Cubamyces menziesii reveals 18 putative sesquiterpene cyclase genes. These genes are cloned and expressed in Escherichia coli, yielding 10 active enzymes. Using farnesyl diphosphate as substrate, the enzymes are analyzed, and the products characterized after bioconversion, uncovering diverse sesquiterpene structures. This study highlights
Létitia Leydet, Julie Couillaud, Agnès Amouric, Elise Courvoisier‐Dezord, Carole Avesque, Thierry Giardina, Mireille Attolini, Pierre Rousselot‐Pailley, Katia Duquesne, Marie‐Noelle Rosso, Gilles Iacazio   +10 more
wiley   +1 more source

Prevalence of Cystic Fibrosis Carrier Status in Chronic Rhinosinusitis Without Nasal Polyp

International Forum of Allergy &Rhinology, EarlyView.
Do‐Yeon Cho, Adam J. Skelton, Jessica W. Grayson, Justin H. Turner, Bradford A. Woodworth   +4 more
wiley   +1 more source

Mining Thermophile Genomes for New PETases with Exceptional Thermostabilities Using Sequence Similarity Networks

ChemBioChem, EarlyView.
Targeted genome mining identified thermostable enzymes (PETases) that hydrolyze the commonly used plastic polymer polyethylene terephthalate (PET). Thermostable enzymes are identified from thermophilic microbial sources. Experimental results reveal enzymatic activity on authentic PET films, highlighting potential for industrial application.
Zhenyu Hu, Kody Klupt, David L. Zechel, Zongchao Jia, Graeme Howe   +4 more
wiley   +1 more source

Clade III Synthases Add Cyclic And Linear Terpenoids To The Psilocybe Metabolome

ChemBioChem, Accepted Article.
Psilocybe “magic mushrooms” are best known for their indolethylamine psilocybin, yet they encode enzymes for a much more diverse arsenal of small and potentially bioactive molecules. Here, we report on four Psilocybe cubensis clade III sesquiterpene synthases, CubB‐CubE, whose genes are differently expressed in fruiting bodies compared to vegetative ...
Nick Zschoche, Sebastian Schober, Karl Walther, Andrew R. Chadeayne, Markus Gressler, Stefan Bartram, Sarah E. O'Connor, Dirk Hoffmeister   +7 more
wiley   +1 more source

Biosynthesis of the Fungal Cyclic Lipodepsipeptide Pleosporacin, a New Selective Inhibitor of the Phytopathogen Botrytis cinerea

ChemBioChem, EarlyView.
Bioactivity‐guided isolation led to the discovery of a potent and selective inhibitor of the phytopathogen Botrytis cinerea, pleosporacin (1), from mycelia extracts of the fungal strain Pleosporales sp. IBWF 020‐21. The biosynthesis of the nonribosomal cyclic lipodepsipeptide 1 was elucidated via heterologous reconstitution in Aspergillus oryzae ...
Carsten Wieder, Rainer Wiechert, Alexander Yemelin, Louis Pergaud Sandjo, Eckhard Thines, Till Opatz, Anja Schüffler   +6 more
wiley   +1 more source

Controlling Lampenflora in Heritage Sites: In Situ Testing of Polyoxometalate–Ionic Liquids in the Pommery Champagne Cellar

ChemPlusChem, EarlyView.
The article evaluates polyoxometalate–ionic liquids (POM–ILs) as biocidal agents against lampenflora in the UNESCO‐listed Pommery Champagne cellar. POM–ILs effectively inhibit microbial colonization over one year with minimal visual impact and outperform the commercial biocide Preventol RI80.
Stéphanie Eyssautier‐Chuine, Ludovic Besaury, Nathalie Vaillant‐Gaveau, Sandra Villaume, Anouck Habrant, Isabel Franco‐Castillo, Marine Rondeau, Dina Aggad, Maxime Gommeaux, Gilles Fronteau, Scott G. Mitchell   +10 more
wiley   +1 more source

Self‐Emulsifying Biocatalysis Based on an Amphipathic Protein BslA‐Modified Esterase Functioning as a Fine‐Tuned System for Oil Hydrolysis

Food Bioengineering, EarlyView.
BslA is a promising tool to create an robust self‐emulsifying biocatalysis platform by reducing the droplet sizes of emulsion and improving its stability. It could guarantee the efficient hydrolysis of astaxanthin esters catalyzed by Est3‐14 without extra emusifier, increasing the yield of free astaxanthin to 184 μg·mL−1.
Xiaoxuan Yao, Kunpeng Gao, Hao Dong, Qian Sun, Jingyuan Liu, Yang Hu, Jianan Sun, Xiangzhao Mao   +7 more
wiley   +1 more source

An investigation into the transcription factors and regulatory mechanisms of Aspergillus

Food Safety and Health, EarlyView.
Foodborne pathogen Aspergillus, a prevalent etiologic agent among filamentous fungi, are distinguished by a significant repertoire of transcription factors encoded within their genomes. These regulatory proteins are instrumental in orchestrating key biological processes, including cellular growth, secondary metabolite biosynthesis, mycotoxin production,
Yuxin Qin, Huawei Yu, Jun Tian
wiley   +1 more source